Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs

Toll-like receptor activation induces airway obstruction and hyperresponsiveness in guinea pigs

Abstract Background Microbial infections, particularly those caused by rhinovirus (RV) and respiratory syncytial virus (RSV), are major triggers for asthma exacerbations. These viruses activate toll-like receptors (TLRs), initiating an innate immune response. To better understand microbial-induced a...

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Bibliographic Details
Main Authors: Yujiao Xiang, Jielu Liu, Mu Nie, Gunnar Nilsson, Jesper Säfholm, Mikael Adner
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Respiratory Research
Subjects:
Respiratory infections
Poly (I:C)
Lipopolysaccharide (LPS)
Imiquimod
Inflammation
Mast cell
Online Access:https://doi.org/10.1186/s12931-024-03050-3
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