The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma
Abstract This study aimed at evaluating the diagnostic and prognostic role of neopterin (Npt) concentration in the cerebrospinal fluid (CSF) of patients with primary central nervous system lymphoma (PCNSL). Ninety‐nine patients were enrolled in this retrospective study; these included patients with...
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| Format: | Article |
| Language: | English |
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Wiley
2018-08-01
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| Series: | Cancer Medicine |
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| Online Access: | https://doi.org/10.1002/cam4.1581 |
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| author | Mingying Geng He Xiao Jiaqi Liu Yang Song Ping Fu Xing Cheng Jinwei Zhang Ge Wang |
| author_facet | Mingying Geng He Xiao Jiaqi Liu Yang Song Ping Fu Xing Cheng Jinwei Zhang Ge Wang |
| author_sort | Mingying Geng |
| collection | DOAJ |
| description | Abstract This study aimed at evaluating the diagnostic and prognostic role of neopterin (Npt) concentration in the cerebrospinal fluid (CSF) of patients with primary central nervous system lymphoma (PCNSL). Ninety‐nine patients were enrolled in this retrospective study; these included patients with PCNSL (n = 21), other brain tumors (n = 44), and inflammatory diseases (n = 34). CSF Npt concentration was measured using ELISA. Receiver operating characteristic (ROC) curve analysis was performed to assess the discriminative ability of CSF Npt concentration for the diagnosis of PCNSL. CSF Npt concentration in patients with PCNSL was significantly higher than that in patients with other brain tumors and inflammatory diseases (P < .001). On ROC curve analysis, the optimal cutoff CSF Npt level of 10.77 ng/mL for the diagnosis of PCNSL and the diagnostic yield of MRI were increased when used in conjunction with CSF Npt concentration. The CSF Npt concentrations in PCNSL patients with multiple lesions were significantly higher than those in patients with a single lesion. Changes in CSF Npt concentration were consistent with post‐treatment changes in tumor sizes. The CSF Npt concentration may be a good biomarker for the diagnosis, for monitoring of disease course, and for prognostic evaluation of patients with PCNSL. |
| format | Article |
| id | doaj-art-d7d22d2c020446428d7ed0190e2aa24c |
| institution | OA Journals |
| issn | 2045-7634 |
| language | English |
| publishDate | 2018-08-01 |
| publisher | Wiley |
| record_format | Article |
| series | Cancer Medicine |
| spelling | doaj-art-d7d22d2c020446428d7ed0190e2aa24c2025-08-20T01:58:43ZengWileyCancer Medicine2045-76342018-08-01783889389810.1002/cam4.1581The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphomaMingying Geng0He Xiao1Jiaqi Liu2Yang Song3Ping Fu4Xing Cheng5Jinwei Zhang6Ge Wang7Cancer Center Institute of Surgery Research Third Affiliated Hospital Army Medical University (Third Military Medical University) Chongqing ChinaCancer Center Institute of Surgery Research Third Affiliated Hospital Army Medical University (Third Military Medical University) Chongqing ChinaDepartment of Clinical Laboratory Institute of Surgery Research Third Affiliated Hospital Army Medical University (Third Military Medical University) Chongqing ChinaCancer Center Institute of Surgery Research Third Affiliated Hospital Army Medical University (Third Military Medical University) Chongqing ChinaDepartment of Pathology Institute of Surgery Research Third Affiliated Hospital Army Medical University (Third Military Medical University) Chongqin ChinaDepartment of Neurosurgery Chongqing Cancer Hospital Chongqing ChinaDepartment of Neurosurgery The Second Affiliated Hospital of Harbin Medical University Harbin Heilongjiang ChinaCancer Center Institute of Surgery Research Third Affiliated Hospital Army Medical University (Third Military Medical University) Chongqing ChinaAbstract This study aimed at evaluating the diagnostic and prognostic role of neopterin (Npt) concentration in the cerebrospinal fluid (CSF) of patients with primary central nervous system lymphoma (PCNSL). Ninety‐nine patients were enrolled in this retrospective study; these included patients with PCNSL (n = 21), other brain tumors (n = 44), and inflammatory diseases (n = 34). CSF Npt concentration was measured using ELISA. Receiver operating characteristic (ROC) curve analysis was performed to assess the discriminative ability of CSF Npt concentration for the diagnosis of PCNSL. CSF Npt concentration in patients with PCNSL was significantly higher than that in patients with other brain tumors and inflammatory diseases (P < .001). On ROC curve analysis, the optimal cutoff CSF Npt level of 10.77 ng/mL for the diagnosis of PCNSL and the diagnostic yield of MRI were increased when used in conjunction with CSF Npt concentration. The CSF Npt concentrations in PCNSL patients with multiple lesions were significantly higher than those in patients with a single lesion. Changes in CSF Npt concentration were consistent with post‐treatment changes in tumor sizes. The CSF Npt concentration may be a good biomarker for the diagnosis, for monitoring of disease course, and for prognostic evaluation of patients with PCNSL.https://doi.org/10.1002/cam4.1581biomarkerbrain tumorcerebrospinal fluidinflammationneopterinprimary central nervous system lymphoma |
| spellingShingle | Mingying Geng He Xiao Jiaqi Liu Yang Song Ping Fu Xing Cheng Jinwei Zhang Ge Wang The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma Cancer Medicine biomarker brain tumor cerebrospinal fluid inflammation neopterin primary central nervous system lymphoma |
| title | The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma |
| title_full | The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma |
| title_fullStr | The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma |
| title_full_unstemmed | The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma |
| title_short | The diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma |
| title_sort | diagnostic role and dynamic changes in cerebrospinal fluid neopterin during treatment of patients with primary central nervous system lymphoma |
| topic | biomarker brain tumor cerebrospinal fluid inflammation neopterin primary central nervous system lymphoma |
| url | https://doi.org/10.1002/cam4.1581 |
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