Perioperative Animal Care for Xenotransplantation from Genetically Edited Pigs to Monkeys
Objective To discuss the perioperative care and wound protection of xenotransplantation from genetically edited pigs to monkeys, with the goal of improving the success rate of such experimental procedures. Methods From October 2022 to October 2023, perioperative care and wound protection were perfor...
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| Format: | Article |
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Editorial Office of Laboratory Animal and Comparative Medicine
2024-10-01
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| Series: | Shiyan dongwu yu bijiao yixue |
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| Online Access: | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2024.043 |
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| author | ZHU Chan ZHANG Dongliang ZHAO Deli SHI Xueqin QIAN Lei ZHANG Xuan JIN Yan DUAN Wei QI Ruocheng LIU Chaohua YANG Xuekang HAN Juntao PAN Dengke |
| author_facet | ZHU Chan ZHANG Dongliang ZHAO Deli SHI Xueqin QIAN Lei ZHANG Xuan JIN Yan DUAN Wei QI Ruocheng LIU Chaohua YANG Xuekang HAN Juntao PAN Dengke |
| author_sort | ZHU Chan |
| collection | DOAJ |
| description | Objective To discuss the perioperative care and wound protection of xenotransplantation from genetically edited pigs to monkeys, with the goal of improving the success rate of such experimental procedures. Methods From October 2022 to October 2023, perioperative care and wound protection were performed on 7 recipient rhesus monkeys undergoing xenotransplantation of genetically edited pig tissues and organs. Customized wound protective garments were designed based on monkeys' size and surgical area to protect the wounds, alongside meticulous perioperative care. This included preoperative preparation and medication, intraoperative monitoring of physiological indicators and anesthesia management, and postoperative care comprising wound protection, observation and monitoring, and nutritional support. Results All seven monkeys successfully underwent xenotransplantation. With the aid of protective garments and detailed care, all surgical wounds healed by first intention, and postoperative recovery was satisfactory. Conclusion Proper care and wound protection during xenotransplantation from genetically edited pigs to monkeys not only promote wound healing, but also alleviate pain and harm to animals. This has significant implications for advancing experimental research in pig-monkey xenotransplantation and enhancing animal welfare. |
| format | Article |
| id | doaj-art-d79d581674e740c9b1794639b9c0ee34 |
| institution | Kabale University |
| issn | 1674-5817 |
| language | zho |
| publishDate | 2024-10-01 |
| publisher | Editorial Office of Laboratory Animal and Comparative Medicine |
| record_format | Article |
| series | Shiyan dongwu yu bijiao yixue |
| spelling | doaj-art-d79d581674e740c9b1794639b9c0ee342025-01-06T05:07:29ZzhoEditorial Office of Laboratory Animal and Comparative MedicineShiyan dongwu yu bijiao yixue1674-58172024-10-0144549550110.12300/j.issn.1674-5817.2024.0431674-5817（2024）05-0495-07Perioperative Animal Care for Xenotransplantation from Genetically Edited Pigs to MonkeysZHU Chan0ZHANG Dongliang1ZHAO Deli2SHI Xueqin3QIAN Lei4ZHANG Xuan5JIN Yan6DUAN Wei7QI Ruocheng8LIU Chaohua9YANG Xuekang10HAN Juntao11PAN Dengke12Department of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital, Air Force Medical University, Xi'an710032, ChinaDepartment of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital, Air Force Medical University, Xi'an710032, ChinaDepartment of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital, Air Force Medical University, Xi'an710032, ChinaDepartment of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital, Air Force Medical University, Xi'an710032, ChinaLaboratory Animal Centre, Air Force Medical University, Xi'an710032, ChinaDepartment of Hepatobiliary Surgery, the First Affiliated Hospital, Air Force Medical University, Xi'an710032, ChinaDepartment of Cardiac Surgery, the First Affiliated Hospital, Air Force Medical University, Xi'an710032, ChinaDepartment of Orthopedics, the First Affiliated Hospital, Air Force Medical University, Xi'an710032, ChinaDepartment of Urinary Surgery, the First Affiliated Hospital, Air Force Medical University, Xi'an710032, ChinaDepartment of Plastic Surgery, the First Affiliated Hospital, Air Force Medical University, Xi'an710032, ChinaDepartment of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital, Air Force Medical University, Xi'an710032, ChinaDepartment of Burns and Cutaneous Surgery, Burn Center of PLA, the First Affiliated Hospital, Air Force Medical University, Xi'an710032, ChinaChengdu Clonorgan Biotechnology Co., Ltd., Chengdu610095 ,ChinaObjective To discuss the perioperative care and wound protection of xenotransplantation from genetically edited pigs to monkeys, with the goal of improving the success rate of such experimental procedures. Methods From October 2022 to October 2023, perioperative care and wound protection were performed on 7 recipient rhesus monkeys undergoing xenotransplantation of genetically edited pig tissues and organs. Customized wound protective garments were designed based on monkeys' size and surgical area to protect the wounds, alongside meticulous perioperative care. This included preoperative preparation and medication, intraoperative monitoring of physiological indicators and anesthesia management, and postoperative care comprising wound protection, observation and monitoring, and nutritional support. Results All seven monkeys successfully underwent xenotransplantation. With the aid of protective garments and detailed care, all surgical wounds healed by first intention, and postoperative recovery was satisfactory. Conclusion Proper care and wound protection during xenotransplantation from genetically edited pigs to monkeys not only promote wound healing, but also alleviate pain and harm to animals. This has significant implications for advancing experimental research in pig-monkey xenotransplantation and enhancing animal welfare.https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2024.043genetically edited pigxenotransplantationrhesus monkeycarewound protection devicelaboratory animal welfare |
| spellingShingle | ZHU Chan ZHANG Dongliang ZHAO Deli SHI Xueqin QIAN Lei ZHANG Xuan JIN Yan DUAN Wei QI Ruocheng LIU Chaohua YANG Xuekang HAN Juntao PAN Dengke Perioperative Animal Care for Xenotransplantation from Genetically Edited Pigs to Monkeys Shiyan dongwu yu bijiao yixue genetically edited pig xenotransplantation rhesus monkey care wound protection device laboratory animal welfare |
| title | Perioperative Animal Care for Xenotransplantation from Genetically Edited Pigs to Monkeys |
| title_full | Perioperative Animal Care for Xenotransplantation from Genetically Edited Pigs to Monkeys |
| title_fullStr | Perioperative Animal Care for Xenotransplantation from Genetically Edited Pigs to Monkeys |
| title_full_unstemmed | Perioperative Animal Care for Xenotransplantation from Genetically Edited Pigs to Monkeys |
| title_short | Perioperative Animal Care for Xenotransplantation from Genetically Edited Pigs to Monkeys |
| title_sort | perioperative animal care for xenotransplantation from genetically edited pigs to monkeys |
| topic | genetically edited pig xenotransplantation rhesus monkey care wound protection device laboratory animal welfare |
| url | https://www.slarc.org.cn/dwyx/CN/10.12300/j.issn.1674-5817.2024.043 |
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