Ceftazidime-avibactam susceptibility against Escherichia coli and Klebsiella pneumoniae
Background and Objectives: Carbapenem-resistant Enterobacteriaceae (CRE) infections are extremely difficult to treat and have a high fatality rate. The study's primary goal was to determine the rate of ceftazidime-avibactam susceptibility using disc diffusion and E-Test, as well as to evaluate...
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Tehran University of Medical Sciences
2025-02-01
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| Series: | Iranian Journal of Microbiology |
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| Online Access: | https://ijm.tums.ac.ir/index.php/ijm/article/view/4901 |
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| author | Arun Sachu Alice David |
| author_facet | Arun Sachu Alice David |
| author_sort | Arun Sachu |
| collection | DOAJ |
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Background and Objectives: Carbapenem-resistant Enterobacteriaceae (CRE) infections are extremely difficult to treat and have a high fatality rate. The study's primary goal was to determine the rate of ceftazidime-avibactam susceptibility using disc diffusion and E-Test, as well as to evaluate the agreement between the two methods.
Materials and Methods: A total of 124 multidrug-resistant (including carbapenem) Escherichia coli and Klebisella pneumoniae isolates were included. Kirby Bauer's disc diffusion and E-test were used as the testing methods in this study.
Results: In this study 37.5% and 33.9% of the isolates were susceptible to ceftazidime-avibactam by E test and Disc diffusion respectively. There were five isolates which produced discordant results. Among the 56 isolates there was 91% agreement between the two methods.
Conclusion: Among the discordant isolates the alarming disparity in zone size was a significant concern. Since CRE infections are very common, an economical and practical method for testing ceftazidime-avibactam susceptibility is needed in all the clinical microbiology laboratories as it is a last resort drug.
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| format | Article |
| id | doaj-art-d7856b853e2c41f881f0fdc882b4de3f |
| institution | Kabale University |
| issn | 2008-3289 2008-4447 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Tehran University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Microbiology |
| spelling | doaj-art-d7856b853e2c41f881f0fdc882b4de3f2025-02-09T09:01:35ZengTehran University of Medical SciencesIranian Journal of Microbiology2008-32892008-44472025-02-01171Ceftazidime-avibactam susceptibility against Escherichia coli and Klebsiella pneumoniaeArun Sachu0Alice David1Department of Microbiology, Believers Church Medical College, Thiruvalla, Kerala, IndiaHead of Medical Research, Believers Church Medical College, Thiruvalla, Kerala, India Background and Objectives: Carbapenem-resistant Enterobacteriaceae (CRE) infections are extremely difficult to treat and have a high fatality rate. The study's primary goal was to determine the rate of ceftazidime-avibactam susceptibility using disc diffusion and E-Test, as well as to evaluate the agreement between the two methods. Materials and Methods: A total of 124 multidrug-resistant (including carbapenem) Escherichia coli and Klebisella pneumoniae isolates were included. Kirby Bauer's disc diffusion and E-test were used as the testing methods in this study. Results: In this study 37.5% and 33.9% of the isolates were susceptible to ceftazidime-avibactam by E test and Disc diffusion respectively. There were five isolates which produced discordant results. Among the 56 isolates there was 91% agreement between the two methods. Conclusion: Among the discordant isolates the alarming disparity in zone size was a significant concern. Since CRE infections are very common, an economical and practical method for testing ceftazidime-avibactam susceptibility is needed in all the clinical microbiology laboratories as it is a last resort drug. https://ijm.tums.ac.ir/index.php/ijm/article/view/4901Infection;Resistance;Susceptibility;Enterobacteriaceae;Carbapenem |
| spellingShingle | Arun Sachu Alice David Ceftazidime-avibactam susceptibility against Escherichia coli and Klebsiella pneumoniae Iranian Journal of Microbiology Infection; Resistance; Susceptibility; Enterobacteriaceae; Carbapenem |
| title | Ceftazidime-avibactam susceptibility against Escherichia coli and Klebsiella pneumoniae |
| title_full | Ceftazidime-avibactam susceptibility against Escherichia coli and Klebsiella pneumoniae |
| title_fullStr | Ceftazidime-avibactam susceptibility against Escherichia coli and Klebsiella pneumoniae |
| title_full_unstemmed | Ceftazidime-avibactam susceptibility against Escherichia coli and Klebsiella pneumoniae |
| title_short | Ceftazidime-avibactam susceptibility against Escherichia coli and Klebsiella pneumoniae |
| title_sort | ceftazidime avibactam susceptibility against escherichia coli and klebsiella pneumoniae |
| topic | Infection; Resistance; Susceptibility; Enterobacteriaceae; Carbapenem |
| url | https://ijm.tums.ac.ir/index.php/ijm/article/view/4901 |
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