Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects
Abstract Aim The present study was conducted with the objective ascertaining the clinical implication of microRNA-133a-3p (miR-133a-3p) for urinary incontinence (UI) and rehabilitation effects in prostate cancer after radical prostatectomy. Methods The measurements of miR-133a-3p in urethral tissue...
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BMC
2025-05-01
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| Series: | Hereditas |
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| Online Access: | https://doi.org/10.1186/s41065-025-00443-2 |
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| author | Fan Yang Qiuxia Qin Juan Liu |
| author_facet | Fan Yang Qiuxia Qin Juan Liu |
| author_sort | Fan Yang |
| collection | DOAJ |
| description | Abstract Aim The present study was conducted with the objective ascertaining the clinical implication of microRNA-133a-3p (miR-133a-3p) for urinary incontinence (UI) and rehabilitation effects in prostate cancer after radical prostatectomy. Methods The measurements of miR-133a-3p in urethral tissue samples from prostate cancer patients after radical prostatectomy were carried out via quantitative real-time polymerase chain reaction (qRT-PCR) detection. Receiver operation characteristic (ROC) curve and logistic regression analysis were employed for evaluating the predictive significance of miR-133a-3p for the early UI of prostate cancer patients with radical prostatectomy. Bioinformatics tools were employed for mining the miR-133a-3p possible genes. Results An obvious reduction of miR-133a-3p was detected in patients with UI compared with those with urinary continence (UC) (P < 0.001), demonstrating a high diagnostic capacity for patients with UI. Moreover, miR-133a-3p could be an independent predictive index for the early UI in patients with prostate cancer after radical prostatectomy (P < 0.001). Additionally, urine miR-133a-3p was notably increased in the UI patients after rehabilitation (P < 0.001). MiR-133a-3p largely concentered on the muscle-related diseases pathways using bioinformatics tools. Conclusion MiR-133a-3p was a promising indicator for predicting early UI in patients with prostate cancer after radical prostatectomy. Clinical trial number Not applicable. |
| format | Article |
| id | doaj-art-d7dccf8101bf40859010d0dfe1f85734 |
| institution | Kabale University |
| issn | 1601-5223 |
| language | English |
| publishDate | 2025-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Hereditas |
| spelling | doaj-art-d7dccf8101bf40859010d0dfe1f857342025-08-20T03:48:06ZengBMCHereditas1601-52232025-05-01162111110.1186/s41065-025-00443-2Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effectsFan Yang0Qiuxia Qin1Juan Liu2Nursing Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyNursing Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyNursing Department, Tongji Hospital, Tongji Medical College, Huazhong University of Science and TechnologyAbstract Aim The present study was conducted with the objective ascertaining the clinical implication of microRNA-133a-3p (miR-133a-3p) for urinary incontinence (UI) and rehabilitation effects in prostate cancer after radical prostatectomy. Methods The measurements of miR-133a-3p in urethral tissue samples from prostate cancer patients after radical prostatectomy were carried out via quantitative real-time polymerase chain reaction (qRT-PCR) detection. Receiver operation characteristic (ROC) curve and logistic regression analysis were employed for evaluating the predictive significance of miR-133a-3p for the early UI of prostate cancer patients with radical prostatectomy. Bioinformatics tools were employed for mining the miR-133a-3p possible genes. Results An obvious reduction of miR-133a-3p was detected in patients with UI compared with those with urinary continence (UC) (P < 0.001), demonstrating a high diagnostic capacity for patients with UI. Moreover, miR-133a-3p could be an independent predictive index for the early UI in patients with prostate cancer after radical prostatectomy (P < 0.001). Additionally, urine miR-133a-3p was notably increased in the UI patients after rehabilitation (P < 0.001). MiR-133a-3p largely concentered on the muscle-related diseases pathways using bioinformatics tools. Conclusion MiR-133a-3p was a promising indicator for predicting early UI in patients with prostate cancer after radical prostatectomy. Clinical trial number Not applicable.https://doi.org/10.1186/s41065-025-00443-2MiR-133a-3pUrinary incontinenceRehabilitationPredictive value |
| spellingShingle | Fan Yang Qiuxia Qin Juan Liu Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects Hereditas MiR-133a-3p Urinary incontinence Rehabilitation Predictive value |
| title | Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects |
| title_full | Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects |
| title_fullStr | Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects |
| title_full_unstemmed | Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects |
| title_short | Predictive value of microRNA-133a-3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects |
| title_sort | predictive value of microrna 133a 3p for early urinary incontinence after radical prostatectomy for prostate cancer and its correlation with rehabilitation effects |
| topic | MiR-133a-3p Urinary incontinence Rehabilitation Predictive value |
| url | https://doi.org/10.1186/s41065-025-00443-2 |
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