Genome Sequence of Canine Herpesvirus.
Canine herpesvirus is a widespread alphaherpesvirus that causes a fatal haemorrhagic disease of neonatal puppies. We have used high-throughput methods to determine the genome sequences of three viral strains (0194, V777 and V1154) isolated in the United Kingdom between 1985 and 2000. The sequences a...
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Public Library of Science (PLoS)
2016-01-01
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| Series: | PLoS ONE |
| Online Access: | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0156015&type=printable |
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| author | Konstantinos V Papageorgiou Nicolás M Suárez Gavin S Wilkie Michael McDonald Elizabeth M Graham Andrew J Davison |
| author_facet | Konstantinos V Papageorgiou Nicolás M Suárez Gavin S Wilkie Michael McDonald Elizabeth M Graham Andrew J Davison |
| author_sort | Konstantinos V Papageorgiou |
| collection | DOAJ |
| description | Canine herpesvirus is a widespread alphaherpesvirus that causes a fatal haemorrhagic disease of neonatal puppies. We have used high-throughput methods to determine the genome sequences of three viral strains (0194, V777 and V1154) isolated in the United Kingdom between 1985 and 2000. The sequences are very closely related to each other. The canine herpesvirus genome is estimated to be 125 kbp in size and consists of a unique long sequence (97.5 kbp) and a unique short sequence (7.7 kbp) that are each flanked by terminal and internal inverted repeats (38 bp and 10.0 kbp, respectively). The overall nucleotide composition is 31.6% G+C, which is the lowest among the completely sequenced alphaherpesviruses. The genome contains 76 open reading frames predicted to encode functional proteins, all of which have counterparts in other alphaherpesviruses. The availability of the sequences will facilitate future research on the diagnosis and treatment of canine herpesvirus-associated disease. |
| format | Article |
| id | doaj-art-d7d72d35413c40c3a2afcdf2a1c68e81 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2016-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj-art-d7d72d35413c40c3a2afcdf2a1c68e812025-08-20T03:24:28ZengPublic Library of Science (PLoS)PLoS ONE1932-62032016-01-01115e015601510.1371/journal.pone.0156015Genome Sequence of Canine Herpesvirus.Konstantinos V PapageorgiouNicolás M SuárezGavin S WilkieMichael McDonaldElizabeth M GrahamAndrew J DavisonCanine herpesvirus is a widespread alphaherpesvirus that causes a fatal haemorrhagic disease of neonatal puppies. We have used high-throughput methods to determine the genome sequences of three viral strains (0194, V777 and V1154) isolated in the United Kingdom between 1985 and 2000. The sequences are very closely related to each other. The canine herpesvirus genome is estimated to be 125 kbp in size and consists of a unique long sequence (97.5 kbp) and a unique short sequence (7.7 kbp) that are each flanked by terminal and internal inverted repeats (38 bp and 10.0 kbp, respectively). The overall nucleotide composition is 31.6% G+C, which is the lowest among the completely sequenced alphaherpesviruses. The genome contains 76 open reading frames predicted to encode functional proteins, all of which have counterparts in other alphaherpesviruses. The availability of the sequences will facilitate future research on the diagnosis and treatment of canine herpesvirus-associated disease.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0156015&type=printable |
| spellingShingle | Konstantinos V Papageorgiou Nicolás M Suárez Gavin S Wilkie Michael McDonald Elizabeth M Graham Andrew J Davison Genome Sequence of Canine Herpesvirus. PLoS ONE |
| title | Genome Sequence of Canine Herpesvirus. |
| title_full | Genome Sequence of Canine Herpesvirus. |
| title_fullStr | Genome Sequence of Canine Herpesvirus. |
| title_full_unstemmed | Genome Sequence of Canine Herpesvirus. |
| title_short | Genome Sequence of Canine Herpesvirus. |
| title_sort | genome sequence of canine herpesvirus |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0156015&type=printable |
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