An Update of Research Animal Models of Inflammatory Bowel Disease
Inflammatory bowel disease (IBD) is a group of chronic disorders that includes two main disease forms, Crohn’s disease, and ulcerative colitis. The understanding of the intestinal inflammation occurring in IBD has been immeasurably advanced by the development of the now numerous murine models of int...
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| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2021-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2021/7479540 |
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| author | Zineb Baydi Youness Limami Loubna Khalki Nabil Zaid Abdallah Naya El Mostafa Mtairag Mounia Oudghiri Younes Zaid |
| author_facet | Zineb Baydi Youness Limami Loubna Khalki Nabil Zaid Abdallah Naya El Mostafa Mtairag Mounia Oudghiri Younes Zaid |
| author_sort | Zineb Baydi |
| collection | DOAJ |
| description | Inflammatory bowel disease (IBD) is a group of chronic disorders that includes two main disease forms, Crohn’s disease, and ulcerative colitis. The understanding of the intestinal inflammation occurring in IBD has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation. The usefulness of this research tool in IBD arises from a convergence of underlying genetic susceptibility, immune system dysfunction, environmental factors, and shifts in gut microbiota. Due to the multifactorial feature of these diseases, different animal models have been used to investigate the underlying mechanisms and develop potential therapeutic strategies. The results of preclinical efficacy studies often inform the progression of therapeutic strategies. This review describes the distinct feature and limitations of each murine IBD model and discusses the previous and current lessons from the IBD models. |
| format | Article |
| id | doaj-art-d7905cb8562a429faa928aa9f5d06d72 |
| institution | DOAJ |
| issn | 1537-744X |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d7905cb8562a429faa928aa9f5d06d722025-08-20T03:19:49ZengWileyThe Scientific World Journal1537-744X2021-01-01202110.1155/2021/7479540An Update of Research Animal Models of Inflammatory Bowel DiseaseZineb Baydi0Youness Limami1Loubna Khalki2Nabil Zaid3Abdallah Naya4El Mostafa Mtairag5Mounia Oudghiri6Younes Zaid7Immunology and Biodiversity LaboratoryImmunology and Biodiversity LaboratoryMohammed VI University of Health Sciences (UM6SS)Biology DepartmentImmunology and Biodiversity LaboratoryImmunology and Biodiversity LaboratoryImmunology and Biodiversity LaboratoryImmunology and Biodiversity LaboratoryInflammatory bowel disease (IBD) is a group of chronic disorders that includes two main disease forms, Crohn’s disease, and ulcerative colitis. The understanding of the intestinal inflammation occurring in IBD has been immeasurably advanced by the development of the now numerous murine models of intestinal inflammation. The usefulness of this research tool in IBD arises from a convergence of underlying genetic susceptibility, immune system dysfunction, environmental factors, and shifts in gut microbiota. Due to the multifactorial feature of these diseases, different animal models have been used to investigate the underlying mechanisms and develop potential therapeutic strategies. The results of preclinical efficacy studies often inform the progression of therapeutic strategies. This review describes the distinct feature and limitations of each murine IBD model and discusses the previous and current lessons from the IBD models.http://dx.doi.org/10.1155/2021/7479540 |
| spellingShingle | Zineb Baydi Youness Limami Loubna Khalki Nabil Zaid Abdallah Naya El Mostafa Mtairag Mounia Oudghiri Younes Zaid An Update of Research Animal Models of Inflammatory Bowel Disease The Scientific World Journal |
| title | An Update of Research Animal Models of Inflammatory Bowel Disease |
| title_full | An Update of Research Animal Models of Inflammatory Bowel Disease |
| title_fullStr | An Update of Research Animal Models of Inflammatory Bowel Disease |
| title_full_unstemmed | An Update of Research Animal Models of Inflammatory Bowel Disease |
| title_short | An Update of Research Animal Models of Inflammatory Bowel Disease |
| title_sort | update of research animal models of inflammatory bowel disease |
| url | http://dx.doi.org/10.1155/2021/7479540 |
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