Association between serum magnesium concentrations and the risk of developing acute kidney injury in patients with cirrhosis: a retrospective cohort study based on the MIMIC-IV database
Background In various disease contexts, magnesium abnormalities are associated with acute kidney injury (AKI) incidence. However, this association remains unclear and has not been systematically investigated in patients with cirrhosis. Hence, we aimed to elucidate the association between admission s...
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2024-12-01
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| Series: | Renal Failure |
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| Online Access: | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2368088 |
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| author | Bingwen Lin Wenbiao Xiao Peng Huang Xinxin Lin Yuanxi Lin Jiandong Lin Xiongjian Xiao |
| author_facet | Bingwen Lin Wenbiao Xiao Peng Huang Xinxin Lin Yuanxi Lin Jiandong Lin Xiongjian Xiao |
| author_sort | Bingwen Lin |
| collection | DOAJ |
| description | Background In various disease contexts, magnesium abnormalities are associated with acute kidney injury (AKI) incidence. However, this association remains unclear and has not been systematically investigated in patients with cirrhosis. Hence, we aimed to elucidate the association between admission serum magnesium levels and AKI incidence in intensive care unit (ICU)-admitted cirrhotic patients.Methods A retrospective cohort study was conducted using MIMIC-IV2.2 data, focusing on critically ill patients with cirrhosis. We employed univariable and multivariable logistic regression and restricted cubic spline analyses to robustly address our research objectives. To further substantiate the findings, subgroup and sensitivity analyses were also conducted.Results Among the 3,228 enrolled ICU-admitted cirrhotic patients, 34.4% were female, and the overall AKI incidence was 68.6% (2,213/3,228). Multivariable logistic regression analysis revealed an independent relationship between elevated serum magnesium levels and increased AKI risk (OR = 1.55 [95% CI = 1.15–2.09], p = 0.004). Compared with individuals with serum magnesium levels < 1.6 mg/dL, individuals with serum magnesium levels in Q2 (1.6–2.6 mg/dL) and Q3 (≥2.6 mg/dL) had adjusted ORs for AKI of 1.89 (95% CI = 1.34–2.65, p < 0.001) and 2.19 (95% CI = 1.27–3.75, p = 0.005), respectively. The restricted cubic spline analysis revealed that AKI risk increased linearly with increasing serum magnesium levels. Subgroup analysis revealed that the association between serum magnesium levels and AKI incidence was remarkably stable in subgroup analysis (all Pinteraction >0.05).Conclusions High serum magnesium concentrations were significantly associated with an increased AKI risk in ICU-admitted patients with cirrhosis. Further randomized trials are needed to confirm this association. |
| format | Article |
| id | doaj-art-d759e4ad44524514b6674458bdb36dac |
| institution | DOAJ |
| issn | 0886-022X 1525-6049 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Renal Failure |
| spelling | doaj-art-d759e4ad44524514b6674458bdb36dac2025-08-20T03:21:40ZengTaylor & Francis GroupRenal Failure0886-022X1525-60492024-12-0146210.1080/0886022X.2024.2368088Association between serum magnesium concentrations and the risk of developing acute kidney injury in patients with cirrhosis: a retrospective cohort study based on the MIMIC-IV databaseBingwen Lin0Wenbiao Xiao1Peng Huang2Xinxin Lin3Yuanxi Lin4Jiandong Lin5Xiongjian Xiao6Department of Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Critical Care Medicine, The First Affiliated Hospital of Fujian Medical University, Fuzhou, ChinaDepartment of Critical Care Medicine, National Regional Medical Center, Binhai Campus of the First Affiliated Hospital, Fujian Medical University, Fuzhou, ChinaBackground In various disease contexts, magnesium abnormalities are associated with acute kidney injury (AKI) incidence. However, this association remains unclear and has not been systematically investigated in patients with cirrhosis. Hence, we aimed to elucidate the association between admission serum magnesium levels and AKI incidence in intensive care unit (ICU)-admitted cirrhotic patients.Methods A retrospective cohort study was conducted using MIMIC-IV2.2 data, focusing on critically ill patients with cirrhosis. We employed univariable and multivariable logistic regression and restricted cubic spline analyses to robustly address our research objectives. To further substantiate the findings, subgroup and sensitivity analyses were also conducted.Results Among the 3,228 enrolled ICU-admitted cirrhotic patients, 34.4% were female, and the overall AKI incidence was 68.6% (2,213/3,228). Multivariable logistic regression analysis revealed an independent relationship between elevated serum magnesium levels and increased AKI risk (OR = 1.55 [95% CI = 1.15–2.09], p = 0.004). Compared with individuals with serum magnesium levels < 1.6 mg/dL, individuals with serum magnesium levels in Q2 (1.6–2.6 mg/dL) and Q3 (≥2.6 mg/dL) had adjusted ORs for AKI of 1.89 (95% CI = 1.34–2.65, p < 0.001) and 2.19 (95% CI = 1.27–3.75, p = 0.005), respectively. The restricted cubic spline analysis revealed that AKI risk increased linearly with increasing serum magnesium levels. Subgroup analysis revealed that the association between serum magnesium levels and AKI incidence was remarkably stable in subgroup analysis (all Pinteraction >0.05).Conclusions High serum magnesium concentrations were significantly associated with an increased AKI risk in ICU-admitted patients with cirrhosis. Further randomized trials are needed to confirm this association.https://www.tandfonline.com/doi/10.1080/0886022X.2024.2368088Cirrhosisacute kidney injurymagnesiumintensive care unit |
| spellingShingle | Bingwen Lin Wenbiao Xiao Peng Huang Xinxin Lin Yuanxi Lin Jiandong Lin Xiongjian Xiao Association between serum magnesium concentrations and the risk of developing acute kidney injury in patients with cirrhosis: a retrospective cohort study based on the MIMIC-IV database Renal Failure Cirrhosis acute kidney injury magnesium intensive care unit |
| title | Association between serum magnesium concentrations and the risk of developing acute kidney injury in patients with cirrhosis: a retrospective cohort study based on the MIMIC-IV database |
| title_full | Association between serum magnesium concentrations and the risk of developing acute kidney injury in patients with cirrhosis: a retrospective cohort study based on the MIMIC-IV database |
| title_fullStr | Association between serum magnesium concentrations and the risk of developing acute kidney injury in patients with cirrhosis: a retrospective cohort study based on the MIMIC-IV database |
| title_full_unstemmed | Association between serum magnesium concentrations and the risk of developing acute kidney injury in patients with cirrhosis: a retrospective cohort study based on the MIMIC-IV database |
| title_short | Association between serum magnesium concentrations and the risk of developing acute kidney injury in patients with cirrhosis: a retrospective cohort study based on the MIMIC-IV database |
| title_sort | association between serum magnesium concentrations and the risk of developing acute kidney injury in patients with cirrhosis a retrospective cohort study based on the mimic iv database |
| topic | Cirrhosis acute kidney injury magnesium intensive care unit |
| url | https://www.tandfonline.com/doi/10.1080/0886022X.2024.2368088 |
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