Somatic NAP1L1 p.D349E promotes cardiac hypertrophy through cGAS-STING-IFN signaling

Somatic NAP1L1 p.D349E promotes cardiac hypertrophy through cGAS-STING-IFN signaling

Abstract Hypertrophic cardiomyopathy (HCM) is the most common inherited heart disease, often caused by sarcomere gene mutations, though many sporadic cases remain genetically unexplained. Here we show that the somatic variant NAP1L1 p.D349E was involved in cardiac hypertrophy in sporadic HCM patient...

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Main Authors: Cheng Lv, Xiayidan Alimu, Xiao Xiao, Fei Wang, Jizheng Wang, Shuiyun Wang, Guixin Wu, Yu Zhang, Yue Wu, Houzao Chen, Rutai Hui, Lei Song, Yibo Wang
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58453-7
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