β-Amyloids and Immune Responses Associated with Alzheimer’s Disease
Alzheimer’s disease (AD) is associated with the accumulation of β-amyloids (Aβs) and the formation of Aβ plaques in the brain. Various structural forms and isoforms of Aβs that have variable propensities for oligomerization and toxicity and may differentially affect the development of AD have been i...
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| Language: | English |
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MDPI AG
2024-09-01
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| Online Access: | https://www.mdpi.com/2073-4409/13/19/1624 |
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| author | Elizaveta Kolobova Irina Petrushanko Vladimir Mitkevich Alexander A Makarov Irina L Grigorova |
| author_facet | Elizaveta Kolobova Irina Petrushanko Vladimir Mitkevich Alexander A Makarov Irina L Grigorova |
| author_sort | Elizaveta Kolobova |
| collection | DOAJ |
| description | Alzheimer’s disease (AD) is associated with the accumulation of β-amyloids (Aβs) and the formation of Aβ plaques in the brain. Various structural forms and isoforms of Aβs that have variable propensities for oligomerization and toxicity and may differentially affect the development of AD have been identified. In addition, there is evidence that β-amyloids are engaged in complex interactions with the innate and adaptive immune systems, both of which may also play a role in the regulation of AD onset and progression. In this review, we discuss what is currently known about the intricate interplay between β-amyloids and the immune response to Aβs with a more in-depth focus on the possible roles of B cells in the pathogenesis of AD. |
| format | Article |
| id | doaj-art-d77064aa5d9e45b99467274fe6351d42 |
| institution | OA Journals |
| issn | 2073-4409 |
| language | English |
| publishDate | 2024-09-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj-art-d77064aa5d9e45b99467274fe6351d422025-08-20T01:47:42ZengMDPI AGCells2073-44092024-09-011319162410.3390/cells13191624β-Amyloids and Immune Responses Associated with Alzheimer’s DiseaseElizaveta Kolobova0Irina Petrushanko1Vladimir Mitkevich2Alexander A Makarov3Irina L Grigorova4Engelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, RussiaEngelhardt Institute of Molecular Biology, Russian Academy of Sciences, 119991 Moscow, RussiaAlzheimer’s disease (AD) is associated with the accumulation of β-amyloids (Aβs) and the formation of Aβ plaques in the brain. Various structural forms and isoforms of Aβs that have variable propensities for oligomerization and toxicity and may differentially affect the development of AD have been identified. In addition, there is evidence that β-amyloids are engaged in complex interactions with the innate and adaptive immune systems, both of which may also play a role in the regulation of AD onset and progression. In this review, we discuss what is currently known about the intricate interplay between β-amyloids and the immune response to Aβs with a more in-depth focus on the possible roles of B cells in the pathogenesis of AD.https://www.mdpi.com/2073-4409/13/19/1624Alzheimer’s diseaseβ-amyloidpost-translational modifications of β-amyloidimmune responseB cellsantibody |
| spellingShingle | Elizaveta Kolobova Irina Petrushanko Vladimir Mitkevich Alexander A Makarov Irina L Grigorova β-Amyloids and Immune Responses Associated with Alzheimer’s Disease Cells Alzheimer’s disease β-amyloid post-translational modifications of β-amyloid immune response B cells antibody |
| title | β-Amyloids and Immune Responses Associated with Alzheimer’s Disease |
| title_full | β-Amyloids and Immune Responses Associated with Alzheimer’s Disease |
| title_fullStr | β-Amyloids and Immune Responses Associated with Alzheimer’s Disease |
| title_full_unstemmed | β-Amyloids and Immune Responses Associated with Alzheimer’s Disease |
| title_short | β-Amyloids and Immune Responses Associated with Alzheimer’s Disease |
| title_sort | β amyloids and immune responses associated with alzheimer s disease |
| topic | Alzheimer’s disease β-amyloid post-translational modifications of β-amyloid immune response B cells antibody |
| url | https://www.mdpi.com/2073-4409/13/19/1624 |
| work_keys_str_mv | AT elizavetakolobova bamyloidsandimmuneresponsesassociatedwithalzheimersdisease AT irinapetrushanko bamyloidsandimmuneresponsesassociatedwithalzheimersdisease AT vladimirmitkevich bamyloidsandimmuneresponsesassociatedwithalzheimersdisease AT alexanderamakarov bamyloidsandimmuneresponsesassociatedwithalzheimersdisease AT irinalgrigorova bamyloidsandimmuneresponsesassociatedwithalzheimersdisease |