Synthesis, Characterization, and Preliminary Evaluation of Biological Activity of 6-Mercaptopurine Heterocyclic Derivatives
Bacterial infections are ongoing challenging due to resistance developed by infectious bacteria. So that many researches targeting designing new antibacterials are published annually. Heterocycles are important field in organic synthesis due to their biological activities. Because of their importan...
Saved in:
| Main Authors: | , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
College of Pharmacy University of Baghdad
2025-06-01
|
| Series: | Iraqi Journal of Pharmaceutical Sciences |
| Subjects: | |
| Online Access: | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3210 |
| Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
| _version_ | 1849430996663926784 |
|---|---|
| author | Noor S. Hashim Muthana S Farhan |
| author_facet | Noor S. Hashim Muthana S Farhan |
| author_sort | Noor S. Hashim |
| collection | DOAJ |
| description |
Bacterial infections are ongoing challenging due to resistance developed by infectious bacteria. So that many researches targeting designing new antibacterials are published annually. Heterocycles are important field in organic synthesis due to their biological activities. Because of their important and considerable pharmacological activities; 1,3-benzothiazole derivatives had received special attention. The purines nucleus are present in several compounds that possess a wide range of biological activities such as antiviral, antifungal, antitumor and antibacterial activities. Hybridization-combing two pharmacophores to form one molecule-is usual method in designing new drugs. The new derivatives of 6-mercaptopurine with 1,3-benzothiazole-2-amine were synthesized and characterized by TLC and spectroscopically by ATR-FTIR and 1HNMR and evaluated for their antibacterial activities. Disk diffusion method was used to evaluate the antibacterial activities of the new compounds.
|
| format | Article |
| id | doaj-art-d7b2618e12d042e1ad342d5d64bf02d3 |
| institution | Kabale University |
| issn | 1683-3597 2521-3512 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | College of Pharmacy University of Baghdad |
| record_format | Article |
| series | Iraqi Journal of Pharmaceutical Sciences |
| spelling | doaj-art-d7b2618e12d042e1ad342d5d64bf02d32025-08-20T03:27:47ZengCollege of Pharmacy University of BaghdadIraqi Journal of Pharmaceutical Sciences1683-35972521-35122025-06-0134210.31351/vol34iss2pp197-205Synthesis, Characterization, and Preliminary Evaluation of Biological Activity of 6-Mercaptopurine Heterocyclic DerivativesNoor S. Hashim0Muthana S Farhan1Ministry of Health, Department of Al-Rusafa Health, Al-Rusafa, Baghdad, IraqDepartment of Pharmaceutical Chemistry, College of Pharmacy, University of Baghdad, Baghdad, Iraq. Bacterial infections are ongoing challenging due to resistance developed by infectious bacteria. So that many researches targeting designing new antibacterials are published annually. Heterocycles are important field in organic synthesis due to their biological activities. Because of their important and considerable pharmacological activities; 1,3-benzothiazole derivatives had received special attention. The purines nucleus are present in several compounds that possess a wide range of biological activities such as antiviral, antifungal, antitumor and antibacterial activities. Hybridization-combing two pharmacophores to form one molecule-is usual method in designing new drugs. The new derivatives of 6-mercaptopurine with 1,3-benzothiazole-2-amine were synthesized and characterized by TLC and spectroscopically by ATR-FTIR and 1HNMR and evaluated for their antibacterial activities. Disk diffusion method was used to evaluate the antibacterial activities of the new compounds. https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3210Bacterial infections Heterocycles BenzothiazolesPurines Hybridization |
| spellingShingle | Noor S. Hashim Muthana S Farhan Synthesis, Characterization, and Preliminary Evaluation of Biological Activity of 6-Mercaptopurine Heterocyclic Derivatives Iraqi Journal of Pharmaceutical Sciences Bacterial infections Heterocycles Benzothiazoles Purines Hybridization |
| title | Synthesis, Characterization, and Preliminary Evaluation of Biological Activity of 6-Mercaptopurine Heterocyclic Derivatives |
| title_full | Synthesis, Characterization, and Preliminary Evaluation of Biological Activity of 6-Mercaptopurine Heterocyclic Derivatives |
| title_fullStr | Synthesis, Characterization, and Preliminary Evaluation of Biological Activity of 6-Mercaptopurine Heterocyclic Derivatives |
| title_full_unstemmed | Synthesis, Characterization, and Preliminary Evaluation of Biological Activity of 6-Mercaptopurine Heterocyclic Derivatives |
| title_short | Synthesis, Characterization, and Preliminary Evaluation of Biological Activity of 6-Mercaptopurine Heterocyclic Derivatives |
| title_sort | synthesis characterization and preliminary evaluation of biological activity of 6 mercaptopurine heterocyclic derivatives |
| topic | Bacterial infections Heterocycles Benzothiazoles Purines Hybridization |
| url | https://bijps.uobaghdad.edu.iq/index.php/bijps/article/view/3210 |
| work_keys_str_mv | AT noorshashim synthesischaracterizationandpreliminaryevaluationofbiologicalactivityof6mercaptopurineheterocyclicderivatives AT muthanasfarhan synthesischaracterizationandpreliminaryevaluationofbiologicalactivityof6mercaptopurineheterocyclicderivatives |