Reliea® combination of Codonopsis lanceolata and Chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles (PM10D) ‑induced respiratory disease mouse model
Particulate matter (PM, diameter < 10 μm) and Diesel exhaust particles (DEP) exposure can cause severe respiratory disorders. This investigation explored the protective effects of Reliea® (RelA), combination of Codonopsis lanceolata and Chaenomeles sinensis extract, against airway inflammation re...
Saved in:
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
Elsevier
2025-01-01
|
| Series: | Ecotoxicology and Environmental Safety |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S0147651324016142 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1823856940108742656 |
|---|---|
| author | Yoon-Young Sung Won-Kyung Yang Jong Hoon Kim Dongseok Shin Seok June Son Seung-Hyung Kim |
| author_facet | Yoon-Young Sung Won-Kyung Yang Jong Hoon Kim Dongseok Shin Seok June Son Seung-Hyung Kim |
| author_sort | Yoon-Young Sung |
| collection | DOAJ |
| description | Particulate matter (PM, diameter < 10 μm) and Diesel exhaust particles (DEP) exposure can cause severe respiratory disorders. This investigation explored the protective effects of Reliea® (RelA), combination of Codonopsis lanceolata and Chaenomeles sinensis extract, against airway inflammation related to PM10D exposure. RelA treatment suppressed reactive oxygen species, nitric oxide release, cytokine expression (IL-6, IL-1β, iNOS, CXCL-2, MCP-1, and TNF-α), and the related inflammatory mechanisms in PM10-induced alveolar macrophage cells. BALB/c mice were injected with PM10D via intranasal trachea three times over a period of 12 days and RelA were orally dispensed for 12 days. RelA inhibited infiltrating neutrophils, total number of immunocytes in lung and bronchoalveolar lavage fluid (BALF). RelA decreased the expression of interleukin (IL)-17, chemokine (C-X-C motif) ligand (CXCL)-1, thymus and activation-regulated chemokine, macrophage inflammatory protein-2, IL-1α, TNF-α, mucin 5AC, cyclooxygenase-2, and transient receptor potential cation channel subfamily A or V member 1 in BALF and lung, and inhibited IL-1α and macrophage marker F4/80 localization in lung of PM10D-induced mice. RelA treatment decreased serum symmetric dimethyl arginine levels. RelA restored histopathological damage via inhibition of NF-κB and MAPK pathways in the trachea and lung. Lancemaside A and protocatechuic acid as major active compounds of RelA was identified. In addition, RelA showed better expectoration through increased phenol red secretion. These results indicate that Reliea® combination of C. lanceolata and C. sinensis extract might be effective in prevention and treatment of airway inflammation and respiratory diseases. |
| format | Article |
| id | doaj-art-d7bb9ecbc82348cfb74b2f70414416e1 |
| institution | Kabale University |
| issn | 0147-6513 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Ecotoxicology and Environmental Safety |
| spelling | doaj-art-d7bb9ecbc82348cfb74b2f70414416e12025-02-12T05:29:34ZengElsevierEcotoxicology and Environmental Safety0147-65132025-01-01290117538Reliea® combination of Codonopsis lanceolata and Chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles (PM10D) ‑induced respiratory disease mouse modelYoon-Young Sung0Won-Kyung Yang1Jong Hoon Kim2Dongseok Shin3Seok June Son4Seung-Hyung Kim5KM Science Research Division, Korea Institute of Oriental Medicine, 1672 Yuseongdae-ro, Yuseong-gu, Daejeon 34054, Republic of KoreaInstitute of Traditional Medicine and Bioscience, Daejeon University, Daejeon 34520, Republic of KoreaNongshim, R&D Center, 112 (Shindaebang-Dong), Yeouidaebang-Ro, Dongjak-Gu, Seoul, Republic of KoreaNongshim, R&D Center, 112 (Shindaebang-Dong), Yeouidaebang-Ro, Dongjak-Gu, Seoul, Republic of KoreaNongshim, R&D Center, 112 (Shindaebang-Dong), Yeouidaebang-Ro, Dongjak-Gu, Seoul, Republic of KoreaInstitute of Traditional Medicine and Bioscience, Daejeon University, Daejeon 34520, Republic of Korea; Corresponding author.Particulate matter (PM, diameter < 10 μm) and Diesel exhaust particles (DEP) exposure can cause severe respiratory disorders. This investigation explored the protective effects of Reliea® (RelA), combination of Codonopsis lanceolata and Chaenomeles sinensis extract, against airway inflammation related to PM10D exposure. RelA treatment suppressed reactive oxygen species, nitric oxide release, cytokine expression (IL-6, IL-1β, iNOS, CXCL-2, MCP-1, and TNF-α), and the related inflammatory mechanisms in PM10-induced alveolar macrophage cells. BALB/c mice were injected with PM10D via intranasal trachea three times over a period of 12 days and RelA were orally dispensed for 12 days. RelA inhibited infiltrating neutrophils, total number of immunocytes in lung and bronchoalveolar lavage fluid (BALF). RelA decreased the expression of interleukin (IL)-17, chemokine (C-X-C motif) ligand (CXCL)-1, thymus and activation-regulated chemokine, macrophage inflammatory protein-2, IL-1α, TNF-α, mucin 5AC, cyclooxygenase-2, and transient receptor potential cation channel subfamily A or V member 1 in BALF and lung, and inhibited IL-1α and macrophage marker F4/80 localization in lung of PM10D-induced mice. RelA treatment decreased serum symmetric dimethyl arginine levels. RelA restored histopathological damage via inhibition of NF-κB and MAPK pathways in the trachea and lung. Lancemaside A and protocatechuic acid as major active compounds of RelA was identified. In addition, RelA showed better expectoration through increased phenol red secretion. These results indicate that Reliea® combination of C. lanceolata and C. sinensis extract might be effective in prevention and treatment of airway inflammation and respiratory diseases.http://www.sciencedirect.com/science/article/pii/S0147651324016142MH-SCombination of Codonopsis lanceolata and Chaenomeles sinensisParticulate matterDiesel exhaust particlesAirway InflammationLancemaside A |
| spellingShingle | Yoon-Young Sung Won-Kyung Yang Jong Hoon Kim Dongseok Shin Seok June Son Seung-Hyung Kim Reliea® combination of Codonopsis lanceolata and Chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles (PM10D) ‑induced respiratory disease mouse model Ecotoxicology and Environmental Safety MH-S Combination of Codonopsis lanceolata and Chaenomeles sinensis Particulate matter Diesel exhaust particles Airway Inflammation Lancemaside A |
| title | Reliea® combination of Codonopsis lanceolata and Chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles (PM10D) ‑induced respiratory disease mouse model |
| title_full | Reliea® combination of Codonopsis lanceolata and Chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles (PM10D) ‑induced respiratory disease mouse model |
| title_fullStr | Reliea® combination of Codonopsis lanceolata and Chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles (PM10D) ‑induced respiratory disease mouse model |
| title_full_unstemmed | Reliea® combination of Codonopsis lanceolata and Chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles (PM10D) ‑induced respiratory disease mouse model |
| title_short | Reliea® combination of Codonopsis lanceolata and Chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles (PM10D) ‑induced respiratory disease mouse model |
| title_sort | reliea r combination of codonopsis lanceolata and chaenomeles sinensis extract alleviates airway inflammation on particulate matter 10 plus diesel exhaust particles pm10d induced respiratory disease mouse model |
| topic | MH-S Combination of Codonopsis lanceolata and Chaenomeles sinensis Particulate matter Diesel exhaust particles Airway Inflammation Lancemaside A |
| url | http://www.sciencedirect.com/science/article/pii/S0147651324016142 |
| work_keys_str_mv | AT yoonyoungsung relieacombinationofcodonopsislanceolataandchaenomelessinensisextractalleviatesairwayinflammationonparticulatematter10plusdieselexhaustparticlespm10dinducedrespiratorydiseasemousemodel AT wonkyungyang relieacombinationofcodonopsislanceolataandchaenomelessinensisextractalleviatesairwayinflammationonparticulatematter10plusdieselexhaustparticlespm10dinducedrespiratorydiseasemousemodel AT jonghoonkim relieacombinationofcodonopsislanceolataandchaenomelessinensisextractalleviatesairwayinflammationonparticulatematter10plusdieselexhaustparticlespm10dinducedrespiratorydiseasemousemodel AT dongseokshin relieacombinationofcodonopsislanceolataandchaenomelessinensisextractalleviatesairwayinflammationonparticulatematter10plusdieselexhaustparticlespm10dinducedrespiratorydiseasemousemodel AT seokjuneson relieacombinationofcodonopsislanceolataandchaenomelessinensisextractalleviatesairwayinflammationonparticulatematter10plusdieselexhaustparticlespm10dinducedrespiratorydiseasemousemodel AT seunghyungkim relieacombinationofcodonopsislanceolataandchaenomelessinensisextractalleviatesairwayinflammationonparticulatematter10plusdieselexhaustparticlespm10dinducedrespiratorydiseasemousemodel |