Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study.
Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used Mendelian randomization (MR) to explore causal relationships between the degree of alcohol consumption...
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Public Library of Science (PLoS)
2021-01-01
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| author | Joanna Lankester Daniela Zanetti Erik Ingelsson Themistocles L Assimes |
| author_facet | Joanna Lankester Daniela Zanetti Erik Ingelsson Themistocles L Assimes |
| author_sort | Joanna Lankester |
| collection | DOAJ |
| description | Observational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used Mendelian randomization (MR) to explore causal relationships between the degree of alcohol consumption and several cardiometabolic traits in the UK Biobank. Using the well-established ADH1B Arg47His variant (rs1229984) and up to 24 additional SNPs recently found to be associated with alcohol consumption in an independent dataset as instruments, we conducted two-stage least squares and inverse weighted variance MR analyses, both as one-sample analyses in the UK Biobank and as two-sample analyses in external consortia. In the UK Biobank inverse variance weighted analyses, we found that one additional drink of alcohol per day was positively associated with systolic blood pressure (beta = 2.65 mmHg [1.40, 3.89]), hemorrhagic stroke (OR = 2.25 [1.41, 3.60]), and atrial fibrillation (OR = 1.26 [1.07, 1.48]), which were replicated in multivariable analyses. Alcohol was also associated with all cardiovascular disease and all-cause death. A positive association with myocardial infarction did not replicate in multivariable analysis, with suggestive mediation through blood pressure; similarly, a positive association between alcohol use with type 2 diabetes was mitigated by BMI in multivariable analysis. Findings were generally null in replication with two-sample analyses. Alcohol was not protective for any disease outcome with any analysis method, dataset, or strata. Stratifications by sex and smoking in the UK Biobank revealed higher point estimates of risk for several outcomes for men and mixed results for smoking strata, but no statistically significant heterogeneity. Our results are consistent with an overall harmful and/or null effect of alcohol on cardiometabolic health at all levels of use and suggest that even moderate alcohol use should not be promoted as a part of a healthy diet and lifestyle. |
| format | Article |
| id | doaj-art-d7710c000f8c4f35b56b108eeacf0421 |
| institution | Kabale University |
| issn | 1932-6203 |
| language | English |
| publishDate | 2021-01-01 |
| publisher | Public Library of Science (PLoS) |
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| series | PLoS ONE |
| spelling | doaj-art-d7710c000f8c4f35b56b108eeacf04212025-08-20T03:25:34ZengPublic Library of Science (PLoS)PLoS ONE1932-62032021-01-01168e025580110.1371/journal.pone.0255801Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study.Joanna LankesterDaniela ZanettiErik IngelssonThemistocles L AssimesObservational studies suggest alcohol use promotes the development of some adverse cardiometabolic traits but protects against others including outcomes related to coronary artery disease. We used Mendelian randomization (MR) to explore causal relationships between the degree of alcohol consumption and several cardiometabolic traits in the UK Biobank. Using the well-established ADH1B Arg47His variant (rs1229984) and up to 24 additional SNPs recently found to be associated with alcohol consumption in an independent dataset as instruments, we conducted two-stage least squares and inverse weighted variance MR analyses, both as one-sample analyses in the UK Biobank and as two-sample analyses in external consortia. In the UK Biobank inverse variance weighted analyses, we found that one additional drink of alcohol per day was positively associated with systolic blood pressure (beta = 2.65 mmHg [1.40, 3.89]), hemorrhagic stroke (OR = 2.25 [1.41, 3.60]), and atrial fibrillation (OR = 1.26 [1.07, 1.48]), which were replicated in multivariable analyses. Alcohol was also associated with all cardiovascular disease and all-cause death. A positive association with myocardial infarction did not replicate in multivariable analysis, with suggestive mediation through blood pressure; similarly, a positive association between alcohol use with type 2 diabetes was mitigated by BMI in multivariable analysis. Findings were generally null in replication with two-sample analyses. Alcohol was not protective for any disease outcome with any analysis method, dataset, or strata. Stratifications by sex and smoking in the UK Biobank revealed higher point estimates of risk for several outcomes for men and mixed results for smoking strata, but no statistically significant heterogeneity. Our results are consistent with an overall harmful and/or null effect of alcohol on cardiometabolic health at all levels of use and suggest that even moderate alcohol use should not be promoted as a part of a healthy diet and lifestyle.https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0255801&type=printable |
| spellingShingle | Joanna Lankester Daniela Zanetti Erik Ingelsson Themistocles L Assimes Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study. PLoS ONE |
| title | Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study. |
| title_full | Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study. |
| title_fullStr | Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study. |
| title_full_unstemmed | Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study. |
| title_short | Alcohol use and cardiometabolic risk in the UK Biobank: A Mendelian randomization study. |
| title_sort | alcohol use and cardiometabolic risk in the uk biobank a mendelian randomization study |
| url | https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0255801&type=printable |
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