Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis

Integration of GWAS, QTLs and keratinocyte functional assays reveals molecular mechanisms of atopic dermatitis

Abstract Atopic dermatitis is a highly heritable and common inflammatory skin condition affecting children and adults worldwide. Multi-ancestry approaches to atopic dermatitis genetic association studies are poised to boost power to detect genetic signal and identify loci contributing to atopic derm...

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Main Authors: Meritxell Oliva, Mrinal K. Sarkar, Michael E. March, Amir Hossein Saeidian, Frank D. Mentch, Chen-Lin Hsieh, Fanying Tang, Ranjitha Uppala, Matthew T. Patrick, Qinmengge Li, Rachael Bogle, J. Michelle Kahlenberg, Deborah Watson, Joseph T. Glessner, Leila Youssefian, Hassan Vahidnezhad, Lam C. Tsoi, Hakon Hakonarson, Johann E. Gudjonsson, Kathleen M. Smith, Bridget Riley-Gillis
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-025-58310-7
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