Intrasplenic metastasis of appendiceal low-grade mucinous neoplasm – A case report and review of the literature
Low-grade appendiceal mucinous neoplasms (LAMNs) may lead to pseudomyxoma peritonei and require specialized surgical therapy. By pathological definition, these tumor entities exhibit neither invasive growth nor develop systemic or lymph node metastases. We report the case of a 43-year-old female pre...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-06-01
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| Series: | Current Problems in Cancer: Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S266662192500016X |
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| author | P. Meister J. Rawitzer M. Reschke H.A. Baba U. Neumann M. Kaths |
| author_facet | P. Meister J. Rawitzer M. Reschke H.A. Baba U. Neumann M. Kaths |
| author_sort | P. Meister |
| collection | DOAJ |
| description | Low-grade appendiceal mucinous neoplasms (LAMNs) may lead to pseudomyxoma peritonei and require specialized surgical therapy. By pathological definition, these tumor entities exhibit neither invasive growth nor develop systemic or lymph node metastases. We report the case of a 43-year-old female presenting with a metachronous splenic metastasis of low-grade pseudomyxoma peritonei four years after surgical therapy. The patient was treated successfully via laparoscopic splenectomy. While the spleen itself is an extremely rare location for metastasizing colonic cancer, a LAMN metastasis in this location has not been previously described. A literature review of pseudomyxoma recurrence reveals that LAMNs might indeed recur in extraperitoneal locations, questioning their pathophysiological definition of non-metastasizing behavior. |
| format | Article |
| id | doaj-art-d7812fc649c444e29404ba4a032f4f19 |
| institution | DOAJ |
| issn | 2666-6219 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Current Problems in Cancer: Case Reports |
| spelling | doaj-art-d7812fc649c444e29404ba4a032f4f192025-08-20T02:49:55ZengElsevierCurrent Problems in Cancer: Case Reports2666-62192025-06-011810036410.1016/j.cpccr.2025.100364Intrasplenic metastasis of appendiceal low-grade mucinous neoplasm – A case report and review of the literatureP. Meister0J. Rawitzer1M. Reschke2H.A. Baba3U. Neumann4M. Kaths5University Hospital Essen, Germany, Department of General-, Visceral-, Vascular-, and Transplantation Surgery, Hufelandstr. 55, 45147 Essen, Germany; Corresponding author.University Hospital Essen, Germany, Institute of Pathology, Hufelandstr. 55, 45147 Essen, GermanyUniversity Hospital Essen, Germany, Department of General-, Visceral-, Vascular-, and Transplantation Surgery, Hufelandstr. 55, 45147 Essen, GermanyUniversity Hospital Essen, Germany, Institute of Pathology, Hufelandstr. 55, 45147 Essen, GermanyUniversity Hospital Essen, Germany, Department of General-, Visceral-, Vascular-, and Transplantation Surgery, Hufelandstr. 55, 45147 Essen, GermanyUniversity Hospital Essen, Germany, Department of General-, Visceral-, Vascular-, and Transplantation Surgery, Hufelandstr. 55, 45147 Essen, GermanyLow-grade appendiceal mucinous neoplasms (LAMNs) may lead to pseudomyxoma peritonei and require specialized surgical therapy. By pathological definition, these tumor entities exhibit neither invasive growth nor develop systemic or lymph node metastases. We report the case of a 43-year-old female presenting with a metachronous splenic metastasis of low-grade pseudomyxoma peritonei four years after surgical therapy. The patient was treated successfully via laparoscopic splenectomy. While the spleen itself is an extremely rare location for metastasizing colonic cancer, a LAMN metastasis in this location has not been previously described. A literature review of pseudomyxoma recurrence reveals that LAMNs might indeed recur in extraperitoneal locations, questioning their pathophysiological definition of non-metastasizing behavior.http://www.sciencedirect.com/science/article/pii/S266662192500016XLow grade mucinous neoplasmLAMNPseudomyxoma peritonei appendixSpleenMetastasisCase report |
| spellingShingle | P. Meister J. Rawitzer M. Reschke H.A. Baba U. Neumann M. Kaths Intrasplenic metastasis of appendiceal low-grade mucinous neoplasm – A case report and review of the literature Current Problems in Cancer: Case Reports Low grade mucinous neoplasm LAMN Pseudomyxoma peritonei appendix Spleen Metastasis Case report |
| title | Intrasplenic metastasis of appendiceal low-grade mucinous neoplasm – A case report and review of the literature |
| title_full | Intrasplenic metastasis of appendiceal low-grade mucinous neoplasm – A case report and review of the literature |
| title_fullStr | Intrasplenic metastasis of appendiceal low-grade mucinous neoplasm – A case report and review of the literature |
| title_full_unstemmed | Intrasplenic metastasis of appendiceal low-grade mucinous neoplasm – A case report and review of the literature |
| title_short | Intrasplenic metastasis of appendiceal low-grade mucinous neoplasm – A case report and review of the literature |
| title_sort | intrasplenic metastasis of appendiceal low grade mucinous neoplasm a case report and review of the literature |
| topic | Low grade mucinous neoplasm LAMN Pseudomyxoma peritonei appendix Spleen Metastasis Case report |
| url | http://www.sciencedirect.com/science/article/pii/S266662192500016X |
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