Role of right dorsolateral prefrontal cortex–left primary motor cortex interaction in motor inhibition in Parkinson’s disease
BackgroundImpaired motor inhibition in Parkinson’s disease (PD) is associated with functional alterations in the frontal-basal ganglia (BG) neural circuits. The right dorsolateral prefrontal cortex (DLPFC), pre-supplementary motor area (pre-SMA), and primary motor cortex (M1) play key roles in regul...
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Frontiers Media S.A.
2025-03-01
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| Series: | Frontiers in Aging Neuroscience |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1524755/full |
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| author | Zhen Wang Zhen Wang Jianing Wei Yuyu Song Yuting Li Yuting Li Yin Wu Robert Chen Robert Chen Zhen Wang Jian Zhang Xiaoyin Tan Ke Liu |
| author_facet | Zhen Wang Zhen Wang Jianing Wei Yuyu Song Yuting Li Yuting Li Yin Wu Robert Chen Robert Chen Zhen Wang Jian Zhang Xiaoyin Tan Ke Liu |
| author_sort | Zhen Wang |
| collection | DOAJ |
| description | BackgroundImpaired motor inhibition in Parkinson’s disease (PD) is associated with functional alterations in the frontal-basal ganglia (BG) neural circuits. The right dorsolateral prefrontal cortex (DLPFC), pre-supplementary motor area (pre-SMA), and primary motor cortex (M1) play key roles in regulating this inhibition. However, the changes in interhemispheric interactions during motor inhibition in PD have not been clearly defined.MethodsWe used dual-site paired-pulse transcranial magnetic stimulation (ppTMS) to examine the interactions between the right DLPFC and pre-SMA and the left M1 in 30 patients with early-stage PD and 30 age-matched healthy controls (HC) during both resting and active conditions, specifically while performing a stop-signal task (SST).ResultsStop-signal reaction times (SSRT) were significantly longer in PD patients compared to HC. The right DLPFC–left M1 interaction, at both short- and long-latency intervals, showed enhanced inhibition in PD following the stop-signal. In PD patients, SSRT was correlated with the inhibition of the right DLPFC–left M1 interaction, with stronger inhibition associated with shorter SSRT.ConclusionThe deficit in reactive inhibition observed in PD is linked to an abnormal modulation of the right DLPFC–left M1 interaction during the stopping process. |
| format | Article |
| id | doaj-art-d79ee7d73f6f453c8ec022a6f01b713d |
| institution | OA Journals |
| issn | 1663-4365 |
| language | English |
| publishDate | 2025-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Aging Neuroscience |
| spelling | doaj-art-d79ee7d73f6f453c8ec022a6f01b713d2025-08-20T02:02:25ZengFrontiers Media S.A.Frontiers in Aging Neuroscience1663-43652025-03-011710.3389/fnagi.2025.15247551524755Role of right dorsolateral prefrontal cortex–left primary motor cortex interaction in motor inhibition in Parkinson’s diseaseZhen Wang0Zhen Wang1Jianing Wei2Yuyu Song3Yuting Li4Yuting Li5Yin Wu6Robert Chen7Robert Chen8Zhen Wang9Jian Zhang10Xiaoyin Tan11Ke Liu12School of Sport and Health Science, Xi'an Physical Education University, Xi'an, ChinaSchool of Psychology, Shanghai University of Sport, Shanghai, ChinaHenan University of Science and Technology Sports Institute, Luoyang, ChinaSchool of Psychology, Shanghai University of Sport, Shanghai, ChinaSchool of Psychology, Shanghai University of Sport, Shanghai, ChinaDepartment of Chinese Medicine Nursing, School of Nursing, Anhui University of Chinese Medicine, Hefei, ChinaSchool of Economics and Management, Shanghai University of Sport, Shanghai, ChinaKrembil Research Institute, University Health Network, Toronto, ON, CanadaDivision of Neurology, Department of Medicine, University of Toronto, Toronto, ON, CanadaSchool of Martial Arts, Shanghai University of Sport, Shanghai, ChinaSchool of Psychology, Shanghai University of Sport, Shanghai, ChinaFaculty of Health Sciences and Sports, Macao Polytechnic University, Macau, Macao SAR, China0Shanghai Punan Hospital of Pudong New District, Shanghai, ChinaBackgroundImpaired motor inhibition in Parkinson’s disease (PD) is associated with functional alterations in the frontal-basal ganglia (BG) neural circuits. The right dorsolateral prefrontal cortex (DLPFC), pre-supplementary motor area (pre-SMA), and primary motor cortex (M1) play key roles in regulating this inhibition. However, the changes in interhemispheric interactions during motor inhibition in PD have not been clearly defined.MethodsWe used dual-site paired-pulse transcranial magnetic stimulation (ppTMS) to examine the interactions between the right DLPFC and pre-SMA and the left M1 in 30 patients with early-stage PD and 30 age-matched healthy controls (HC) during both resting and active conditions, specifically while performing a stop-signal task (SST).ResultsStop-signal reaction times (SSRT) were significantly longer in PD patients compared to HC. The right DLPFC–left M1 interaction, at both short- and long-latency intervals, showed enhanced inhibition in PD following the stop-signal. In PD patients, SSRT was correlated with the inhibition of the right DLPFC–left M1 interaction, with stronger inhibition associated with shorter SSRT.ConclusionThe deficit in reactive inhibition observed in PD is linked to an abnormal modulation of the right DLPFC–left M1 interaction during the stopping process.https://www.frontiersin.org/articles/10.3389/fnagi.2025.1524755/fullParkinson’s diseasemotor inhibitioninterhemispheric interactiondorsolateral prefrontal cortexpre-supplementary motor area |
| spellingShingle | Zhen Wang Zhen Wang Jianing Wei Yuyu Song Yuting Li Yuting Li Yin Wu Robert Chen Robert Chen Zhen Wang Jian Zhang Xiaoyin Tan Ke Liu Role of right dorsolateral prefrontal cortex–left primary motor cortex interaction in motor inhibition in Parkinson’s disease Frontiers in Aging Neuroscience Parkinson’s disease motor inhibition interhemispheric interaction dorsolateral prefrontal cortex pre-supplementary motor area |
| title | Role of right dorsolateral prefrontal cortex–left primary motor cortex interaction in motor inhibition in Parkinson’s disease |
| title_full | Role of right dorsolateral prefrontal cortex–left primary motor cortex interaction in motor inhibition in Parkinson’s disease |
| title_fullStr | Role of right dorsolateral prefrontal cortex–left primary motor cortex interaction in motor inhibition in Parkinson’s disease |
| title_full_unstemmed | Role of right dorsolateral prefrontal cortex–left primary motor cortex interaction in motor inhibition in Parkinson’s disease |
| title_short | Role of right dorsolateral prefrontal cortex–left primary motor cortex interaction in motor inhibition in Parkinson’s disease |
| title_sort | role of right dorsolateral prefrontal cortex left primary motor cortex interaction in motor inhibition in parkinson s disease |
| topic | Parkinson’s disease motor inhibition interhemispheric interaction dorsolateral prefrontal cortex pre-supplementary motor area |
| url | https://www.frontiersin.org/articles/10.3389/fnagi.2025.1524755/full |
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