Tumor budding and poorly differentiated clusters as a biological continuum in colorectal cancer invasion and prognosis

Tumor budding and poorly differentiated clusters as a biological continuum in colorectal cancer invasion and prognosis

Abstract Tumor budding (TB) and poorly differentiated clusters (PDCs) are features of infiltrative growth patterns and powerful independent prognostic factors in colorectal cancer (CRC), yet the underlying biological mechanisms behind their role in CRC invasion is less understood. The aim of this st...

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Main Authors: Tariq Sami Haddad, John-Melle Bokhorst, Luuk van den Dobbelsteen, Sonay K. Öztürk, Elias Baumann, Shannon van Vliet, Kiek Verrijp, Nigel B Jamieson, Colin Wood, Martin D. Berger, Richard Kirsch, Marco Aben, Natasja Rutgers, Hideki Ueno, Francesco Ciompi, Femke Simmer, Jeroen van der Laak, Alessandro Lugli, Inti Zlobec, Iris Nagtegaal
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-00866-x
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