Design of Ig-like binders targeting α-synuclein fibril for mitigating its pathological activities

Design of Ig-like binders targeting α-synuclein fibril for mitigating its pathological activities

Abstract Parkinson’s disease (PD) is characterized by the accumulation and spread of pathological α-synuclein (α-syn) fibrils, which contribute to neuroinflammation and neurodegeneration. Here we show that two immunoglobulin-like (Ig-like) domains derived from α-syn receptors, the D1 domain of lymph...

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Bibliographic Details
Main Authors: Shuyi Zeng, Xingyu Xiong, Houfang Long, Qianhui Xu, Yifan Yu, Bo Sun, Cong Liu, Zhizhi Wang, Wenqing Xu, Shengnan Zhang, Dan Li
Format: Article
Language:English
Published: Nature Portfolio 2025-08-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-62755-1
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