Delayed neoadjuvant therapeutic response in rare giant pulmonary tumor: A case report
Primary pulmonary synovial sarcoma (PPSS) is an extremely rare intrathoracic soft tissue sarcoma, but there remains a notable absence of consensus guidelines for the diagnosis and treatment of these tumors. In this case, we reported a 35-year-old PPSS patient who received neoadjuvant chemotherapy co...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-01-01
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| Series: | Respiratory Medicine Case Reports |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2213007125001066 |
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| author | Kai Zhang Yuanyuan Wang Yi Li |
| author_facet | Kai Zhang Yuanyuan Wang Yi Li |
| author_sort | Kai Zhang |
| collection | DOAJ |
| description | Primary pulmonary synovial sarcoma (PPSS) is an extremely rare intrathoracic soft tissue sarcoma, but there remains a notable absence of consensus guidelines for the diagnosis and treatment of these tumors. In this case, we reported a 35-year-old PPSS patient who received neoadjuvant chemotherapy consisting of adriamycin and ifosfamide combined with anlotinib, a multi-target tyrosine kinase inhibitor. Although initial response assessment was not encouraging, subsequent imaging studies revealed therapeutic efficacy. This case underscores the critical role of multidisciplinary team and neoadjuvant therapy in PPSS management, aiming to raise awareness of this rare malignancy. |
| format | Article |
| id | doaj-art-d751741f2efb4181bfde8d9c58b93a42 |
| institution | Kabale University |
| issn | 2213-0071 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Respiratory Medicine Case Reports |
| spelling | doaj-art-d751741f2efb4181bfde8d9c58b93a422025-08-20T03:58:41ZengElsevierRespiratory Medicine Case Reports2213-00712025-01-015710227010.1016/j.rmcr.2025.102270Delayed neoadjuvant therapeutic response in rare giant pulmonary tumor: A case reportKai Zhang0Yuanyuan Wang1Yi Li2Department of Oncology, 920th Hospital of Joint Logistics Support Force, Kunming, ChinaDepartment of Pathology, 920th Hospital of Joint Logistics Support Force, Kunming, ChinaDepartment of Oncology, 920th Hospital of Joint Logistics Support Force, Kunming, China; Corresponding author.Primary pulmonary synovial sarcoma (PPSS) is an extremely rare intrathoracic soft tissue sarcoma, but there remains a notable absence of consensus guidelines for the diagnosis and treatment of these tumors. In this case, we reported a 35-year-old PPSS patient who received neoadjuvant chemotherapy consisting of adriamycin and ifosfamide combined with anlotinib, a multi-target tyrosine kinase inhibitor. Although initial response assessment was not encouraging, subsequent imaging studies revealed therapeutic efficacy. This case underscores the critical role of multidisciplinary team and neoadjuvant therapy in PPSS management, aiming to raise awareness of this rare malignancy.http://www.sciencedirect.com/science/article/pii/S2213007125001066 |
| spellingShingle | Kai Zhang Yuanyuan Wang Yi Li Delayed neoadjuvant therapeutic response in rare giant pulmonary tumor: A case report Respiratory Medicine Case Reports |
| title | Delayed neoadjuvant therapeutic response in rare giant pulmonary tumor: A case report |
| title_full | Delayed neoadjuvant therapeutic response in rare giant pulmonary tumor: A case report |
| title_fullStr | Delayed neoadjuvant therapeutic response in rare giant pulmonary tumor: A case report |
| title_full_unstemmed | Delayed neoadjuvant therapeutic response in rare giant pulmonary tumor: A case report |
| title_short | Delayed neoadjuvant therapeutic response in rare giant pulmonary tumor: A case report |
| title_sort | delayed neoadjuvant therapeutic response in rare giant pulmonary tumor a case report |
| url | http://www.sciencedirect.com/science/article/pii/S2213007125001066 |
| work_keys_str_mv | AT kaizhang delayedneoadjuvanttherapeuticresponseinraregiantpulmonarytumoracasereport AT yuanyuanwang delayedneoadjuvanttherapeuticresponseinraregiantpulmonarytumoracasereport AT yili delayedneoadjuvanttherapeuticresponseinraregiantpulmonarytumoracasereport |