Optic neuritis: relation between inflammatory genetic markers and occurrence of the disease
Optic neuritis (ON) is characterized as an inflammation of the optic nerve. Based on etiology, ON is classified to typical and atypical forms. Typical ON is often related to multiple sclerosis while atypical ON can be caused by various infections, autoimmune disorders or different inflammatory dise...
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| Format: | Article |
| Language: | English |
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Vilnius University Press
2019-09-01
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| Series: | Neurologijos seminarai |
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| Online Access: | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27772 |
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| author | V. Punytė R. Liutkevičienė |
| author_facet | V. Punytė R. Liutkevičienė |
| author_sort | V. Punytė |
| collection | DOAJ |
| description |
Optic neuritis (ON) is characterized as an inflammation of the optic nerve. Based on etiology, ON is classified to typical and atypical forms. Typical ON is often related to multiple sclerosis while atypical ON can be caused by various infections, autoimmune disorders or different inflammatory diseases. Although the cause of ON is multifactorial, a lot of attention is given to inflammatory and immune processes which are considered to contribute to demyelination of axons. Typical ON occurs as subacute unilateral decrease in visual acuity (VA) and pain which intensifies during eye movement. Atypical ON is characterized by intense pain or no pain, bilateral decrease in VA, hemorrhages and exudate in optic discs. In typical ON, fast and significant recovery of VA is common while in atypical ON, the prognosis of VA recovery is poor. Thanks to recent advances in the field of genetics, it is possible to identify an increasing number of genes that could be associated with ON pathogenesis.
In this article we briefly review the epidemiology, causes, pathophysiology, symptoms, diagnostics and treatment of ON as well as its relation to multiple sclerosis.
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| format | Article |
| id | doaj-art-d7bce27b95ef44a2b5bfd70eae7cb0e6 |
| institution | Kabale University |
| issn | 1392-3064 2424-5917 |
| language | English |
| publishDate | 2019-09-01 |
| publisher | Vilnius University Press |
| record_format | Article |
| series | Neurologijos seminarai |
| spelling | doaj-art-d7bce27b95ef44a2b5bfd70eae7cb0e62025-01-20T18:22:58ZengVilnius University PressNeurologijos seminarai1392-30642424-59172019-09-01233(81)10.29014/ns.2019.16Optic neuritis: relation between inflammatory genetic markers and occurrence of the diseaseV. Punytė 0R. Liutkevičienė 1Lithuanian University of Health SciencesLithuanian University of Health Sciences Optic neuritis (ON) is characterized as an inflammation of the optic nerve. Based on etiology, ON is classified to typical and atypical forms. Typical ON is often related to multiple sclerosis while atypical ON can be caused by various infections, autoimmune disorders or different inflammatory diseases. Although the cause of ON is multifactorial, a lot of attention is given to inflammatory and immune processes which are considered to contribute to demyelination of axons. Typical ON occurs as subacute unilateral decrease in visual acuity (VA) and pain which intensifies during eye movement. Atypical ON is characterized by intense pain or no pain, bilateral decrease in VA, hemorrhages and exudate in optic discs. In typical ON, fast and significant recovery of VA is common while in atypical ON, the prognosis of VA recovery is poor. Thanks to recent advances in the field of genetics, it is possible to identify an increasing number of genes that could be associated with ON pathogenesis. In this article we briefly review the epidemiology, causes, pathophysiology, symptoms, diagnostics and treatment of ON as well as its relation to multiple sclerosis. https://www.journals.vu.lt/neurologijos_seminarai/article/view/27772optic neuritissymptomsdiagnosticstreatmentmultiple sclerosisIL-6 |
| spellingShingle | V. Punytė R. Liutkevičienė Optic neuritis: relation between inflammatory genetic markers and occurrence of the disease Neurologijos seminarai optic neuritis symptoms diagnostics treatment multiple sclerosis IL-6 |
| title | Optic neuritis: relation between inflammatory genetic markers and occurrence of the disease |
| title_full | Optic neuritis: relation between inflammatory genetic markers and occurrence of the disease |
| title_fullStr | Optic neuritis: relation between inflammatory genetic markers and occurrence of the disease |
| title_full_unstemmed | Optic neuritis: relation between inflammatory genetic markers and occurrence of the disease |
| title_short | Optic neuritis: relation between inflammatory genetic markers and occurrence of the disease |
| title_sort | optic neuritis relation between inflammatory genetic markers and occurrence of the disease |
| topic | optic neuritis symptoms diagnostics treatment multiple sclerosis IL-6 |
| url | https://www.journals.vu.lt/neurologijos_seminarai/article/view/27772 |
| work_keys_str_mv | AT vpunyte opticneuritisrelationbetweeninflammatorygeneticmarkersandoccurrenceofthedisease AT rliutkeviciene opticneuritisrelationbetweeninflammatorygeneticmarkersandoccurrenceofthedisease |