Comprehensive analysis of Atypical chronic myeloid leukemia (aCML): Epidemiology, clinical features, and survival outcomes based on SEER database insights
Background: Atypical Chronic Myeloid Leukemia (aCML) is a rare and aggressive myelodysplastic syndrome/myeloproliferative neoplasm. This study aimed to provide a comprehensive understanding of the epidemiology, clinical characteristics, and survival outcomes of aCML patients. Methods: The study util...
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Elsevier
2025-01-01
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| Series: | Leukemia Research Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S221304892500007X |
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| author | Zhaoyang Hong Fan Wang |
| author_facet | Zhaoyang Hong Fan Wang |
| author_sort | Zhaoyang Hong |
| collection | DOAJ |
| description | Background: Atypical Chronic Myeloid Leukemia (aCML) is a rare and aggressive myelodysplastic syndrome/myeloproliferative neoplasm. This study aimed to provide a comprehensive understanding of the epidemiology, clinical characteristics, and survival outcomes of aCML patients. Methods: The study utilized data from the Surveillance, Epidemiology, and End Results (SEER) database from 2001 to 2020. The age-adjusted incidence rate (AIR) of aCML was calculated, and survival outcomes were analyzed using the Kaplan-Meier method and accelerated failure time (AFT) regression analysis. Results: The AIR of aCML was found to be 0.024 per 100,000 person-years, with the highest rate observed in 2020. The incidence of aCML increased with age and was higher in males. The study cohort predominantly consisted of elderly White individuals, with an average age at diagnosis of 68.2 ± 15.3 years. The median overall survival (OS) and disease-specific survival (DSS) were 1.4 years and 1.7 years, respectively. Older age was independently associated with worse survival outcomes. Notably, treatment delay and chemotherapy did not significantly impact OS or DSS. Conclusions: This study provides comprehensive insights into the epidemiology, clinical characteristics, and survival outcomes of aCML, highlighting its rarity, aggressive nature, and poor prognosis. Further research is needed to validate these findings and explore novel therapeutic strategies for improving outcomes in this challenging hematologic malignancy. |
| format | Article |
| id | doaj-art-d7be9217b3964b8baeb7a4c0af535083 |
| institution | OA Journals |
| issn | 2213-0489 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Leukemia Research Reports |
| spelling | doaj-art-d7be9217b3964b8baeb7a4c0af5350832025-08-20T02:37:03ZengElsevierLeukemia Research Reports2213-04892025-01-012310050510.1016/j.lrr.2025.100505Comprehensive analysis of Atypical chronic myeloid leukemia (aCML): Epidemiology, clinical features, and survival outcomes based on SEER database insightsZhaoyang Hong0Fan Wang1Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, ChinaDepartment of Hematology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, China; Corresponding author.Background: Atypical Chronic Myeloid Leukemia (aCML) is a rare and aggressive myelodysplastic syndrome/myeloproliferative neoplasm. This study aimed to provide a comprehensive understanding of the epidemiology, clinical characteristics, and survival outcomes of aCML patients. Methods: The study utilized data from the Surveillance, Epidemiology, and End Results (SEER) database from 2001 to 2020. The age-adjusted incidence rate (AIR) of aCML was calculated, and survival outcomes were analyzed using the Kaplan-Meier method and accelerated failure time (AFT) regression analysis. Results: The AIR of aCML was found to be 0.024 per 100,000 person-years, with the highest rate observed in 2020. The incidence of aCML increased with age and was higher in males. The study cohort predominantly consisted of elderly White individuals, with an average age at diagnosis of 68.2 ± 15.3 years. The median overall survival (OS) and disease-specific survival (DSS) were 1.4 years and 1.7 years, respectively. Older age was independently associated with worse survival outcomes. Notably, treatment delay and chemotherapy did not significantly impact OS or DSS. Conclusions: This study provides comprehensive insights into the epidemiology, clinical characteristics, and survival outcomes of aCML, highlighting its rarity, aggressive nature, and poor prognosis. Further research is needed to validate these findings and explore novel therapeutic strategies for improving outcomes in this challenging hematologic malignancy.http://www.sciencedirect.com/science/article/pii/S221304892500007XAtypical chronic myeloid leukemiaEpidemiologySurvivalSEER database, Accelerated failure time (AFT) regression analysis |
| spellingShingle | Zhaoyang Hong Fan Wang Comprehensive analysis of Atypical chronic myeloid leukemia (aCML): Epidemiology, clinical features, and survival outcomes based on SEER database insights Leukemia Research Reports Atypical chronic myeloid leukemia Epidemiology Survival SEER database, Accelerated failure time (AFT) regression analysis |
| title | Comprehensive analysis of Atypical chronic myeloid leukemia (aCML): Epidemiology, clinical features, and survival outcomes based on SEER database insights |
| title_full | Comprehensive analysis of Atypical chronic myeloid leukemia (aCML): Epidemiology, clinical features, and survival outcomes based on SEER database insights |
| title_fullStr | Comprehensive analysis of Atypical chronic myeloid leukemia (aCML): Epidemiology, clinical features, and survival outcomes based on SEER database insights |
| title_full_unstemmed | Comprehensive analysis of Atypical chronic myeloid leukemia (aCML): Epidemiology, clinical features, and survival outcomes based on SEER database insights |
| title_short | Comprehensive analysis of Atypical chronic myeloid leukemia (aCML): Epidemiology, clinical features, and survival outcomes based on SEER database insights |
| title_sort | comprehensive analysis of atypical chronic myeloid leukemia acml epidemiology clinical features and survival outcomes based on seer database insights |
| topic | Atypical chronic myeloid leukemia Epidemiology Survival SEER database, Accelerated failure time (AFT) regression analysis |
| url | http://www.sciencedirect.com/science/article/pii/S221304892500007X |
| work_keys_str_mv | AT zhaoyanghong comprehensiveanalysisofatypicalchronicmyeloidleukemiaacmlepidemiologyclinicalfeaturesandsurvivaloutcomesbasedonseerdatabaseinsights AT fanwang comprehensiveanalysisofatypicalchronicmyeloidleukemiaacmlepidemiologyclinicalfeaturesandsurvivaloutcomesbasedonseerdatabaseinsights |