Coronary microvascular dysfunction: a review of its association with extracardiac organ pathologies
Coronary microvascular dysfunction (CMD) is a high-risk factor for numerous cardiovascular events, and there is an increasing focus on the diagnosis and treatment of CMD itself or its association with cardiovascular diseases. However, some evidences suggest potential associations between CMD and mul...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-08-01
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| Series: | Frontiers in Cardiovascular Medicine |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1616332/full |
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| author | Yuting Duan Yuting Duan Jia Liu Jia Liu Shan Wang Shan Wang Tongxiao Luan Tongxiao Luan Jing Zhou Ziwei Cui Ziwei Cui Aohua Wang Aohua Wang Mengru Xu Mengru Xu Song Hu Yongjun Mao |
| author_facet | Yuting Duan Yuting Duan Jia Liu Jia Liu Shan Wang Shan Wang Tongxiao Luan Tongxiao Luan Jing Zhou Ziwei Cui Ziwei Cui Aohua Wang Aohua Wang Mengru Xu Mengru Xu Song Hu Yongjun Mao |
| author_sort | Yuting Duan |
| collection | DOAJ |
| description | Coronary microvascular dysfunction (CMD) is a high-risk factor for numerous cardiovascular events, and there is an increasing focus on the diagnosis and treatment of CMD itself or its association with cardiovascular diseases. However, some evidences suggest potential associations between CMD and multiple extracardiac pathologies, such as cerebrovascular, renal, pulmonary, retinal, hepatic, immune system diseases, and cancer. A shared pathological mechanism may underlie these connections, yet the relationship between CMD and other organs and systemic diseases remains unclear. Therefore, this review comprehensively assesses the current evidence base for the interplay between CMD and a range of systemic diseases, highlighting the need for a more integrated diagnostic and therapeutic approach. |
| format | Article |
| id | doaj-art-d7a638c112d348adafc0b5f071b98fc5 |
| institution | Kabale University |
| issn | 2297-055X |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cardiovascular Medicine |
| spelling | doaj-art-d7a638c112d348adafc0b5f071b98fc52025-08-20T04:00:50ZengFrontiers Media S.A.Frontiers in Cardiovascular Medicine2297-055X2025-08-011210.3389/fcvm.2025.16163321616332Coronary microvascular dysfunction: a review of its association with extracardiac organ pathologiesYuting Duan0Yuting Duan1Jia Liu2Jia Liu3Shan Wang4Shan Wang5Tongxiao Luan6Tongxiao Luan7Jing Zhou8Ziwei Cui9Ziwei Cui10Aohua Wang11Aohua Wang12Mengru Xu13Mengru Xu14Song Hu15Yongjun Mao16Department of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, ChinaQingdao University, Laoshan District, Qingdao, Shandong, ChinaDepartment of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, ChinaQingdao University, Laoshan District, Qingdao, Shandong, ChinaDepartment of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, ChinaQingdao University, Laoshan District, Qingdao, Shandong, ChinaDepartment of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, ChinaQingdao University, Laoshan District, Qingdao, Shandong, ChinaDepartment of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, ChinaDepartment of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, ChinaQingdao University, Laoshan District, Qingdao, Shandong, ChinaDepartment of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, ChinaQingdao University, Laoshan District, Qingdao, Shandong, ChinaDepartment of Geriatric Medicine, The Affiliated Hospital of Qingdao University, Qingdao, ChinaQingdao University, Laoshan District, Qingdao, Shandong, ChinaQingdao University, Laoshan District, Qingdao, Shandong, ChinaQingdao University, Laoshan District, Qingdao, Shandong, ChinaCoronary microvascular dysfunction (CMD) is a high-risk factor for numerous cardiovascular events, and there is an increasing focus on the diagnosis and treatment of CMD itself or its association with cardiovascular diseases. However, some evidences suggest potential associations between CMD and multiple extracardiac pathologies, such as cerebrovascular, renal, pulmonary, retinal, hepatic, immune system diseases, and cancer. A shared pathological mechanism may underlie these connections, yet the relationship between CMD and other organs and systemic diseases remains unclear. Therefore, this review comprehensively assesses the current evidence base for the interplay between CMD and a range of systemic diseases, highlighting the need for a more integrated diagnostic and therapeutic approach.https://www.frontiersin.org/articles/10.3389/fcvm.2025.1616332/fullcoronary microvascular dysfunctionmicrovascular dysfunctionnon-obstructive coronary artery diseasecardiovascular diseasesmyocardial ischemia |
| spellingShingle | Yuting Duan Yuting Duan Jia Liu Jia Liu Shan Wang Shan Wang Tongxiao Luan Tongxiao Luan Jing Zhou Ziwei Cui Ziwei Cui Aohua Wang Aohua Wang Mengru Xu Mengru Xu Song Hu Yongjun Mao Coronary microvascular dysfunction: a review of its association with extracardiac organ pathologies Frontiers in Cardiovascular Medicine coronary microvascular dysfunction microvascular dysfunction non-obstructive coronary artery disease cardiovascular diseases myocardial ischemia |
| title | Coronary microvascular dysfunction: a review of its association with extracardiac organ pathologies |
| title_full | Coronary microvascular dysfunction: a review of its association with extracardiac organ pathologies |
| title_fullStr | Coronary microvascular dysfunction: a review of its association with extracardiac organ pathologies |
| title_full_unstemmed | Coronary microvascular dysfunction: a review of its association with extracardiac organ pathologies |
| title_short | Coronary microvascular dysfunction: a review of its association with extracardiac organ pathologies |
| title_sort | coronary microvascular dysfunction a review of its association with extracardiac organ pathologies |
| topic | coronary microvascular dysfunction microvascular dysfunction non-obstructive coronary artery disease cardiovascular diseases myocardial ischemia |
| url | https://www.frontiersin.org/articles/10.3389/fcvm.2025.1616332/full |
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