Urinary interleukin 13 level in steroid sensitive and resistant nephrotic syndrome: a cross-sectional single center study
Abstract Nephrotic syndrome, the most common glomerular disease in pediatric population, is classified into two groups of steroid sensitive (SSNS) and resistant (SSRS). There is growing evidence on the role of T cells cytokines, including interleukin-13, in pathophysiology of nephrotic syndrome and...
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Nature Portfolio
2025-02-01
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| Online Access: | https://doi.org/10.1038/s41598-025-86488-9 |
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| author | Behnam Ermian Noosha Samieefar Aida Vahidi Daryoush Fahimi Niloufar Peirovi Mohamed Husein Aldokhi Behnaz Bazargani Arash Abbasi Fahimeh Askarian Mastaneh Moghtaderi |
| author_facet | Behnam Ermian Noosha Samieefar Aida Vahidi Daryoush Fahimi Niloufar Peirovi Mohamed Husein Aldokhi Behnaz Bazargani Arash Abbasi Fahimeh Askarian Mastaneh Moghtaderi |
| author_sort | Behnam Ermian |
| collection | DOAJ |
| description | Abstract Nephrotic syndrome, the most common glomerular disease in pediatric population, is classified into two groups of steroid sensitive (SSNS) and resistant (SSRS). There is growing evidence on the role of T cells cytokines, including interleukin-13, in pathophysiology of nephrotic syndrome and steroid response. This study was a cross-sectional study conducted at Children’s Medical Center Hospital in order to explore the relationship between urinary IL-13 levels and responsiveness to corticosteroid treatment. All children (1 to 15 years) referred from January 2021 to January 2022 diagnosed with nephrotic syndrome were included. Urine samples were collected during the initial phase or relapse of nephrotic syndrome, before the initiation of steroid or alternative treatments. Interleukin-13 levels in the urine were measured using the ELISA method. In this study, 83 cases of nephrotic syndrome were enrolled, of whom 30 (36.1%) were girls and 53 (63.9%) were boys. Out of the 83 cases, 63 (75.9%) were identified as SSNS and 20 (24.1%) as SRNS. There was no significant difference between the urinary interleukin-13 levels between SSNS and SRNS groups (P-value: 0.84). Sex (P-value: 0.598) and age (P-value: 0.704) also had no association with interleukin-13 levels. Further studies in larger population are recommended to better assess the potential of this biomarker to predict response to treatment. . |
| format | Article |
| id | doaj-art-d7b9e2f7b2cc49a6b901edfb0621ac64 |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-d7b9e2f7b2cc49a6b901edfb0621ac642025-02-09T12:29:21ZengNature PortfolioScientific Reports2045-23222025-02-011511510.1038/s41598-025-86488-9Urinary interleukin 13 level in steroid sensitive and resistant nephrotic syndrome: a cross-sectional single center studyBehnam Ermian0Noosha Samieefar1Aida Vahidi2Daryoush Fahimi3Niloufar Peirovi4Mohamed Husein Aldokhi5Behnaz Bazargani6Arash Abbasi7Fahimeh Askarian8Mastaneh Moghtaderi9School of Medicine, Tehran University of Medical SciencesPediatric Chronic Kidney Disease Research Center, Gene, Cell & Tissue Research Institute, Children’s Medical Center, Tehran University of Medical SciencesMetabolic Disorders Research Center, Endocrinology and Metabolism Molecular- Cellular Sciences Institute, Tehran University of Medical SciencesPediatric Chronic Kidney Disease Research Center, Gene, Cell & Tissue Research Institute, Children’s Medical Center, Tehran University of Medical SciencesSchool of Medicine, Tehran University of Medical SciencesSchool of Medicine, Tehran University of Medical SciencesPediatric Chronic Kidney Disease Research Center, Gene, Cell & Tissue Research Institute, Children’s Medical Center, Tehran University of Medical SciencesPediatric Chronic Kidney Disease Research Center, Gene, Cell & Tissue Research Institute, Children’s Medical Center, Tehran University of Medical SciencesPediatric Chronic Kidney Disease Research Center, Gene, Cell & Tissue Research Institute, Children’s Medical Center, Tehran University of Medical SciencesPediatric Chronic Kidney Disease Research Center, Gene, Cell & Tissue Research Institute, Children’s Medical Center, Tehran University of Medical SciencesAbstract Nephrotic syndrome, the most common glomerular disease in pediatric population, is classified into two groups of steroid sensitive (SSNS) and resistant (SSRS). There is growing evidence on the role of T cells cytokines, including interleukin-13, in pathophysiology of nephrotic syndrome and steroid response. This study was a cross-sectional study conducted at Children’s Medical Center Hospital in order to explore the relationship between urinary IL-13 levels and responsiveness to corticosteroid treatment. All children (1 to 15 years) referred from January 2021 to January 2022 diagnosed with nephrotic syndrome were included. Urine samples were collected during the initial phase or relapse of nephrotic syndrome, before the initiation of steroid or alternative treatments. Interleukin-13 levels in the urine were measured using the ELISA method. In this study, 83 cases of nephrotic syndrome were enrolled, of whom 30 (36.1%) were girls and 53 (63.9%) were boys. Out of the 83 cases, 63 (75.9%) were identified as SSNS and 20 (24.1%) as SRNS. There was no significant difference between the urinary interleukin-13 levels between SSNS and SRNS groups (P-value: 0.84). Sex (P-value: 0.598) and age (P-value: 0.704) also had no association with interleukin-13 levels. Further studies in larger population are recommended to better assess the potential of this biomarker to predict response to treatment. .https://doi.org/10.1038/s41598-025-86488-9Nephrotic syndromeSteroidsNephrotic syndromeIdiopathicSteroid-resistantChild |
| spellingShingle | Behnam Ermian Noosha Samieefar Aida Vahidi Daryoush Fahimi Niloufar Peirovi Mohamed Husein Aldokhi Behnaz Bazargani Arash Abbasi Fahimeh Askarian Mastaneh Moghtaderi Urinary interleukin 13 level in steroid sensitive and resistant nephrotic syndrome: a cross-sectional single center study Scientific Reports Nephrotic syndrome Steroids Nephrotic syndrome Idiopathic Steroid-resistant Child |
| title | Urinary interleukin 13 level in steroid sensitive and resistant nephrotic syndrome: a cross-sectional single center study |
| title_full | Urinary interleukin 13 level in steroid sensitive and resistant nephrotic syndrome: a cross-sectional single center study |
| title_fullStr | Urinary interleukin 13 level in steroid sensitive and resistant nephrotic syndrome: a cross-sectional single center study |
| title_full_unstemmed | Urinary interleukin 13 level in steroid sensitive and resistant nephrotic syndrome: a cross-sectional single center study |
| title_short | Urinary interleukin 13 level in steroid sensitive and resistant nephrotic syndrome: a cross-sectional single center study |
| title_sort | urinary interleukin 13 level in steroid sensitive and resistant nephrotic syndrome a cross sectional single center study |
| topic | Nephrotic syndrome Steroids Nephrotic syndrome Idiopathic Steroid-resistant Child |
| url | https://doi.org/10.1038/s41598-025-86488-9 |
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