Novel use of carboplatin, etoposide and durvalumab as neoadjuvant therapy in treatment of small cell bladder cancer
Small cell carcinoma of the bladder (SCCB) is a rare and aggressive variant of bladder cancer requiring multimodal treatment. We present a case of an 82-year-old male with SCCB with bulky pelvic adenopathy treated with a novel neoadjuvant combination of carboplatin, etoposide, and durvalumab with co...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-09-01
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| Series: | Urology Case Reports |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2214442025002360 |
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| _version_ | 1849233576921399296 |
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| author | Victoria Gonzalez Edward Linton Timothy Boyce Laila Dahmoush Helen Y. Hougen |
| author_facet | Victoria Gonzalez Edward Linton Timothy Boyce Laila Dahmoush Helen Y. Hougen |
| author_sort | Victoria Gonzalez |
| collection | DOAJ |
| description | Small cell carcinoma of the bladder (SCCB) is a rare and aggressive variant of bladder cancer requiring multimodal treatment. We present a case of an 82-year-old male with SCCB with bulky pelvic adenopathy treated with a novel neoadjuvant combination of carboplatin, etoposide, and durvalumab with complete response of the small cell component. We also describe a rare complication of retinopathy resulting from this treatment. This study presents the potential efficacy and promise of adding immunotherapy to neoadjuvant chemotherapy for SCCB to achieve a long-term cure. |
| format | Article |
| id | doaj-art-d7769a5e42da48988a1acaa6560810a9 |
| institution | Kabale University |
| issn | 2214-4420 |
| language | English |
| publishDate | 2025-09-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Urology Case Reports |
| spelling | doaj-art-d7769a5e42da48988a1acaa6560810a92025-08-20T05:06:54ZengElsevierUrology Case Reports2214-44202025-09-016210316510.1016/j.eucr.2025.103165Novel use of carboplatin, etoposide and durvalumab as neoadjuvant therapy in treatment of small cell bladder cancerVictoria Gonzalez0Edward Linton1Timothy Boyce2Laila Dahmoush3Helen Y. Hougen4Department of Urology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA, 52242, USA; Corresponding author. 200 Hawkins Dr, Iowa City, IA, 52242, USA.Department of Ophthalmology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA, 52242, USADepartment of Ophthalmology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA, 52242, USADepartment of Pathology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA, 52242, USADepartment of Urology, University of Iowa Hospitals and Clinics, 200 Hawkins Dr, Iowa City, IA, 52242, USASmall cell carcinoma of the bladder (SCCB) is a rare and aggressive variant of bladder cancer requiring multimodal treatment. We present a case of an 82-year-old male with SCCB with bulky pelvic adenopathy treated with a novel neoadjuvant combination of carboplatin, etoposide, and durvalumab with complete response of the small cell component. We also describe a rare complication of retinopathy resulting from this treatment. This study presents the potential efficacy and promise of adding immunotherapy to neoadjuvant chemotherapy for SCCB to achieve a long-term cure.http://www.sciencedirect.com/science/article/pii/S2214442025002360Urinary bladder neoplasmsSmall cell carcinomaImmune checkpoint inhibitorRetinopathy |
| spellingShingle | Victoria Gonzalez Edward Linton Timothy Boyce Laila Dahmoush Helen Y. Hougen Novel use of carboplatin, etoposide and durvalumab as neoadjuvant therapy in treatment of small cell bladder cancer Urology Case Reports Urinary bladder neoplasms Small cell carcinoma Immune checkpoint inhibitor Retinopathy |
| title | Novel use of carboplatin, etoposide and durvalumab as neoadjuvant therapy in treatment of small cell bladder cancer |
| title_full | Novel use of carboplatin, etoposide and durvalumab as neoadjuvant therapy in treatment of small cell bladder cancer |
| title_fullStr | Novel use of carboplatin, etoposide and durvalumab as neoadjuvant therapy in treatment of small cell bladder cancer |
| title_full_unstemmed | Novel use of carboplatin, etoposide and durvalumab as neoadjuvant therapy in treatment of small cell bladder cancer |
| title_short | Novel use of carboplatin, etoposide and durvalumab as neoadjuvant therapy in treatment of small cell bladder cancer |
| title_sort | novel use of carboplatin etoposide and durvalumab as neoadjuvant therapy in treatment of small cell bladder cancer |
| topic | Urinary bladder neoplasms Small cell carcinoma Immune checkpoint inhibitor Retinopathy |
| url | http://www.sciencedirect.com/science/article/pii/S2214442025002360 |
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