Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes
Abstract Background Cardiac autonomic neuropathy (CAN) is a life-threatening complication of diabetes. While obesity is a well-known risk factor of dysautonomia, the association between CAN and body fat distribution has not been fully clarified, especially in autoimmune diabetes (AD). Aim To evaluat...
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| Format: | Article |
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BMC
2025-02-01
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| Series: | Cardiovascular Diabetology |
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| Online Access: | https://doi.org/10.1186/s12933-025-02635-6 |
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| author | Renata Risi Rocco Amendolara Angelo Lauria Pantano Valeria Fassino Luca D’Onofrio Lucia Coraggio Daniela Luverà Davide Masi Mikiko Watanabe Lucio Gnessi Raffaella Buzzetti Ernesto Maddaloni |
| author_facet | Renata Risi Rocco Amendolara Angelo Lauria Pantano Valeria Fassino Luca D’Onofrio Lucia Coraggio Daniela Luverà Davide Masi Mikiko Watanabe Lucio Gnessi Raffaella Buzzetti Ernesto Maddaloni |
| author_sort | Renata Risi |
| collection | DOAJ |
| description | Abstract Background Cardiac autonomic neuropathy (CAN) is a life-threatening complication of diabetes. While obesity is a well-known risk factor of dysautonomia, the association between CAN and body fat distribution has not been fully clarified, especially in autoimmune diabetes (AD). Aim To evaluate if the association between CAN and body fat distribution differs between AD and type 2 diabetes (T2D). Methods Body fat distribution was evaluated by Dual X-Ray Absorptiometry in 143 people with diabetes (44 with ADand 99 with T2D) undergoing clinical screening for CAN. The association of CAN with markers of ectopic fat distribution was evaluated in multivariate regression models adjusting for confounders and testing for the interaction between diabetes type and CAN. Results A significant interaction between CAN and diabetes type was found with respect to markers of ectopic fat distribution. Specifically, people with CAN had significantly higher amount of visceral adipose tissue (530 [376–665]g versus 251[189–360]g, p = 0.001), total fat mass (22708[20200–27845]g versus 15434[12981–21879]g, p = 0,016), and trunk-to-leg ratio (0.88 [0.75–1.04] versus 0.70 [0.56–0.78], p = 0,023) compared to those without CAN only in participants with AD, but not in T2D (p-values for interaction < 0.05 for all comparisons). Conclusion Ectopic fat distribution is more strongly associated with CAN in AD than in T2D. This highlights the distinct role of fat distribution in the cardiometabolic health of people with AD, suggesting the need for further studies to better understand the pathophysiology and implications of overweight in this population. |
| format | Article |
| id | doaj-art-d74aa763bae04324bc22f6f326a16db2 |
| institution | Kabale University |
| issn | 1475-2840 |
| language | English |
| publishDate | 2025-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj-art-d74aa763bae04324bc22f6f326a16db22025-08-24T11:06:24ZengBMCCardiovascular Diabetology1475-28402025-02-012411810.1186/s12933-025-02635-6Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetesRenata Risi0Rocco Amendolara1Angelo Lauria Pantano2Valeria Fassino3Luca D’Onofrio4Lucia Coraggio5Daniela Luverà6Davide Masi7Mikiko Watanabe8Lucio Gnessi9Raffaella Buzzetti10Ernesto Maddaloni11Department of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeDepartment of Experimental Medicine, Sapienza University of RomeAbstract Background Cardiac autonomic neuropathy (CAN) is a life-threatening complication of diabetes. While obesity is a well-known risk factor of dysautonomia, the association between CAN and body fat distribution has not been fully clarified, especially in autoimmune diabetes (AD). Aim To evaluate if the association between CAN and body fat distribution differs between AD and type 2 diabetes (T2D). Methods Body fat distribution was evaluated by Dual X-Ray Absorptiometry in 143 people with diabetes (44 with ADand 99 with T2D) undergoing clinical screening for CAN. The association of CAN with markers of ectopic fat distribution was evaluated in multivariate regression models adjusting for confounders and testing for the interaction between diabetes type and CAN. Results A significant interaction between CAN and diabetes type was found with respect to markers of ectopic fat distribution. Specifically, people with CAN had significantly higher amount of visceral adipose tissue (530 [376–665]g versus 251[189–360]g, p = 0.001), total fat mass (22708[20200–27845]g versus 15434[12981–21879]g, p = 0,016), and trunk-to-leg ratio (0.88 [0.75–1.04] versus 0.70 [0.56–0.78], p = 0,023) compared to those without CAN only in participants with AD, but not in T2D (p-values for interaction < 0.05 for all comparisons). Conclusion Ectopic fat distribution is more strongly associated with CAN in AD than in T2D. This highlights the distinct role of fat distribution in the cardiometabolic health of people with AD, suggesting the need for further studies to better understand the pathophysiology and implications of overweight in this population.https://doi.org/10.1186/s12933-025-02635-6Autoimmune diabetesType 2 diabetesAdipose tissue distributionCardiac autonomic neuropathyObesity |
| spellingShingle | Renata Risi Rocco Amendolara Angelo Lauria Pantano Valeria Fassino Luca D’Onofrio Lucia Coraggio Daniela Luverà Davide Masi Mikiko Watanabe Lucio Gnessi Raffaella Buzzetti Ernesto Maddaloni Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes Cardiovascular Diabetology Autoimmune diabetes Type 2 diabetes Adipose tissue distribution Cardiac autonomic neuropathy Obesity |
| title | Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes |
| title_full | Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes |
| title_fullStr | Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes |
| title_full_unstemmed | Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes |
| title_short | Cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes |
| title_sort | cardiac autonomic neuropathy is associated with ectopic fat distribution in autoimmune but not in type 2 diabetes |
| topic | Autoimmune diabetes Type 2 diabetes Adipose tissue distribution Cardiac autonomic neuropathy Obesity |
| url | https://doi.org/10.1186/s12933-025-02635-6 |
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