Natural Killer (NK) Cell Alloreactivity in Haploidentical Stem Cell Transplantation
This paper conducts a literature review on the role of natural killer cells in haploidentical hematopoietic stem cell transplantation. Theoretical concepts related to <i>KIR</i> genes are introduced regarding their structure, nomenclature, genetic organization, polymorphism, and inherita...
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| Format: | Article |
| Language: | English |
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MDPI AG
2025-07-01
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| Series: | Cells |
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| Online Access: | https://www.mdpi.com/2073-4409/14/14/1091 |
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| author | Mar Luis-Hidalgo José Luis Piñana Carlos Solano Dolores Planelles |
| author_facet | Mar Luis-Hidalgo José Luis Piñana Carlos Solano Dolores Planelles |
| author_sort | Mar Luis-Hidalgo |
| collection | DOAJ |
| description | This paper conducts a literature review on the role of natural killer cells in haploidentical hematopoietic stem cell transplantation. Theoretical concepts related to <i>KIR</i> genes are introduced regarding their structure, nomenclature, genetic organization, polymorphism, and inheritance pattern, types of KIR proteins and receptors, HLA ligands for KIR receptors, and the definition of different NK alloreactivity prediction models for the donor of haploidentical hematopoietic stem cell transplantation and the recipient. These models include the following and consider incompatibility: ligand–ligand, receptor–ligand, gene–gene, and KIR haplotype models or the <i>KIR-B</i> donor group. These models consider the presence or absence of specific ligands or receptors and/or <i>KIR</i> genes in the donor and recipient to predict alloreactivity. Determining the best model for predicting KIR alloreactivity and its significance in donor selection algorithms for haploidentical transplantation is still under investigation. |
| format | Article |
| id | doaj-art-d7dacedf8fcc4455bd25a72bf32f17e4 |
| institution | Kabale University |
| issn | 2073-4409 |
| language | English |
| publishDate | 2025-07-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-d7dacedf8fcc4455bd25a72bf32f17e42025-08-20T03:58:31ZengMDPI AGCells2073-44092025-07-011414109110.3390/cells14141091Natural Killer (NK) Cell Alloreactivity in Haploidentical Stem Cell TransplantationMar Luis-Hidalgo0José Luis Piñana1Carlos Solano2Dolores Planelles3Centro de Transfusión de la Comunidad Valenciana, 46014 Valencia, SpainHospital Clínico Universitario de Valencia, 46010 Valencia, SpainHospital Clínico Universitario de Valencia, 46010 Valencia, SpainCentro de Transfusión de la Comunidad Valenciana, 46014 Valencia, SpainThis paper conducts a literature review on the role of natural killer cells in haploidentical hematopoietic stem cell transplantation. Theoretical concepts related to <i>KIR</i> genes are introduced regarding their structure, nomenclature, genetic organization, polymorphism, and inheritance pattern, types of KIR proteins and receptors, HLA ligands for KIR receptors, and the definition of different NK alloreactivity prediction models for the donor of haploidentical hematopoietic stem cell transplantation and the recipient. These models include the following and consider incompatibility: ligand–ligand, receptor–ligand, gene–gene, and KIR haplotype models or the <i>KIR-B</i> donor group. These models consider the presence or absence of specific ligands or receptors and/or <i>KIR</i> genes in the donor and recipient to predict alloreactivity. Determining the best model for predicting KIR alloreactivity and its significance in donor selection algorithms for haploidentical transplantation is still under investigation.https://www.mdpi.com/2073-4409/14/14/1091alloreactivitynatural killerhaploidentical hematopoietic stem cell transplantation |
| spellingShingle | Mar Luis-Hidalgo José Luis Piñana Carlos Solano Dolores Planelles Natural Killer (NK) Cell Alloreactivity in Haploidentical Stem Cell Transplantation Cells alloreactivity natural killer haploidentical hematopoietic stem cell transplantation |
| title | Natural Killer (NK) Cell Alloreactivity in Haploidentical Stem Cell Transplantation |
| title_full | Natural Killer (NK) Cell Alloreactivity in Haploidentical Stem Cell Transplantation |
| title_fullStr | Natural Killer (NK) Cell Alloreactivity in Haploidentical Stem Cell Transplantation |
| title_full_unstemmed | Natural Killer (NK) Cell Alloreactivity in Haploidentical Stem Cell Transplantation |
| title_short | Natural Killer (NK) Cell Alloreactivity in Haploidentical Stem Cell Transplantation |
| title_sort | natural killer nk cell alloreactivity in haploidentical stem cell transplantation |
| topic | alloreactivity natural killer haploidentical hematopoietic stem cell transplantation |
| url | https://www.mdpi.com/2073-4409/14/14/1091 |
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