Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis
Objective. To assess the effectiveness and safety of melatonin for perimenopausal and postmenopausal women with osteopenia. Methods. In this meta-analysis, data from randomized controlled trials were obtained to assess the effects of melatonin versus placebo or western medicine in perimenopausal and...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2019-01-01
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| Series: | International Journal of Endocrinology |
| Online Access: | http://dx.doi.org/10.1155/2019/5151678 |
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| _version_ | 1832562910342152192 |
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| author | Tingting Bao Liuting Zeng Kailin Yang Yuehua Li Fengying Ren Yulong Zhang Ziren Gao |
| author_facet | Tingting Bao Liuting Zeng Kailin Yang Yuehua Li Fengying Ren Yulong Zhang Ziren Gao |
| author_sort | Tingting Bao |
| collection | DOAJ |
| description | Objective. To assess the effectiveness and safety of melatonin for perimenopausal and postmenopausal women with osteopenia. Methods. In this meta-analysis, data from randomized controlled trials were obtained to assess the effects of melatonin versus placebo or western medicine in perimenopausal and postmenopausal women with osteopenia. The study’s registration number is CRD42018086238. The primary outcomes included bone mineral density (BMD) and T-score. Result. From 551 articles retrieved, three trials involving 121 patients were included. Due to the high-to-substantial heterogeneity (BMD: I2=96.9%, P=0.000; T-score: I2=74.9%, and P=0.019), the statistical analysis of BMD and T-score was abandoned. A systematic review was undergone for the two outcomes. Compared with the control group, melatonin may increase osteocalcin (WMD 4.97; 95% CI 3.14, 6.79; P<0.00001). Conclusion. Based on current evidence, melatonin might be used as a safe nutritional supplement to improve bone density in perimenopausal and postmenopausal women, but its efficacy needs to be further affirmed. |
| format | Article |
| id | doaj-art-d7648154c56f4a86ad35cb273b02d239 |
| institution | Kabale University |
| issn | 1687-8337 1687-8345 |
| language | English |
| publishDate | 2019-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | International Journal of Endocrinology |
| spelling | doaj-art-d7648154c56f4a86ad35cb273b02d2392025-02-03T01:21:31ZengWileyInternational Journal of Endocrinology1687-83371687-83452019-01-01201910.1155/2019/51516785151678Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-AnalysisTingting Bao0Liuting Zeng1Kailin Yang2Yuehua Li3Fengying Ren4Yulong Zhang5Ziren Gao6Beijing University of Chinese Medicine, Beijing 100029, ChinaHunan University of Chinese Medicine, Changsha, Hunan, ChinaHunan University of Chinese Medicine, Changsha, Hunan, ChinaXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaBeijing University of Chinese Medicine, Beijing 100029, ChinaXiyuan Hospital, China Academy of Chinese Medical Sciences, Beijing, ChinaObjective. To assess the effectiveness and safety of melatonin for perimenopausal and postmenopausal women with osteopenia. Methods. In this meta-analysis, data from randomized controlled trials were obtained to assess the effects of melatonin versus placebo or western medicine in perimenopausal and postmenopausal women with osteopenia. The study’s registration number is CRD42018086238. The primary outcomes included bone mineral density (BMD) and T-score. Result. From 551 articles retrieved, three trials involving 121 patients were included. Due to the high-to-substantial heterogeneity (BMD: I2=96.9%, P=0.000; T-score: I2=74.9%, and P=0.019), the statistical analysis of BMD and T-score was abandoned. A systematic review was undergone for the two outcomes. Compared with the control group, melatonin may increase osteocalcin (WMD 4.97; 95% CI 3.14, 6.79; P<0.00001). Conclusion. Based on current evidence, melatonin might be used as a safe nutritional supplement to improve bone density in perimenopausal and postmenopausal women, but its efficacy needs to be further affirmed.http://dx.doi.org/10.1155/2019/5151678 |
| spellingShingle | Tingting Bao Liuting Zeng Kailin Yang Yuehua Li Fengying Ren Yulong Zhang Ziren Gao Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis International Journal of Endocrinology |
| title | Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis |
| title_full | Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis |
| title_fullStr | Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis |
| title_full_unstemmed | Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis |
| title_short | Can Melatonin Improve the Osteopenia of Perimenopausal and Postmenopausal Women? A Meta-Analysis |
| title_sort | can melatonin improve the osteopenia of perimenopausal and postmenopausal women a meta analysis |
| url | http://dx.doi.org/10.1155/2019/5151678 |
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