Effect of valproic acid upon skeletal muscle subjected to prolonged tourniquet application

Background Valproic acid (VPA), a histone deacetylase inhibitor, has shown improved outcomes when used as a pharmaceutical intervention in animal studies of hemorrhage, septic shock, and combined injuries. This study was designed to investigate the ability of VPA to mitigate ischemia–reperfusion inj...

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Bibliographic Details
Main Authors: Robert Moritz, Lee Mangum, Chet Voelker, Gerardo Garcia, Joseph Wenke
Format: Article
Language:English
Published: BMJ Publishing Group 2023-12-01
Series:Trauma Surgery & Acute Care Open
Online Access:https://tsaco.bmj.com/content/8/1/e001074.full
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