Peroxisome Proliferator-Activated Receptor -β/δ, -γ Agonists and Resveratrol Modulate Hypoxia Induced Changes in Nuclear Receptor Activators of Muscle Oxidative Metabolism

Peroxisome Proliferator-Activated Receptor -β/δ, -γ Agonists and Resveratrol Modulate Hypoxia Induced Changes in Nuclear Receptor Activators of Muscle Oxidative Metabolism

PPAR-α, PPAR-β, and PPAR-γ, and RXR in conjunction with PGC-1α and SIRT1, activate oxidative metabolism genes determining insulin sensitivity. In utero, hypoxia is commonly observed in Intrauterine Growth Restriction (IUGR), and reduced insulin sensitivity is often observed in these infants as adult...

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Main Authors: Timothy R. H. Regnault, Lin Zhao, Jacky S. S. Chiu, Stephanie K. Gottheil, Allison Foran, Siu-Pok Yee
Format: Article
Language:English
Published: Wiley 2010-01-01
Series:PPAR Research
Online Access:http://dx.doi.org/10.1155/2010/129173
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