Evaluation of FeMnN alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm model
IntroductionFlow diverters are specialized stents used to treat intracranial aneurysms. Bioresorbable flow diverters (BRFDs) have been proposed as the next-generation of flow diverter technology. BRFDs aim to occlude and heal the aneurysm before safely dissolving into the body, mitigating complicati...
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Frontiers Media S.A.
2025-02-01
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| Series: | Frontiers in Bioengineering and Biotechnology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1522696/full |
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| author | Alexander A. Oliver Alexander A. Oliver Alexander A. Oliver Cem Bilgin Jonathan Cortese Jonathan Cortese Esref A. Bayraktar Daying Dai Yong Hong Ding Kent D. Carlson Adam J. Griebel Jeremy E. Schaffer Mitchell L. Connon Dan Dragomir-Daescu Dan Dragomir-Daescu Ramanathan Kadirvel Roger J. Guillory David F. Kallmes David F. Kallmes |
| author_facet | Alexander A. Oliver Alexander A. Oliver Alexander A. Oliver Cem Bilgin Jonathan Cortese Jonathan Cortese Esref A. Bayraktar Daying Dai Yong Hong Ding Kent D. Carlson Adam J. Griebel Jeremy E. Schaffer Mitchell L. Connon Dan Dragomir-Daescu Dan Dragomir-Daescu Ramanathan Kadirvel Roger J. Guillory David F. Kallmes David F. Kallmes |
| author_sort | Alexander A. Oliver |
| collection | DOAJ |
| description | IntroductionFlow diverters are specialized stents used to treat intracranial aneurysms. Bioresorbable flow diverters (BRFDs) have been proposed as the next-generation of flow diverter technology. BRFDs aim to occlude and heal the aneurysm before safely dissolving into the body, mitigating complications associated with the permanent presence of conventional flow diverters. We previously prototyped BRFDs using an iron-manganese-nitrogen (FeMnN) alloy and demonstrated their flow diversion functionality, radial strength, bioresorbability, and MRI compatibility in benchtop tests. In the current work, we investigated their aneurysm occlusion efficacy in vivo.MethodsElastase induced aneurysms were created in seven rabbits and BRFDs were deployed over the aneurysms for 3 months. Aneurysm occlusion efficacy and the biological response was assessed via angiography, gross dissection microscopy, and histology.ResultsThe BRFDs failed to occlude the aneurysms in 5/7 rabbits at the 3-month endpoint. The bioresorbable wires appeared to resorb too rapidly and fragment away from the aneurysm neck prior to becoming entirely encased in tissue and completely occluding the aneurysm. In 3/7 rabbits, some FeMnN wires remained over the aneurysm neck that were encased in tissue, partially covering the aneurysm neck. Histological analysis revealed that the wires, when present, were a suitable substrate over which tissue could develop. Therefore, we attribute the poor aneurysm occlusion efficacy to mechanical failure rather than an impaired biological healing response.ConclusionThe FeMnN BRFDs degraded too rapidly to effectively treat the rabbit elastase induced aneurysms. Future work will focus on developing BRFDs out of materials with a delayed resorption rate. |
| format | Article |
| id | doaj-art-d78491caa22344bc92d0ad54427ff446 |
| institution | DOAJ |
| issn | 2296-4185 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Bioengineering and Biotechnology |
| spelling | doaj-art-d78491caa22344bc92d0ad54427ff4462025-08-20T03:11:17ZengFrontiers Media S.A.Frontiers in Bioengineering and Biotechnology2296-41852025-02-011310.3389/fbioe.2025.15226961522696Evaluation of FeMnN alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm modelAlexander A. Oliver0Alexander A. Oliver1Alexander A. Oliver2Cem Bilgin3Jonathan Cortese4Jonathan Cortese5Esref A. Bayraktar6Daying Dai7Yong Hong Ding8Kent D. Carlson9Adam J. Griebel10Jeremy E. Schaffer11Mitchell L. Connon12Dan Dragomir-Daescu13Dan Dragomir-Daescu14Ramanathan Kadirvel15Roger J. Guillory16David F. Kallmes17David F. Kallmes18Biomedical Engineering and Physiology, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, United StatesRadiology, Mayo Clinic, Rochester, MN, United StatesPhysiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United StatesRadiology, Mayo Clinic, Rochester, MN, United StatesRadiology, Mayo Clinic, Rochester, MN, United StatesInterventional Neuroradiology (NEURI Vascular Center), Bicetre University Hospital, Le Kremlin-Bicetre, FranceRadiology, Mayo Clinic, Rochester, MN, United StatesRadiology, Mayo Clinic, Rochester, MN, United StatesRadiology, Mayo Clinic, Rochester, MN, United StatesPhysiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United StatesFort Wayne Metals, Fort Wayne, IN, United StatesFort Wayne Metals, Fort Wayne, IN, United StatesBiomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, United StatesBiomedical Engineering and Physiology, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, United StatesPhysiology and Biomedical Engineering, Mayo Clinic, Rochester, MN, United StatesNeurologic Surgery, Mayo Clinic, Rochester, MN, United StatesBiomedical Engineering, Medical College of Wisconsin, Milwaukee, WI, United StatesBiomedical Engineering and Physiology, Mayo Clinic Graduate School of Biomedical Sciences, Rochester, MN, United StatesRadiology, Mayo Clinic, Rochester, MN, United StatesIntroductionFlow diverters are specialized stents used to treat intracranial aneurysms. Bioresorbable flow diverters (BRFDs) have been proposed as the next-generation of flow diverter technology. BRFDs aim to occlude and heal the aneurysm before safely dissolving into the body, mitigating complications associated with the permanent presence of conventional flow diverters. We previously prototyped BRFDs using an iron-manganese-nitrogen (FeMnN) alloy and demonstrated their flow diversion functionality, radial strength, bioresorbability, and MRI compatibility in benchtop tests. In the current work, we investigated their aneurysm occlusion efficacy in vivo.MethodsElastase induced aneurysms were created in seven rabbits and BRFDs were deployed over the aneurysms for 3 months. Aneurysm occlusion efficacy and the biological response was assessed via angiography, gross dissection microscopy, and histology.ResultsThe BRFDs failed to occlude the aneurysms in 5/7 rabbits at the 3-month endpoint. The bioresorbable wires appeared to resorb too rapidly and fragment away from the aneurysm neck prior to becoming entirely encased in tissue and completely occluding the aneurysm. In 3/7 rabbits, some FeMnN wires remained over the aneurysm neck that were encased in tissue, partially covering the aneurysm neck. Histological analysis revealed that the wires, when present, were a suitable substrate over which tissue could develop. Therefore, we attribute the poor aneurysm occlusion efficacy to mechanical failure rather than an impaired biological healing response.ConclusionThe FeMnN BRFDs degraded too rapidly to effectively treat the rabbit elastase induced aneurysms. Future work will focus on developing BRFDs out of materials with a delayed resorption rate.https://www.frontiersin.org/articles/10.3389/fbioe.2025.1522696/fullflow diverterbioresorbablebioabsorbablebiodegradablestentaneurysm |
| spellingShingle | Alexander A. Oliver Alexander A. Oliver Alexander A. Oliver Cem Bilgin Jonathan Cortese Jonathan Cortese Esref A. Bayraktar Daying Dai Yong Hong Ding Kent D. Carlson Adam J. Griebel Jeremy E. Schaffer Mitchell L. Connon Dan Dragomir-Daescu Dan Dragomir-Daescu Ramanathan Kadirvel Roger J. Guillory David F. Kallmes David F. Kallmes Evaluation of FeMnN alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm model Frontiers in Bioengineering and Biotechnology flow diverter bioresorbable bioabsorbable biodegradable stent aneurysm |
| title | Evaluation of FeMnN alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm model |
| title_full | Evaluation of FeMnN alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm model |
| title_fullStr | Evaluation of FeMnN alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm model |
| title_full_unstemmed | Evaluation of FeMnN alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm model |
| title_short | Evaluation of FeMnN alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm model |
| title_sort | evaluation of femnn alloy bioresorbable flow diverters in the rabbit elastase induced aneurysm model |
| topic | flow diverter bioresorbable bioabsorbable biodegradable stent aneurysm |
| url | https://www.frontiersin.org/articles/10.3389/fbioe.2025.1522696/full |
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