Integrated single-cell and bulk RNA dequencing to identify and validate prognostic genes related to T Cell senescence in acute myeloid leukemia

Integrated single-cell and bulk RNA dequencing to identify and validate prognostic genes related to T Cell senescence in acute myeloid leukemia

BackgroundT-cell suppression in patients with Acute myeloid leukemia (AML) limits tumor cell clearance. This study aimed to explore the role of T-cell senescence-related genes in AML progression using single-cell RNA sequencing (scRNA-seq), bulk RNA sequencing (RNA-seq), and survival data of patient...

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Bibliographic Details
Main Authors: Mengyao Sha, Jun Chen, Haifeng Hou, Huaihui Dou, Yan Zhang
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Bioinformatics
Subjects:
acute myeloid leukemia
T cell
cell senescence
single-cell RNA sequencing
prognostic risk model
Online Access:https://www.frontiersin.org/articles/10.3389/fbinf.2025.1606284/full
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