PEDV infection downregulates goblet cell differentiation through activating the Notch pathway

PEDV infection downregulates goblet cell differentiation through activating the Notch pathway

Abstract Porcine epidemic diarrhoea virus (PEDV) is the most widespread porcine coronavirus worldwide, causing high mortality and a high incidence rate among piglets. The molecular mechanisms by which PEDV regulates epithelial cell function and differentiation, as well as its disruption of the intes...

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Main Authors: Yi Wang, Shanshan Yang, Yongxiang Zhao, Shuo Tian, Qiuxia Cao, Xinmei Geng, Mengdi Yang, Xu Song, Hongqi Shang, Shiyu Liu, Rongli Guo, Yunchuan Li, Min Sun, Mi Hu, Baochao Fan, Bin Li
Format: Article
Language:English
Published: BMC 2025-08-01
Series:Veterinary Research
Subjects:
PEDV
Notch signalling pathway
goblet cells
ORF3
intestinal organoids
Online Access:https://doi.org/10.1186/s13567-025-01599-5
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