Case Report: Synergistic central nervous system depression of baclofen and pregabalin: clinical pharmacist-driven case analysis and case review

Case Report: Synergistic central nervous system depression of baclofen and pregabalin: clinical pharmacist-driven case analysis and case review

BackgroundBaclofen, a γ-aminobutyric acid (GABA) derivative, and Pregabalin, a GABA analogue, are widely prescribed for muscle spasm and neuropathic pain. This first-reported case demonstrates synergistic central nervous system (CNS) depression of Baclofen (30 mg/day) and Pregabalin (300 mg/day) in...

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Bibliographic Details
Main Authors: Yitong Xie, Danwei Wu, Peihao Jin, Lu Mao, Jiancun Zhen, Wei Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Pharmacology
Subjects:
baclofen
pregabalin
drug-induced CNS depression
renal impairment
synergistic toxicity
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2025.1598971/full
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