Impact of cysteine mutations on the structural dynamics and functional impairment of SOD1: insights into the pathogenicity of amyotrophic lateral sclerosis

Impact of cysteine mutations on the structural dynamics and functional impairment of SOD1: insights into the pathogenicity of amyotrophic lateral sclerosis

Abstract Amyotrophic lateral sclerosis (ALS) is a rare neurodegenerative disease prevalent in American and European populations, with its onset and progression significantly influenced by mutations in the superoxide dismutase 1 (SOD1) protein. While previous studies have highlighted the effects of m...

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Bibliographic Details
Main Authors: Jessica Jeejan, Lawanya Rao, Shivank Sadasivan, Richa Lopes, Norine Dsouza
Format: Article
Language:English
Published: BioMed Central 2025-03-01
Series:Genomics & Informatics
Subjects:
ALS
Missense mutations
Neurodegenerative
SOD1
Dimerisation
Online Access:https://doi.org/10.1186/s44342-025-00041-8
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