VITAMIN D DEFICIENCY DID NOT AUGMENT THE PROGRESSION OF HIGH-FRUCTOSE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS
Objective: Vitamin D has antioxidant, anti-inflammatory and antiglycation activities, and hepatoprotective potential. There is a relationship between vitamin D deficiency (VDD) and the severity of liver disorders. VDD has been proposed to contribute to the progression of nonalcoholic fatty liver dis...
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Istanbul University Press
2021-07-01
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| Series: | İstanbul Tıp Fakültesi Dergisi |
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| Online Access: | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/F055F7C0382D44D6BC94CA5DB57CB2EB |
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| author | İlknur Bingül Canan Küçükgergin Abdurrahman Fatih Aydın Asiye Işın Doğan Ekici Semra Doğru Abbasoğlu Mehmet Müjdat Uysal |
| author_facet | İlknur Bingül Canan Küçükgergin Abdurrahman Fatih Aydın Asiye Işın Doğan Ekici Semra Doğru Abbasoğlu Mehmet Müjdat Uysal |
| author_sort | İlknur Bingül |
| collection | DOAJ |
| description | Objective: Vitamin D has antioxidant, anti-inflammatory and antiglycation activities, and hepatoprotective potential. There is a relationship between vitamin D deficiency (VDD) and the severity of liver disorders. VDD has been proposed to contribute to the progression of nonalcoholic fatty liver disease (NAFLD). However, experimental results are not clear. Therefore, in this study, the effects of a VDD diet on high fructose (HFr) drinking-induced NAFLD was evaluated. Material and Method: Male Wistar rats were divided into four groups as control, HFr, VDD+HFr, and VDD. Control and HFr groups were fed a control diet, and other groups with a VDD-diet for 12 weeks. HFr (30%; w/v; in drinking water) was given in the last 8 weeks. Insulin resistance (IR), serum lipids, hepatic triglyceride, lipid peroxide, protein carbonyl, advanced glycation end products (AGEs) and inflammation (TNF-α and myeloperoxidase) parameters, and histopathological changes were investigated. Results: Increases in serum transaminases, hypertriglyceridemia, and IR were observed in HFr and VDD+HFr groups. Increased liver triglyceride, lipid and protein oxidation products, protein glycation and inflammation markers as well as microvesicular hepatic steatosis and hepatocyte ballooning were observed in both groups. Although IR and hepatic inflammation markers were higher in the VDD+HFr group, serum transaminases, hepatic triglyceride, lipid and protein oxidation products, and glycation indicators in the liver did not alter between the two groups. However, Nrf2 mRNA expression and superoxide dismutase andglutathione peroxidase mRNA expression and activities were significantly higher in the VDD+HFr group. Conclusion: Our results show that VDD did not augmented HFr-induced hepatotoxicity and glycooxidative stress in the liver of rats. |
| format | Article |
| id | doaj-art-d7b91ca2338745f6b65250e2ab1a010a |
| institution | OA Journals |
| issn | 1305-6441 |
| language | English |
| publishDate | 2021-07-01 |
| publisher | Istanbul University Press |
| record_format | Article |
| series | İstanbul Tıp Fakültesi Dergisi |
| spelling | doaj-art-d7b91ca2338745f6b65250e2ab1a010a2025-08-20T02:15:19ZengIstanbul University Pressİstanbul Tıp Fakültesi Dergisi1305-64412021-07-0184336036810.26650/IUITFD.2021.849531123456VITAMIN D DEFICIENCY DID NOT AUGMENT THE PROGRESSION OF HIGH-FRUCTOSE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATSİlknur Bingül0https://orcid.org/0000-0002-6432-3541Canan Küçükgergin1https://orcid.org/0000-0002-1797-5889Abdurrahman Fatih Aydın2https://orcid.org/0000-0002-2595-0833Asiye Işın Doğan Ekici3https://orcid.org/0000-0003-4062-9519Semra Doğru Abbasoğlu4https://orcid.org/0000-0003-3467-9763Mehmet Müjdat Uysal5https://orcid.org/0000-0002-8802-8766İstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeAcıbadem Mehmet Ali Aydınlar Üniversitesi, Istanbul, Turkiyeİstanbul Üniversitesi, İstanbul, Türkiyeİstanbul Üniversitesi, İstanbul, TürkiyeObjective: Vitamin D has antioxidant, anti-inflammatory and antiglycation activities, and hepatoprotective potential. There is a relationship between vitamin D deficiency (VDD) and the severity of liver disorders. VDD has been proposed to contribute to the progression of nonalcoholic fatty liver disease (NAFLD). However, experimental results are not clear. Therefore, in this study, the effects of a VDD diet on high fructose (HFr) drinking-induced NAFLD was evaluated. Material and Method: Male Wistar rats were divided into four groups as control, HFr, VDD+HFr, and VDD. Control and HFr groups were fed a control diet, and other groups with a VDD-diet for 12 weeks. HFr (30%; w/v; in drinking water) was given in the last 8 weeks. Insulin resistance (IR), serum lipids, hepatic triglyceride, lipid peroxide, protein carbonyl, advanced glycation end products (AGEs) and inflammation (TNF-α and myeloperoxidase) parameters, and histopathological changes were investigated. Results: Increases in serum transaminases, hypertriglyceridemia, and IR were observed in HFr and VDD+HFr groups. Increased liver triglyceride, lipid and protein oxidation products, protein glycation and inflammation markers as well as microvesicular hepatic steatosis and hepatocyte ballooning were observed in both groups. Although IR and hepatic inflammation markers were higher in the VDD+HFr group, serum transaminases, hepatic triglyceride, lipid and protein oxidation products, and glycation indicators in the liver did not alter between the two groups. However, Nrf2 mRNA expression and superoxide dismutase andglutathione peroxidase mRNA expression and activities were significantly higher in the VDD+HFr group. Conclusion: Our results show that VDD did not augmented HFr-induced hepatotoxicity and glycooxidative stress in the liver of rats.https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/F055F7C0382D44D6BC94CA5DB57CB2EBvitamin d deficiencyhigh fructose dietnonalcoholic liver diseaseglycooxidative stressantioxidantinflammation |
| spellingShingle | İlknur Bingül Canan Küçükgergin Abdurrahman Fatih Aydın Asiye Işın Doğan Ekici Semra Doğru Abbasoğlu Mehmet Müjdat Uysal VITAMIN D DEFICIENCY DID NOT AUGMENT THE PROGRESSION OF HIGH-FRUCTOSE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS İstanbul Tıp Fakültesi Dergisi vitamin d deficiency high fructose diet nonalcoholic liver disease glycooxidative stress antioxidant inflammation |
| title | VITAMIN D DEFICIENCY DID NOT AUGMENT THE PROGRESSION OF HIGH-FRUCTOSE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS |
| title_full | VITAMIN D DEFICIENCY DID NOT AUGMENT THE PROGRESSION OF HIGH-FRUCTOSE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS |
| title_fullStr | VITAMIN D DEFICIENCY DID NOT AUGMENT THE PROGRESSION OF HIGH-FRUCTOSE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS |
| title_full_unstemmed | VITAMIN D DEFICIENCY DID NOT AUGMENT THE PROGRESSION OF HIGH-FRUCTOSE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS |
| title_short | VITAMIN D DEFICIENCY DID NOT AUGMENT THE PROGRESSION OF HIGH-FRUCTOSE-INDUCED NONALCOHOLIC FATTY LIVER DISEASE IN RATS |
| title_sort | vitamin d deficiency did not augment the progression of high fructose induced nonalcoholic fatty liver disease in rats |
| topic | vitamin d deficiency high fructose diet nonalcoholic liver disease glycooxidative stress antioxidant inflammation |
| url | https://cdn.istanbul.edu.tr/file/JTA6CLJ8T5/F055F7C0382D44D6BC94CA5DB57CB2EB |
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