From transmission to adaptive evolution: genomic surveillance of Getah virus
Getah virus (GETV) is a member of the Alphavirus of the Togaviridae. It is a single-stranded positive-RNA virus that is mainly transmitted by mosquitoes. In recent years, the spread of GETV has become increasingly serious, causing serious losses to the animal economy and posing a potential threat to...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2025-06-01
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| Series: | Frontiers in Cellular and Infection Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1513392/full |
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| author | Yuge Yuan Yujia Hao Chengcheng Peng Duo Zhang Duo Zhang Wenzhou Ma Pengpeng Xiao Nan Li |
| author_facet | Yuge Yuan Yujia Hao Chengcheng Peng Duo Zhang Duo Zhang Wenzhou Ma Pengpeng Xiao Nan Li |
| author_sort | Yuge Yuan |
| collection | DOAJ |
| description | Getah virus (GETV) is a member of the Alphavirus of the Togaviridae. It is a single-stranded positive-RNA virus that is mainly transmitted by mosquitoes. In recent years, the spread of GETV has become increasingly serious, causing serious losses to the animal economy and posing a potential threat to public health. GETV infected animals extend from traditional domestic animals such as horses and pigs to cattle, foxes and other animals. Especially in China, the virus has been detected in many provinces in recent years. In addition, GETV-specific antibodies were detected in healthy humans. However, the threat posed by GETV in China has not received enough attention. In this study, we downloaded all available GETV genome-wide serials (82 serials in total) from the NCBI as of December 2023. We integrate multiple bioinformatics approaches to understand the characteristics of GETV from the perspectives of epidemiology, virus-host co-evolution, and viral adaptation analysis. The results of this study show that GETV is rapidly expanding its host range and geographical distribution at high evolutionary rates due to the lack of commercially available vaccines. Second, we clearly reveal the cross-species transmission of GETV. Finally, we identified important adaptive and active selection sites. GETV and its media are widely distributed in China, and new host infections continue to appear. Therefore, strengthening surveillance and prevention to avoid serious losses to the pandemic is an important task we face today. |
| format | Article |
| id | doaj-art-d764e4cbf0114cc89b8321aea60e39ec |
| institution | DOAJ |
| issn | 2235-2988 |
| language | English |
| publishDate | 2025-06-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Cellular and Infection Microbiology |
| spelling | doaj-art-d764e4cbf0114cc89b8321aea60e39ec2025-08-20T03:07:21ZengFrontiers Media S.A.Frontiers in Cellular and Infection Microbiology2235-29882025-06-011510.3389/fcimb.2025.15133921513392From transmission to adaptive evolution: genomic surveillance of Getah virusYuge Yuan0Yujia Hao1Chengcheng Peng2Duo Zhang3Duo Zhang4Wenzhou Ma5Pengpeng Xiao6Nan Li7Wenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, ChinaWenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, ChinaWenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, ChinaWenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, ChinaCollege of Veterinary Medicine, Jilin University, Changchun, ChinaWenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, ChinaWenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, ChinaWenzhou Key Laboratory for Virology and Immunology, Institute of Virology, Wenzhou University, Wenzhou, ChinaGetah virus (GETV) is a member of the Alphavirus of the Togaviridae. It is a single-stranded positive-RNA virus that is mainly transmitted by mosquitoes. In recent years, the spread of GETV has become increasingly serious, causing serious losses to the animal economy and posing a potential threat to public health. GETV infected animals extend from traditional domestic animals such as horses and pigs to cattle, foxes and other animals. Especially in China, the virus has been detected in many provinces in recent years. In addition, GETV-specific antibodies were detected in healthy humans. However, the threat posed by GETV in China has not received enough attention. In this study, we downloaded all available GETV genome-wide serials (82 serials in total) from the NCBI as of December 2023. We integrate multiple bioinformatics approaches to understand the characteristics of GETV from the perspectives of epidemiology, virus-host co-evolution, and viral adaptation analysis. The results of this study show that GETV is rapidly expanding its host range and geographical distribution at high evolutionary rates due to the lack of commercially available vaccines. Second, we clearly reveal the cross-species transmission of GETV. Finally, we identified important adaptive and active selection sites. GETV and its media are widely distributed in China, and new host infections continue to appear. Therefore, strengthening surveillance and prevention to avoid serious losses to the pandemic is an important task we face today.https://www.frontiersin.org/articles/10.3389/fcimb.2025.1513392/fullGetah virusepidemiological situationhost rangecross-speciesadaptive evolution |
| spellingShingle | Yuge Yuan Yujia Hao Chengcheng Peng Duo Zhang Duo Zhang Wenzhou Ma Pengpeng Xiao Nan Li From transmission to adaptive evolution: genomic surveillance of Getah virus Frontiers in Cellular and Infection Microbiology Getah virus epidemiological situation host range cross-species adaptive evolution |
| title | From transmission to adaptive evolution: genomic surveillance of Getah virus |
| title_full | From transmission to adaptive evolution: genomic surveillance of Getah virus |
| title_fullStr | From transmission to adaptive evolution: genomic surveillance of Getah virus |
| title_full_unstemmed | From transmission to adaptive evolution: genomic surveillance of Getah virus |
| title_short | From transmission to adaptive evolution: genomic surveillance of Getah virus |
| title_sort | from transmission to adaptive evolution genomic surveillance of getah virus |
| topic | Getah virus epidemiological situation host range cross-species adaptive evolution |
| url | https://www.frontiersin.org/articles/10.3389/fcimb.2025.1513392/full |
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