Treatment Results of Extracranial Malignant Germ Cell Tumor with Regimens of Cisplatin, Vinblastine, Bleomycin or Carboplatin, Etoposide, and Bleomycin with Special Emphasis on the Sites of Vagina and Testis
The survival of children with malignant germ cell tumor (GCT) increased over the past 2 decades with platinum-based chemotherapy. This report has three objectives: (1) comparison of PVB (cisplatin, vinblastine, and bleomycin) with JEB (carboplatin, etoposide, and bleomycin) regimens; (2) treatment m...
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| Format: | Article |
| Language: | English |
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Elsevier
2015-10-01
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| Series: | Pediatrics and Neonatology |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S1875957215000194 |
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| author | Jen-Yin Hou Hsi-Che Liu Ting-Chi Yeh Jin-Cherng Sheu Kuan-Hao Chen Ching-Yi Chang Der-Cherng Liang |
| author_facet | Jen-Yin Hou Hsi-Che Liu Ting-Chi Yeh Jin-Cherng Sheu Kuan-Hao Chen Ching-Yi Chang Der-Cherng Liang |
| author_sort | Jen-Yin Hou |
| collection | DOAJ |
| description | The survival of children with malignant germ cell tumor (GCT) increased over the past 2 decades with platinum-based chemotherapy. This report has three objectives: (1) comparison of PVB (cisplatin, vinblastine, and bleomycin) with JEB (carboplatin, etoposide, and bleomycin) regimens; (2) treatment modality of vaginal GCT; and (3) management of stage I testicular yolk sac tumor (YST) in boys under 2 years old.
Methods: From January 1, 1987 to December 31, 2010, 81 patients with malignant extracranial GCT were treated. Two consecutive protocols, PVB followed by JEB, were used. Girls with vaginal YST received minimal surgery and chemotherapy. Boys under 2 years old with Stage I testicular YST received surgery with or without chemotherapy.
Results: As of June 30, 2012, the 10-year overall survival (OS) was 95 ± 3% (standard error) and the event-free survival (EFS) was 88 ± 4%. With PVB, 35 patients had 10-year OS of 91 ± 5% and EFS of 89 ± 5%. With JEB, 25 patients had 7-year OS of 96 ± 5% and EFS of 96 ± 5%. All five girls with vaginal YST were cured with vagina-preserved strategy. In 32 boys age under 2 years old with stage I YST, 16 with light chemotherapy were all in EFS, whereas two of 16 patients without chemotherapy relapsed. After PVB, six patients developed nephrotoxicity and one had pulmonary fibrosis.
Conclusion: Girls with vaginal YST who received minimal surgery and chemotherapy had excellent prognosis and sexual organs were preservable. Light chemotherapy after surgery is a treatment option for boys under 2 years old with stage I YST to decrease relapse rate. Both JEB and PVB are effective. JEB resulted in more myelosuppression but otherwise less serious long-term toxicity than PVB. |
| format | Article |
| id | doaj-art-d759bb1c1b4544bdab073a1783e1e2ba |
| institution | OA Journals |
| issn | 1875-9572 |
| language | English |
| publishDate | 2015-10-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Pediatrics and Neonatology |
| spelling | doaj-art-d759bb1c1b4544bdab073a1783e1e2ba2025-08-20T02:04:01ZengElsevierPediatrics and Neonatology1875-95722015-10-0156530130610.1016/j.pedneo.2014.12.003Treatment Results of Extracranial Malignant Germ Cell Tumor with Regimens of Cisplatin, Vinblastine, Bleomycin or Carboplatin, Etoposide, and Bleomycin with Special Emphasis on the Sites of Vagina and TestisJen-Yin Hou0Hsi-Che Liu1Ting-Chi Yeh2Jin-Cherng Sheu3Kuan-Hao Chen4Ching-Yi Chang5Der-Cherng Liang6Mackay Junior College of Medicine, Nursing and Management, Taipei, TaiwanDivision of Pediatric Hematology–Oncology, Mackay Memorial Hospital, Taipei, TaiwanDivision of Pediatric Hematology–Oncology, Mackay Memorial Hospital, Taipei, TaiwanDivision of Pediatric Surgery, Mackay Memorial Hospital, Taipei, TaiwanDivision of Pediatric Hematology–Oncology, Mackay Memorial Hospital, Taipei, TaiwanDivision of Pediatric Hematology–Oncology, Mackay Memorial Hospital, Taipei, TaiwanDivision of Pediatric Hematology–Oncology, Mackay Memorial Hospital, Taipei, TaiwanThe survival of children with malignant germ cell tumor (GCT) increased over the past 2 decades with platinum-based chemotherapy. This report has three objectives: (1) comparison of PVB (cisplatin, vinblastine, and bleomycin) with JEB (carboplatin, etoposide, and bleomycin) regimens; (2) treatment modality of vaginal GCT; and (3) management of stage I testicular yolk sac tumor (YST) in boys under 2 years old. Methods: From January 1, 1987 to December 31, 2010, 81 patients with malignant extracranial GCT were treated. Two consecutive protocols, PVB followed by JEB, were used. Girls with vaginal YST received minimal surgery and chemotherapy. Boys under 2 years old with Stage I testicular YST received surgery with or without chemotherapy. Results: As of June 30, 2012, the 10-year overall survival (OS) was 95 ± 3% (standard error) and the event-free survival (EFS) was 88 ± 4%. With PVB, 35 patients had 10-year OS of 91 ± 5% and EFS of 89 ± 5%. With JEB, 25 patients had 7-year OS of 96 ± 5% and EFS of 96 ± 5%. All five girls with vaginal YST were cured with vagina-preserved strategy. In 32 boys age under 2 years old with stage I YST, 16 with light chemotherapy were all in EFS, whereas two of 16 patients without chemotherapy relapsed. After PVB, six patients developed nephrotoxicity and one had pulmonary fibrosis. Conclusion: Girls with vaginal YST who received minimal surgery and chemotherapy had excellent prognosis and sexual organs were preservable. Light chemotherapy after surgery is a treatment option for boys under 2 years old with stage I YST to decrease relapse rate. Both JEB and PVB are effective. JEB resulted in more myelosuppression but otherwise less serious long-term toxicity than PVB.http://www.sciencedirect.com/science/article/pii/S1875957215000194childhoodgerm cell tumorstage I testes tumorvaginal tumoryolk sac tumor |
| spellingShingle | Jen-Yin Hou Hsi-Che Liu Ting-Chi Yeh Jin-Cherng Sheu Kuan-Hao Chen Ching-Yi Chang Der-Cherng Liang Treatment Results of Extracranial Malignant Germ Cell Tumor with Regimens of Cisplatin, Vinblastine, Bleomycin or Carboplatin, Etoposide, and Bleomycin with Special Emphasis on the Sites of Vagina and Testis Pediatrics and Neonatology childhood germ cell tumor stage I testes tumor vaginal tumor yolk sac tumor |
| title | Treatment Results of Extracranial Malignant Germ Cell Tumor with Regimens of Cisplatin, Vinblastine, Bleomycin or Carboplatin, Etoposide, and Bleomycin with Special Emphasis on the Sites of Vagina and Testis |
| title_full | Treatment Results of Extracranial Malignant Germ Cell Tumor with Regimens of Cisplatin, Vinblastine, Bleomycin or Carboplatin, Etoposide, and Bleomycin with Special Emphasis on the Sites of Vagina and Testis |
| title_fullStr | Treatment Results of Extracranial Malignant Germ Cell Tumor with Regimens of Cisplatin, Vinblastine, Bleomycin or Carboplatin, Etoposide, and Bleomycin with Special Emphasis on the Sites of Vagina and Testis |
| title_full_unstemmed | Treatment Results of Extracranial Malignant Germ Cell Tumor with Regimens of Cisplatin, Vinblastine, Bleomycin or Carboplatin, Etoposide, and Bleomycin with Special Emphasis on the Sites of Vagina and Testis |
| title_short | Treatment Results of Extracranial Malignant Germ Cell Tumor with Regimens of Cisplatin, Vinblastine, Bleomycin or Carboplatin, Etoposide, and Bleomycin with Special Emphasis on the Sites of Vagina and Testis |
| title_sort | treatment results of extracranial malignant germ cell tumor with regimens of cisplatin vinblastine bleomycin or carboplatin etoposide and bleomycin with special emphasis on the sites of vagina and testis |
| topic | childhood germ cell tumor stage I testes tumor vaginal tumor yolk sac tumor |
| url | http://www.sciencedirect.com/science/article/pii/S1875957215000194 |
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