Molecular mechanisms of regulation of erythropoiesis and stress erythropoiesis
Erythropoiesis under basal conditions involves the continuous production of new erythrocytes at a constant rate. During the adult period, erythropoiesis takes place primarily in the bone marrow and has a substantial capacity. The regulation of this process is achieved through a multitude of cellular...
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University of Belgrade, Medical Faculty
2024-01-01
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| Series: | Medicinski Podmladak |
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| Online Access: | https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2024/0369-15272406017M.pdf |
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| author | Momčilović Sanja Bogdanović Andrija Vignjević-Petrinović Sanja |
| author_facet | Momčilović Sanja Bogdanović Andrija Vignjević-Petrinović Sanja |
| author_sort | Momčilović Sanja |
| collection | DOAJ |
| description | Erythropoiesis under basal conditions involves the continuous production of new erythrocytes at a constant rate. During the adult period, erythropoiesis takes place primarily in the bone marrow and has a substantial capacity. The regulation of this process is achieved through a multitude of cellular and molecular mechanisms that synergistically act to ensure adequate tissue oxygenation while avoiding viscosity-related issues associated with excessive production. Therefore, this process is regulated through both positive and negative feedback mechanisms. In contrast to the continuous renewal of erythrocytes under basal conditions, disruptions in homeostasis such as bleeding, stress, inflammation, etc., lead to the activation of a process known as stress erythropoiesis. Stress erythropoiesis is a unique process that, in addition to the bone marrow, also occurs extramedullary. Extramedullary erythropoiesis primarily takes place in the red pulp of the spleen, where, under the influence of specific signals within its microenvironment, there is an extensive expansion of immature erythroid cell populations. This process ensures an adequate response to the increased demands for erythropoiesis. This paper elucidates the fundamental molecular mechanisms involved in regulating erythropoiesis under basal conditions and stress erythropoiesis. It highlights the dependency of these molecular mechanisms on the microenvironment in which these processes occur. Understanding the molecular mechanisms that govern erythropoiesis and stress erythropoiesis is crucial for advancing therapeutic strategies for hematological disorders. |
| format | Article |
| id | doaj-art-d74bd1e4d612476b973e35b0db3acf57 |
| institution | OA Journals |
| issn | 0369-1527 2466-5525 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | University of Belgrade, Medical Faculty |
| record_format | Article |
| series | Medicinski Podmladak |
| spelling | doaj-art-d74bd1e4d612476b973e35b0db3acf572025-08-20T02:25:04ZengUniversity of Belgrade, Medical FacultyMedicinski Podmladak0369-15272466-55252024-01-01756172310.5937/mp75-476800369-15272406017MMolecular mechanisms of regulation of erythropoiesis and stress erythropoiesisMomčilović Sanja0Bogdanović Andrija1https://orcid.org/0000-0002-8288-7308Vignjević-Petrinović Sanja2Univerzitet u Beogradu, Medicinski fakultet, Beograd, SerbiaUniverzitet u Beogradu, Medicinski fakultet, Beograd, SerbiaUniverzitet u Beogradu, Institut za medicinska istraživanja, Institut od nacionalnog značaja za Republiku Srbiju, Beograd, SerbiaErythropoiesis under basal conditions involves the continuous production of new erythrocytes at a constant rate. During the adult period, erythropoiesis takes place primarily in the bone marrow and has a substantial capacity. The regulation of this process is achieved through a multitude of cellular and molecular mechanisms that synergistically act to ensure adequate tissue oxygenation while avoiding viscosity-related issues associated with excessive production. Therefore, this process is regulated through both positive and negative feedback mechanisms. In contrast to the continuous renewal of erythrocytes under basal conditions, disruptions in homeostasis such as bleeding, stress, inflammation, etc., lead to the activation of a process known as stress erythropoiesis. Stress erythropoiesis is a unique process that, in addition to the bone marrow, also occurs extramedullary. Extramedullary erythropoiesis primarily takes place in the red pulp of the spleen, where, under the influence of specific signals within its microenvironment, there is an extensive expansion of immature erythroid cell populations. This process ensures an adequate response to the increased demands for erythropoiesis. This paper elucidates the fundamental molecular mechanisms involved in regulating erythropoiesis under basal conditions and stress erythropoiesis. It highlights the dependency of these molecular mechanisms on the microenvironment in which these processes occur. Understanding the molecular mechanisms that govern erythropoiesis and stress erythropoiesis is crucial for advancing therapeutic strategies for hematological disorders.https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2024/0369-15272406017M.pdfmolecular mechanismserythropoiesisstress erythropoiesis |
| spellingShingle | Momčilović Sanja Bogdanović Andrija Vignjević-Petrinović Sanja Molecular mechanisms of regulation of erythropoiesis and stress erythropoiesis Medicinski Podmladak molecular mechanisms erythropoiesis stress erythropoiesis |
| title | Molecular mechanisms of regulation of erythropoiesis and stress erythropoiesis |
| title_full | Molecular mechanisms of regulation of erythropoiesis and stress erythropoiesis |
| title_fullStr | Molecular mechanisms of regulation of erythropoiesis and stress erythropoiesis |
| title_full_unstemmed | Molecular mechanisms of regulation of erythropoiesis and stress erythropoiesis |
| title_short | Molecular mechanisms of regulation of erythropoiesis and stress erythropoiesis |
| title_sort | molecular mechanisms of regulation of erythropoiesis and stress erythropoiesis |
| topic | molecular mechanisms erythropoiesis stress erythropoiesis |
| url | https://scindeks-clanci.ceon.rs/data/pdf/0369-1527/2024/0369-15272406017M.pdf |
| work_keys_str_mv | AT momcilovicsanja molecularmechanismsofregulationoferythropoiesisandstresserythropoiesis AT bogdanovicandrija molecularmechanismsofregulationoferythropoiesisandstresserythropoiesis AT vignjevicpetrinovicsanja molecularmechanismsofregulationoferythropoiesisandstresserythropoiesis |