Low irisin levels are associated with increased body weight and an adverse metabolic profile
Abstract Objective: To assess whether plasma irisin is associated with anthropometric, body composition, and metabolic parameters according to body mass index. Methods: A prospective cohort study was conducted at a tertiary referral hospital in Southern Brazil. Patients were divided according to b...
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Brazilian Society of Endocrinology and Metabolism
2025-08-01
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| Series: | Archives of Endocrinology and Metabolism |
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| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000301102&lng=en&tlng=en |
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| author | Milene Moehlecke Jakeline Rheinheimer Daisy Crispim Manoel Roberto Maciel Trindade Cristiane Bauermann Leitão |
| author_facet | Milene Moehlecke Jakeline Rheinheimer Daisy Crispim Manoel Roberto Maciel Trindade Cristiane Bauermann Leitão |
| author_sort | Milene Moehlecke |
| collection | DOAJ |
| description | Abstract Objective: To assess whether plasma irisin is associated with anthropometric, body composition, and metabolic parameters according to body mass index. Methods: A prospective cohort study was conducted at a tertiary referral hospital in Southern Brazil. Patients were divided according to body mass index: Group 1 (body mass index = 18.5 - 29.9 kg/m2; n = 15), Group 2 (body mass index = 30 - 39.9 kg/m2; n = 36), and Group 3 (body mass index ≥ 40 kg/m2; n = 30). Groups 1 and 2 underwent cholecystectomy, while Group 3 underwent Roux-en-Y gastric bypass. All groups were evaluated at baseline, and Groups 2 and 3 were re-evaluated 6 months later. Body composition was assessed using X-ray absorptiometry, and resting energy expenditure was measured by indirect calorimetry. Results: The study subjects were predominantly female (75%), white (82%), with a mean age of 46 ± 14 years. Group 3 had lower irisin levels compared to Group 2: 9.1 ± 2.2 versus 10.7 ± 2.8 ng/mL; p = 0.038). Irisin was negatively correlated with weight (r = -0.246; p = 0.042), waist circumference (r = -0.272; p = 0.024), glucose (r = -0.259; p = 0.039), glycated hemoglobin (r = -0.283; p = 0.024), triglycerides (r = -0.414; p = 0.024), and positively correlated with HDL (r = 0.280; p = 0.029). Conclusion: Irisin showed an inverse correlation with insulin-related metabolic pathways, suggesting its potential involvement in insulin resistance states such as obesity and type 2 diabetes. |
| format | Article |
| id | doaj-art-d74d19304f97444e89bd8cd4a81ec84c |
| institution | DOAJ |
| issn | 2359-4292 |
| language | English |
| publishDate | 2025-08-01 |
| publisher | Brazilian Society of Endocrinology and Metabolism |
| record_format | Article |
| series | Archives of Endocrinology and Metabolism |
| spelling | doaj-art-d74d19304f97444e89bd8cd4a81ec84c2025-08-20T03:23:26ZengBrazilian Society of Endocrinology and MetabolismArchives of Endocrinology and Metabolism2359-42922025-08-0169310.20945/2359-4292-2024-0441Low irisin levels are associated with increased body weight and an adverse metabolic profileMilene Moehleckehttps://orcid.org/0000-0002-4237-206XJakeline Rheinheimerhttps://orcid.org/0009-0007-1892-7831Daisy Crispimhttps://orcid.org/0000-0001-5095-9269Manoel Roberto Maciel Trindadehttps://orcid.org/0000-0001-7809-8296Cristiane Bauermann Leitãohttps://orcid.org/0000-0002-2106-309XAbstract Objective: To assess whether plasma irisin is associated with anthropometric, body composition, and metabolic parameters according to body mass index. Methods: A prospective cohort study was conducted at a tertiary referral hospital in Southern Brazil. Patients were divided according to body mass index: Group 1 (body mass index = 18.5 - 29.9 kg/m2; n = 15), Group 2 (body mass index = 30 - 39.9 kg/m2; n = 36), and Group 3 (body mass index ≥ 40 kg/m2; n = 30). Groups 1 and 2 underwent cholecystectomy, while Group 3 underwent Roux-en-Y gastric bypass. All groups were evaluated at baseline, and Groups 2 and 3 were re-evaluated 6 months later. Body composition was assessed using X-ray absorptiometry, and resting energy expenditure was measured by indirect calorimetry. Results: The study subjects were predominantly female (75%), white (82%), with a mean age of 46 ± 14 years. Group 3 had lower irisin levels compared to Group 2: 9.1 ± 2.2 versus 10.7 ± 2.8 ng/mL; p = 0.038). Irisin was negatively correlated with weight (r = -0.246; p = 0.042), waist circumference (r = -0.272; p = 0.024), glucose (r = -0.259; p = 0.039), glycated hemoglobin (r = -0.283; p = 0.024), triglycerides (r = -0.414; p = 0.024), and positively correlated with HDL (r = 0.280; p = 0.029). Conclusion: Irisin showed an inverse correlation with insulin-related metabolic pathways, suggesting its potential involvement in insulin resistance states such as obesity and type 2 diabetes.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000301102&lng=en&tlng=enBody mass indexObesityMetabolic diseasesDiabetes mellitustype 2 |
| spellingShingle | Milene Moehlecke Jakeline Rheinheimer Daisy Crispim Manoel Roberto Maciel Trindade Cristiane Bauermann Leitão Low irisin levels are associated with increased body weight and an adverse metabolic profile Archives of Endocrinology and Metabolism Body mass index Obesity Metabolic diseases Diabetes mellitus type 2 |
| title | Low irisin levels are associated with increased body weight and an adverse metabolic profile |
| title_full | Low irisin levels are associated with increased body weight and an adverse metabolic profile |
| title_fullStr | Low irisin levels are associated with increased body weight and an adverse metabolic profile |
| title_full_unstemmed | Low irisin levels are associated with increased body weight and an adverse metabolic profile |
| title_short | Low irisin levels are associated with increased body weight and an adverse metabolic profile |
| title_sort | low irisin levels are associated with increased body weight and an adverse metabolic profile |
| topic | Body mass index Obesity Metabolic diseases Diabetes mellitus type 2 |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S2359-39972025000301102&lng=en&tlng=en |
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