Hepatocellular Metabolic Profile: Understanding Post-Thawing Metabolic Shift in Primary Hepatocytes In Vitro

Hepatocellular Metabolic Profile: Understanding Post-Thawing Metabolic Shift in Primary Hepatocytes In Vitro

Primary human hepatocytes (PHHs) are widely used as in vitro models for liver function and drug metabolism studies, yet their metabolic stability post-thawing remains an open question. To better characterize early metabolic changes, we conducted a time-course experiment using liquid chromatography-t...

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Bibliographic Details
Main Authors: Salvator Palmisano, Joshua D. Breidenbach, Brett R. Blackwell, Tara Harvey, Kes A. Luchini, M. Grace Thornhill, Erick S. LeBrun, Phillip Mach, Trevor Glaros, Emilio S. Rivera
Format: Article
Language:English
Published: MDPI AG 2025-05-01
Series:Cells
Subjects:
primary human hepatocytes (PHHs)
liver metabolism
LC-MS/MS metabolomics
metabolic profiling
in vitro liver models
post-thawing hepatocyte stability
Online Access:https://www.mdpi.com/2073-4409/14/11/803
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