Cigarette smoking and alcohol-related liver disease
China is a major consumer of alcohol and tobacco. Tobacco and alcohol use are closely linked, with up to 90% of alcoholics having a history of tobacco use, and heavy smokers also tending to be alcoholics. Alcohol-related liver disease (ALD), one of the most common and serious complications of chroni...
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| Format: | Article |
| Language: | English |
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KeAi Communications Co., Ltd.
2024-12-01
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| Series: | Liver Research |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2542568424000692 |
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| author | Hui-Min Lin Jing-Rong Zhang Meng-Xue Li Hui Hou Hua Wang Yan Huang |
| author_facet | Hui-Min Lin Jing-Rong Zhang Meng-Xue Li Hui Hou Hua Wang Yan Huang |
| author_sort | Hui-Min Lin |
| collection | DOAJ |
| description | China is a major consumer of alcohol and tobacco. Tobacco and alcohol use are closely linked, with up to 90% of alcoholics having a history of tobacco use, and heavy smokers also tending to be alcoholics. Alcohol-related liver disease (ALD), one of the most common and serious complications of chronic alcohol intake, involving hepatic steatosis, hepatitis, hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC), has become one of the globally prevalent chronic diseases. An increasing number of studies have focused on the association between smoking and ALD and explored the mechanisms involved. Clinical evidence suggests that smoking has a negative impact on the incidence and severity of fatty liver disease, progression of liver fibrosis, development of HCC, prognosis of patients with advanced liver disease, and alcohol-related liver transplant recipients. The underlying mechanisms are complex and involve different pathophysiological pathways, including free radical exposure, endoplasmic reticulum stress, insulin resistance, and oncogenic signaling. This review discusses the deleterious effects of smoking on ALD patients and the possible underlying mechanisms at several levels. It emphasizes the importance of discouraging smoking among ALD patients. Finally, the pathogenic role of electronic cigarettes, which have emerged in recent years, is discussed, calling for an emphasis on social missions for young people. |
| format | Article |
| id | doaj-art-d74fb335947d48298db6e94b726f3f78 |
| institution | DOAJ |
| issn | 2542-5684 |
| language | English |
| publishDate | 2024-12-01 |
| publisher | KeAi Communications Co., Ltd. |
| record_format | Article |
| series | Liver Research |
| spelling | doaj-art-d74fb335947d48298db6e94b726f3f782025-08-20T02:57:24ZengKeAi Communications Co., Ltd.Liver Research2542-56842024-12-018423724510.1016/j.livres.2024.12.002Cigarette smoking and alcohol-related liver diseaseHui-Min Lin0Jing-Rong Zhang1Meng-Xue Li2Hui Hou3Hua Wang4Yan Huang5Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China; Department of Pharmacy, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, ChinaAnhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, ChinaAnhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, ChinaDepartment of Pharmacy, The Second Affiliated Hospital of Anhui Medical University, Hefei, Anhui, China; Corresponding author.Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China; Corresponding author.Anhui Provincial Laboratory of Inflammatory and Immunity Disease, Anhui Institute of Innovative Drugs, School of Pharmacy, Anhui Medical University, Hefei, Anhui, China; Corresponding author.China is a major consumer of alcohol and tobacco. Tobacco and alcohol use are closely linked, with up to 90% of alcoholics having a history of tobacco use, and heavy smokers also tending to be alcoholics. Alcohol-related liver disease (ALD), one of the most common and serious complications of chronic alcohol intake, involving hepatic steatosis, hepatitis, hepatic fibrosis, cirrhosis and hepatocellular carcinoma (HCC), has become one of the globally prevalent chronic diseases. An increasing number of studies have focused on the association between smoking and ALD and explored the mechanisms involved. Clinical evidence suggests that smoking has a negative impact on the incidence and severity of fatty liver disease, progression of liver fibrosis, development of HCC, prognosis of patients with advanced liver disease, and alcohol-related liver transplant recipients. The underlying mechanisms are complex and involve different pathophysiological pathways, including free radical exposure, endoplasmic reticulum stress, insulin resistance, and oncogenic signaling. This review discusses the deleterious effects of smoking on ALD patients and the possible underlying mechanisms at several levels. It emphasizes the importance of discouraging smoking among ALD patients. Finally, the pathogenic role of electronic cigarettes, which have emerged in recent years, is discussed, calling for an emphasis on social missions for young people.http://www.sciencedirect.com/science/article/pii/S2542568424000692Cigarette smoking (CS)Alcohol-related liver disease (ALD)Electronic cigarettes (E-cigarettes)AlcoholismLiver transplantation (LT) |
| spellingShingle | Hui-Min Lin Jing-Rong Zhang Meng-Xue Li Hui Hou Hua Wang Yan Huang Cigarette smoking and alcohol-related liver disease Liver Research Cigarette smoking (CS) Alcohol-related liver disease (ALD) Electronic cigarettes (E-cigarettes) Alcoholism Liver transplantation (LT) |
| title | Cigarette smoking and alcohol-related liver disease |
| title_full | Cigarette smoking and alcohol-related liver disease |
| title_fullStr | Cigarette smoking and alcohol-related liver disease |
| title_full_unstemmed | Cigarette smoking and alcohol-related liver disease |
| title_short | Cigarette smoking and alcohol-related liver disease |
| title_sort | cigarette smoking and alcohol related liver disease |
| topic | Cigarette smoking (CS) Alcohol-related liver disease (ALD) Electronic cigarettes (E-cigarettes) Alcoholism Liver transplantation (LT) |
| url | http://www.sciencedirect.com/science/article/pii/S2542568424000692 |
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