Prevalence and Determinants of Major Depressive Disorder among Patients with Sickle Cell Disease
Background: Sickle cell disease (SCD) is the most common genetic disorder globally, with sub-Saharan Africa, particularly Nigeria, bearing the highest prevalence. Depression can significantly impact SCD patients, reducing their quality of life and increasing morbidity and mortality. Aim: This study...
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| Main Authors: | , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wolters Kluwer Medknow Publications
2024-04-01
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| Series: | Nigerian Journal of Medicine |
| Subjects: | |
| Online Access: | https://journals.lww.com/10.4103/NJM.NJM_47_24 |
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| Summary: | Background:
Sickle cell disease (SCD) is the most common genetic disorder globally, with sub-Saharan Africa, particularly Nigeria, bearing the highest prevalence. Depression can significantly impact SCD patients, reducing their quality of life and increasing morbidity and mortality.
Aim:
This study aims to determine the prevalence and determinants of major depressive disorder (MDD) among patients with SCD.
Methodology:
This cross-sectional study was conducted at the Usmanu Danfodiyo University Teaching Hospital in Sokoto. An in-depth, interviewer-administered questionnaire was used to interview SCD patients who were recruited through systematic sampling.
Results:
The prevalence of MDD was 21.8%, 95% confidence interval (16.4, 28.1%) with 18.9%, 1.9% and 1% having mild, moderate and severe depression, respectively. Depression was significantly associated with low social support (P = 0.007), low level of education (P < 0.001) and a higher pain score (P = 0.001), but not with gender (P = 0.730), haemoglobin type (P = 0.274), or the use of hydroxyurea (P = 1.000). All three variables that entered binary logistic regression were determinants of MDD, i.e. level of education, social support and pain score.
Conclusion:
The study found that the prevalence of MDD was high among patients with SCD. In addition, the researchers determined that level of education, social support and pain were important determinants of MDD in this patient population. The findings highlight the need to screen for depression among patients with SCD. |
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| ISSN: | 1115-2613 2667-0526 |