Is L-carnitine protective in hypoxic cerebral edema in newborn mice?
The value of carnitine in the prevention of cerebral edema due to acute severe hypoxia in 38 newborn mice was studied. Twenty-nine animals received normal saline (0.25 ml) or carnitine (16 mmol/kg) intraperitoneally, thirty minutes before exposure to 0% oxygen in inspired air for two minutes....
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| Main Authors: | , , |
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| Format: | Article |
| Language: | English |
| Published: |
Hacettepe University Institute of Child Health
1993-10-01
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| Series: | The Turkish Journal of Pediatrics |
| Online Access: | https://turkjpediatr.org/article/view/3694 |
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| _version_ | 1850028818839896064 |
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| author | M Yurdakök R Haziroğlu T Coşkun |
| author_facet | M Yurdakök R Haziroğlu T Coşkun |
| author_sort | M Yurdakök |
| collection | DOAJ |
| description |
The value of carnitine in the prevention of cerebral edema due to acute severe hypoxia in 38 newborn mice was studied. Twenty-nine animals received normal saline (0.25 ml) or carnitine (16 mmol/kg) intraperitoneally, thirty minutes before exposure to 0% oxygen in inspired air for two minutes. Nine mice received no drug and were exposed to room air. After hypoxic insult, brain water content was measured and was found to be similar in all groups. These findings suggest that carnitine pretreatment does not prevent brain edema associated with cerebral hypoxia in newborn mice.
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| format | Article |
| id | doaj-art-d76255aef5ae49c4bb080c8f6bfc2962 |
| institution | DOAJ |
| issn | 0041-4301 2791-6421 |
| language | English |
| publishDate | 1993-10-01 |
| publisher | Hacettepe University Institute of Child Health |
| record_format | Article |
| series | The Turkish Journal of Pediatrics |
| spelling | doaj-art-d76255aef5ae49c4bb080c8f6bfc29622025-08-20T02:59:42ZengHacettepe University Institute of Child HealthThe Turkish Journal of Pediatrics0041-43012791-64211993-10-01354Is L-carnitine protective in hypoxic cerebral edema in newborn mice?M Yurdakök0R HaziroğluT CoşkunDepartment of Pediatrics, Hacettepe University Faculty of Medicine, Ankara. The value of carnitine in the prevention of cerebral edema due to acute severe hypoxia in 38 newborn mice was studied. Twenty-nine animals received normal saline (0.25 ml) or carnitine (16 mmol/kg) intraperitoneally, thirty minutes before exposure to 0% oxygen in inspired air for two minutes. Nine mice received no drug and were exposed to room air. After hypoxic insult, brain water content was measured and was found to be similar in all groups. These findings suggest that carnitine pretreatment does not prevent brain edema associated with cerebral hypoxia in newborn mice. https://turkjpediatr.org/article/view/3694 |
| spellingShingle | M Yurdakök R Haziroğlu T Coşkun Is L-carnitine protective in hypoxic cerebral edema in newborn mice? The Turkish Journal of Pediatrics |
| title | Is L-carnitine protective in hypoxic cerebral edema in newborn mice? |
| title_full | Is L-carnitine protective in hypoxic cerebral edema in newborn mice? |
| title_fullStr | Is L-carnitine protective in hypoxic cerebral edema in newborn mice? |
| title_full_unstemmed | Is L-carnitine protective in hypoxic cerebral edema in newborn mice? |
| title_short | Is L-carnitine protective in hypoxic cerebral edema in newborn mice? |
| title_sort | is l carnitine protective in hypoxic cerebral edema in newborn mice |
| url | https://turkjpediatr.org/article/view/3694 |
| work_keys_str_mv | AT myurdakok islcarnitineprotectiveinhypoxiccerebraledemainnewbornmice AT rhaziroglu islcarnitineprotectiveinhypoxiccerebraledemainnewbornmice AT tcoskun islcarnitineprotectiveinhypoxiccerebraledemainnewbornmice |