The Effect of Passive Smoking during Pregnancy on the Central Nervous System Structure and Behaviour of the Offspring
Exposure to tobacco smoke during pregnancy is considered a major preventable risk factor for morbidity and mortality of the mother and the foetus. This study aims to investigate the effect of passive smoking during pregnancy on the structural integrity of the central nervous system (CNS) of the offs...
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An-Najah National University
2014-09-01
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| Series: | مجلة جامعة النجاح للأبحاث العلوم الطبيعية |
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| Online Access: | https://journals.najah.edu/media/journals/full_texts/5_dyIGXu2.pdf |
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| author | Omar Abuzant Waseem Khraim Watheq Sharqia Waleed Ajaj Walid Basha |
| author_facet | Omar Abuzant Waseem Khraim Watheq Sharqia Waleed Ajaj Walid Basha |
| author_sort | Omar Abuzant |
| collection | DOAJ |
| description | Exposure to tobacco smoke during pregnancy is considered a major preventable risk factor for morbidity and mortality of the mother and the foetus. This study aims to investigate the effect of passive smoking during pregnancy on the structural integrity of the central nervous system (CNS) of the offspring, and to assess their neurobehavioral functions including short term memory, anxiety and social interactions. For this 35 pregnant hamsters were divided into 5 groups, based upon the pregnancy trimesters they were exposed to smoke in (during the 1st trimester or the 2nd and 3rd trimesters together) as well as the duration of exposure (4 or 6 hours). The 35 pregnant hamsters produced 78 offspring, which were evaluated at age 8 weeks for memory function by T-maze test, anxiety using marble burying test and social behaviour by social dominance test. They were also examined by CT scan subsequently for gross structural abnormalities in the CNS. The results demonstrated that there is a significant correlation between exposure to passive smoking during the 1st trimester and the presence of short-term memory impairment (p= 0.047), as well as increasing anxiety level (p=0.024). Exposures during the 2nd and 3rd trimesters were also associated with short-term memory dysfunction, with no effect on anxiety level. CT reports showed lumbar canal stenosis in a significant number of offspring who were exposed to 6 hours of cigarette smoke during the 1st trimester of pregnancy. Our results conclude that passive smoking during pregnancy is dangerous to the CNS development of the foetus as was evident by its effect on the behaviour of the offspring and structural integrity of their CNS. |
| format | Article |
| id | doaj-art-d772f5cc603e4e13b573cb7d9477ee02 |
| institution | Kabale University |
| issn | 1727-2114 2311-8865 |
| language | English |
| publishDate | 2014-09-01 |
| publisher | An-Najah National University |
| record_format | Article |
| series | مجلة جامعة النجاح للأبحاث العلوم الطبيعية |
| spelling | doaj-art-d772f5cc603e4e13b573cb7d9477ee022025-08-20T04:00:44ZengAn-Najah National Universityمجلة جامعة النجاح للأبحاث العلوم الطبيعية1727-21142311-88652014-09-01291738410.35552/anujr.a.29.1.1159The Effect of Passive Smoking during Pregnancy on the Central Nervous System Structure and Behaviour of the OffspringOmar Abuzant0Waseem Khraim1Watheq Sharqia2Waleed Ajaj3Walid Basha4Department of Physiology, School of Medicine and health sciences, An-Najah National University, Nablus, PalestineNoneNoneNoneFaculty of Medicine & Health Sciences, An-Najah National University, Nablus, PalestineExposure to tobacco smoke during pregnancy is considered a major preventable risk factor for morbidity and mortality of the mother and the foetus. This study aims to investigate the effect of passive smoking during pregnancy on the structural integrity of the central nervous system (CNS) of the offspring, and to assess their neurobehavioral functions including short term memory, anxiety and social interactions. For this 35 pregnant hamsters were divided into 5 groups, based upon the pregnancy trimesters they were exposed to smoke in (during the 1st trimester or the 2nd and 3rd trimesters together) as well as the duration of exposure (4 or 6 hours). The 35 pregnant hamsters produced 78 offspring, which were evaluated at age 8 weeks for memory function by T-maze test, anxiety using marble burying test and social behaviour by social dominance test. They were also examined by CT scan subsequently for gross structural abnormalities in the CNS. The results demonstrated that there is a significant correlation between exposure to passive smoking during the 1st trimester and the presence of short-term memory impairment (p= 0.047), as well as increasing anxiety level (p=0.024). Exposures during the 2nd and 3rd trimesters were also associated with short-term memory dysfunction, with no effect on anxiety level. CT reports showed lumbar canal stenosis in a significant number of offspring who were exposed to 6 hours of cigarette smoke during the 1st trimester of pregnancy. Our results conclude that passive smoking during pregnancy is dangerous to the CNS development of the foetus as was evident by its effect on the behaviour of the offspring and structural integrity of their CNS.https://journals.najah.edu/media/journals/full_texts/5_dyIGXu2.pdfbehavioral developmentcns integrity.passive smoking |
| spellingShingle | Omar Abuzant Waseem Khraim Watheq Sharqia Waleed Ajaj Walid Basha The Effect of Passive Smoking during Pregnancy on the Central Nervous System Structure and Behaviour of the Offspring مجلة جامعة النجاح للأبحاث العلوم الطبيعية behavioral development cns integrity. passive smoking |
| title | The Effect of Passive Smoking during Pregnancy on the Central Nervous System Structure and Behaviour of the Offspring |
| title_full | The Effect of Passive Smoking during Pregnancy on the Central Nervous System Structure and Behaviour of the Offspring |
| title_fullStr | The Effect of Passive Smoking during Pregnancy on the Central Nervous System Structure and Behaviour of the Offspring |
| title_full_unstemmed | The Effect of Passive Smoking during Pregnancy on the Central Nervous System Structure and Behaviour of the Offspring |
| title_short | The Effect of Passive Smoking during Pregnancy on the Central Nervous System Structure and Behaviour of the Offspring |
| title_sort | effect of passive smoking during pregnancy on the central nervous system structure and behaviour of the offspring |
| topic | behavioral development cns integrity. passive smoking |
| url | https://journals.najah.edu/media/journals/full_texts/5_dyIGXu2.pdf |
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