Praziquantel Failure in the Treatment of Fasciola hepatica
A case of human fascioliasis is presented in which the patient remained symptomatic after treatment with praziquantel and other agents but eventually responded to bithionol. The difficulties in finding an efficacious and tolerable drug therapy for this condition are reviewed with reference to the li...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
1992-01-01
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| Series: | Canadian Journal of Infectious Diseases |
| Online Access: | http://dx.doi.org/10.1155/1992/864093 |
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| _version_ | 1850172079498854400 |
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| author | David Michael Patrick Judith Isaac-Renton |
| author_facet | David Michael Patrick Judith Isaac-Renton |
| author_sort | David Michael Patrick |
| collection | DOAJ |
| description | A case of human fascioliasis is presented in which the patient remained symptomatic after treatment with praziquantel and other agents but eventually responded to bithionol. The difficulties in finding an efficacious and tolerable drug therapy for this condition are reviewed with reference to the life cycle and pathogenesis of the parasite. It is concluded that while bithionol remains the current drug of choice, triclabendazole may play a dominant role in the near future. |
| format | Article |
| id | doaj-art-d7743051003e4bf1bf617eb4ab0c67bf |
| institution | OA Journals |
| issn | 1180-2332 |
| language | English |
| publishDate | 1992-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Infectious Diseases |
| spelling | doaj-art-d7743051003e4bf1bf617eb4ab0c67bf2025-08-20T02:20:09ZengWileyCanadian Journal of Infectious Diseases1180-23321992-01-0131333610.1155/1992/864093Praziquantel Failure in the Treatment of Fasciola hepaticaDavid Michael Patrick0Judith Isaac-Renton1Divisions of Microbiology and Infectious Diseases, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, CanadaDivisions of Microbiology and Infectious Diseases, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, CanadaA case of human fascioliasis is presented in which the patient remained symptomatic after treatment with praziquantel and other agents but eventually responded to bithionol. The difficulties in finding an efficacious and tolerable drug therapy for this condition are reviewed with reference to the life cycle and pathogenesis of the parasite. It is concluded that while bithionol remains the current drug of choice, triclabendazole may play a dominant role in the near future.http://dx.doi.org/10.1155/1992/864093 |
| spellingShingle | David Michael Patrick Judith Isaac-Renton Praziquantel Failure in the Treatment of Fasciola hepatica Canadian Journal of Infectious Diseases |
| title | Praziquantel Failure in the Treatment of Fasciola hepatica |
| title_full | Praziquantel Failure in the Treatment of Fasciola hepatica |
| title_fullStr | Praziquantel Failure in the Treatment of Fasciola hepatica |
| title_full_unstemmed | Praziquantel Failure in the Treatment of Fasciola hepatica |
| title_short | Praziquantel Failure in the Treatment of Fasciola hepatica |
| title_sort | praziquantel failure in the treatment of fasciola hepatica |
| url | http://dx.doi.org/10.1155/1992/864093 |
| work_keys_str_mv | AT davidmichaelpatrick praziquantelfailureinthetreatmentoffasciolahepatica AT judithisaacrenton praziquantelfailureinthetreatmentoffasciolahepatica |