Small Fiber Neuropathy: Clinicopathological Correlations
Small fiber neuropathy develops due to the selective damage of the thin fibers of peripheral nerves. Many common diseases can cause this condition, including diabetes, infections, autoimmune and endocrine disorders, but it can occur due to genetic alterations, as well. Eighty-five skin biopsy-proven...
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| Format: | Article |
| Language: | English |
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Wiley
2020-01-01
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| Series: | Behavioural Neurology |
| Online Access: | http://dx.doi.org/10.1155/2020/8796519 |
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| author | Endre Pál Krisztina Fülöp Péter Tóth Gabriella Deli Zoltán Pfund József Janszky Sámuel Komoly |
| author_facet | Endre Pál Krisztina Fülöp Péter Tóth Gabriella Deli Zoltán Pfund József Janszky Sámuel Komoly |
| author_sort | Endre Pál |
| collection | DOAJ |
| description | Small fiber neuropathy develops due to the selective damage of the thin fibers of peripheral nerves. Many common diseases can cause this condition, including diabetes, infections, autoimmune and endocrine disorders, but it can occur due to genetic alterations, as well. Eighty-five skin biopsy-proven small-fiber neuropathy cases were analyzed. Forty-one (48%) cases were idiopathic; among secondary types, hypothyreosis (9.4%), diabetes mellitus (7%), cryoglobulinemia (7%), monoclonal gammopathy with unproved significance (4.7%), Sjögren’s disease (3%), and paraneoplastic neuropathy (3%) were the most common causes. Two-thirds (68%) of the patients were female, and the secondary type started 8 years later than the idiopathic one. In a vast majority of the cases (85%), the distribution followed a length-dependent pattern. Intraepidermal fiber density was comparable in idiopathic and secondary forms. Of note, we found significantly more severe pathology in men and in diabetes. Weak correlation was found between patient-reported measures and pathology, as well as with neuropathic pain-related scores. Our study confirmed the significance of small fiber damage-caused neuropathic symptoms in many clinical conditions, the gender differences in clinical settings, and pathological alterations, as well as the presence of severe small fiber pathology in diabetes mellitus, one of the most common causes of peripheral neuropathy. |
| format | Article |
| id | doaj-art-d7d3a1f664864dc8bbcac08ae95c3b96 |
| institution | DOAJ |
| issn | 0953-4180 1875-8584 |
| language | English |
| publishDate | 2020-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Behavioural Neurology |
| spelling | doaj-art-d7d3a1f664864dc8bbcac08ae95c3b962025-08-20T03:23:52ZengWileyBehavioural Neurology0953-41801875-85842020-01-01202010.1155/2020/87965198796519Small Fiber Neuropathy: Clinicopathological CorrelationsEndre Pál0Krisztina Fülöp1Péter Tóth2Gabriella Deli3Zoltán Pfund4József Janszky5Sámuel Komoly6Department of Neurology, University of Pécs, Medical School, Pécs, HungaryDepartment of Pathology, Neuropathology Unit, University of Pécs, Medical School, Pécs, HungaryDepartment of Neurology, University of Pécs, Medical School, Pécs, HungaryDepartment of Neurology, University of Pécs, Medical School, Pécs, HungaryDepartment of Neurology, University of Pécs, Medical School, Pécs, HungaryDepartment of Neurology, University of Pécs, Medical School, Pécs, HungaryDepartment of Neurology, University of Pécs, Medical School, Pécs, HungarySmall fiber neuropathy develops due to the selective damage of the thin fibers of peripheral nerves. Many common diseases can cause this condition, including diabetes, infections, autoimmune and endocrine disorders, but it can occur due to genetic alterations, as well. Eighty-five skin biopsy-proven small-fiber neuropathy cases were analyzed. Forty-one (48%) cases were idiopathic; among secondary types, hypothyreosis (9.4%), diabetes mellitus (7%), cryoglobulinemia (7%), monoclonal gammopathy with unproved significance (4.7%), Sjögren’s disease (3%), and paraneoplastic neuropathy (3%) were the most common causes. Two-thirds (68%) of the patients were female, and the secondary type started 8 years later than the idiopathic one. In a vast majority of the cases (85%), the distribution followed a length-dependent pattern. Intraepidermal fiber density was comparable in idiopathic and secondary forms. Of note, we found significantly more severe pathology in men and in diabetes. Weak correlation was found between patient-reported measures and pathology, as well as with neuropathic pain-related scores. Our study confirmed the significance of small fiber damage-caused neuropathic symptoms in many clinical conditions, the gender differences in clinical settings, and pathological alterations, as well as the presence of severe small fiber pathology in diabetes mellitus, one of the most common causes of peripheral neuropathy.http://dx.doi.org/10.1155/2020/8796519 |
| spellingShingle | Endre Pál Krisztina Fülöp Péter Tóth Gabriella Deli Zoltán Pfund József Janszky Sámuel Komoly Small Fiber Neuropathy: Clinicopathological Correlations Behavioural Neurology |
| title | Small Fiber Neuropathy: Clinicopathological Correlations |
| title_full | Small Fiber Neuropathy: Clinicopathological Correlations |
| title_fullStr | Small Fiber Neuropathy: Clinicopathological Correlations |
| title_full_unstemmed | Small Fiber Neuropathy: Clinicopathological Correlations |
| title_short | Small Fiber Neuropathy: Clinicopathological Correlations |
| title_sort | small fiber neuropathy clinicopathological correlations |
| url | http://dx.doi.org/10.1155/2020/8796519 |
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