Effect of fiber-modified kombucha tea on gut microbiota in healthy population: A randomized controlled trial (RCT)
Background: The development of functional foods with health-promoting properties is a priority in addressing chronic diseases. Studying the effect of these foods on gut microbiota provides critical insights into the interplay between microorganisms, health, and disease. Objective: This study aimed t...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Current Research in Food Science |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2665927125001613 |
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| author | Beatriz Arce-López Guadalupe X. Bazan Susana Molina Maria Carmen Crespo María García-Beccaria Silvia Cruz-Gil Cristina M. Fernández-Díaz Ana Ramírez de Molina Ricardo Ramos-Ruiz Maria Isabel Espinosa-Salinas |
| author_facet | Beatriz Arce-López Guadalupe X. Bazan Susana Molina Maria Carmen Crespo María García-Beccaria Silvia Cruz-Gil Cristina M. Fernández-Díaz Ana Ramírez de Molina Ricardo Ramos-Ruiz Maria Isabel Espinosa-Salinas |
| author_sort | Beatriz Arce-López |
| collection | DOAJ |
| description | Background: The development of functional foods with health-promoting properties is a priority in addressing chronic diseases. Studying the effect of these foods on gut microbiota provides critical insights into the interplay between microorganisms, health, and disease. Objective: This study aimed to evaluate the effects of fiber-enriched kombucha tea on biochemical parameters and gut microbiota composition in a healthy population. Methods: A randomized, double-blind, parallel nutritional intervention trial was conducted with 60 participants (58 completed: 42 women and 16 men; mean ± SD age: 39.79 ± 14.58 years). Participants were randomized into two groups consuming either 250 mL/day of a control beverage (unfermented tea) or the fiber-enriched kombucha tea for six weeks. Lifestyle and biochemical data were collected, and gut microbiota composition and diversity were assessed using 16S rDNA sequencing. Results: Significant biochemical and microbiota-related improvements were observed in the study group compared to the control. The treatment significantly affected triglyceride levels (p-value = 0.031). In particular, the study group exhibited a reduction in triglyceride levels very close to significance (baseline mean ± SEM: 69.59 ± 6.98 mg/dL; post-intervention: 62.80 ± 5.14 mg/dL; p = 0.053), while the control group did not experience a significant variation. Additionally, fiber-enriched kombucha consumption led to a notable increase in Bifidobacterium abundance, recognized for its intestinal health benefits and immunomodulatory effects. A reduction in Ruminococcus torques, linked to inflammatory bowel diseases, was also observed. Conclusions: The studied fiber-enriched kombucha drink demonstrated potential health benefits, including triglyceride modulation and positive alterations in gut microbiota composition. These findings suggest its promise as a functional beverage for improving metabolic and gut health in healthy individuals. However, further randomized controlled trials are warranted to confirm these benefits. This trial was registered at clinicaltrials.gov as NCT06626997. |
| format | Article |
| id | doaj-art-d796ccda2e464e80b25bd6701920956e |
| institution | Kabale University |
| issn | 2665-9271 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
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| series | Current Research in Food Science |
| spelling | doaj-art-d796ccda2e464e80b25bd6701920956e2025-08-20T03:29:15ZengElsevierCurrent Research in Food Science2665-92712025-01-011110113010.1016/j.crfs.2025.101130Effect of fiber-modified kombucha tea on gut microbiota in healthy population: A randomized controlled trial (RCT)Beatriz Arce-López0Guadalupe X. Bazan1Susana Molina2Maria Carmen Crespo3María García-Beccaria4Silvia Cruz-Gil5Cristina M. Fernández-Díaz6Ana Ramírez de Molina7Ricardo Ramos-Ruiz8Maria Isabel Espinosa-Salinas9GENYAL Platform, IMDEA Food, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, SpainGENYAL Platform, IMDEA Food, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, SpainGENYAL Platform, IMDEA Food, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, SpainGENYAL Platform, IMDEA Food, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, SpainGENYAL Platform, IMDEA Food, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, SpainMolecular Oncology Group, IMDEA Food, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, SpainGENYAL Platform, IMDEA Food, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, SpainGENYAL Platform, IMDEA Food, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, Spain; Molecular Oncology Group, IMDEA Food, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, SpainGENYAL Platform, IMDEA Food, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, Spain; Molecular Oncology Group, IMDEA Food, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, SpainGENYAL Platform, IMDEA Food, CEI UAM+CSIC, Carretera de Cantoblanco, 8, 28049, Madrid, Spain; Corresponding author.Background: The development of functional foods with health-promoting properties is a priority in addressing chronic diseases. Studying the effect of these foods on gut microbiota provides critical insights into the interplay between microorganisms, health, and disease. Objective: This study aimed to evaluate the effects of fiber-enriched kombucha tea on biochemical parameters and gut microbiota composition in a healthy population. Methods: A randomized, double-blind, parallel nutritional intervention trial was conducted with 60 participants (58 completed: 42 women and 16 men; mean ± SD age: 39.79 ± 14.58 years). Participants were randomized into two groups consuming either 250 mL/day of a control beverage (unfermented tea) or the fiber-enriched kombucha tea for six weeks. Lifestyle and biochemical data were collected, and gut microbiota composition and diversity were assessed using 16S rDNA sequencing. Results: Significant biochemical and microbiota-related improvements were observed in the study group compared to the control. The treatment significantly affected triglyceride levels (p-value = 0.031). In particular, the study group exhibited a reduction in triglyceride levels very close to significance (baseline mean ± SEM: 69.59 ± 6.98 mg/dL; post-intervention: 62.80 ± 5.14 mg/dL; p = 0.053), while the control group did not experience a significant variation. Additionally, fiber-enriched kombucha consumption led to a notable increase in Bifidobacterium abundance, recognized for its intestinal health benefits and immunomodulatory effects. A reduction in Ruminococcus torques, linked to inflammatory bowel diseases, was also observed. Conclusions: The studied fiber-enriched kombucha drink demonstrated potential health benefits, including triglyceride modulation and positive alterations in gut microbiota composition. These findings suggest its promise as a functional beverage for improving metabolic and gut health in healthy individuals. However, further randomized controlled trials are warranted to confirm these benefits. This trial was registered at clinicaltrials.gov as NCT06626997.http://www.sciencedirect.com/science/article/pii/S2665927125001613FiberKombucha teaGut microbiotaFermented beveragesHuman healthPrebiotics |
| spellingShingle | Beatriz Arce-López Guadalupe X. Bazan Susana Molina Maria Carmen Crespo María García-Beccaria Silvia Cruz-Gil Cristina M. Fernández-Díaz Ana Ramírez de Molina Ricardo Ramos-Ruiz Maria Isabel Espinosa-Salinas Effect of fiber-modified kombucha tea on gut microbiota in healthy population: A randomized controlled trial (RCT) Current Research in Food Science Fiber Kombucha tea Gut microbiota Fermented beverages Human health Prebiotics |
| title | Effect of fiber-modified kombucha tea on gut microbiota in healthy population: A randomized controlled trial (RCT) |
| title_full | Effect of fiber-modified kombucha tea on gut microbiota in healthy population: A randomized controlled trial (RCT) |
| title_fullStr | Effect of fiber-modified kombucha tea on gut microbiota in healthy population: A randomized controlled trial (RCT) |
| title_full_unstemmed | Effect of fiber-modified kombucha tea on gut microbiota in healthy population: A randomized controlled trial (RCT) |
| title_short | Effect of fiber-modified kombucha tea on gut microbiota in healthy population: A randomized controlled trial (RCT) |
| title_sort | effect of fiber modified kombucha tea on gut microbiota in healthy population a randomized controlled trial rct |
| topic | Fiber Kombucha tea Gut microbiota Fermented beverages Human health Prebiotics |
| url | http://www.sciencedirect.com/science/article/pii/S2665927125001613 |
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