Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia

Bridging animal models and humans: neuroimaging as intermediate phenotypes linking genetic or stress factors to anhedonia

Abstract Background Intermediate phenotypes, such as characteristic neuroimaging patterns, offer unique insights into the genetic and stress-related underpinnings of neuropsychiatric disorders like depression. This study aimed to identify neuroimaging intermediate phenotypes associated with depressi...

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Main Authors: Huiling Guo, Yao Xiao, Shuai Dong, Jingyu Yang, Pengfei Zhao, Tongtong Zhao, Aoling Cai, Lili Tang, Juan Liu, Hui Wang, Ruifang Hua, Rongxun Liu, Yange Wei, Dandan Sun, Zhongchun Liu, Mingrui Xia, Yong He, Yankun Wu, Tianmei Si, Fay Y. Womer, Fuqiang Xu, Yanqing Tang, Jie Wang, Weixiong Zhang, Xizhe Zhang, Fei Wang
Format: Article
Language:English
Published: BMC 2025-01-01
Series:BMC Medicine
Subjects:
Depression
Subtypes
Animal
Neuroimaging
Intermediate phenotypes
Cross-species
Online Access:https://doi.org/10.1186/s12916-025-03850-4
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