The Significance of IDH1 Mutations in Tumor-Associated Seizure in 60 Chinese Patients with Low-Grade Gliomas
Background. Seizure is a common clinical presentation in patients suffering from primary brain tumors, especially from low-grade gliomas (LGGs). However, the genetic factors of tumor-associated seizure, at present, are still very poorly understood. The aim of this study was to investigate the potent...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | The Scientific World Journal |
| Online Access: | http://dx.doi.org/10.1155/2013/403942 |
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| author | Ruofei Liang Yingjun Fan Xiang Wang Qing Mao Yanhui Liu |
| author_facet | Ruofei Liang Yingjun Fan Xiang Wang Qing Mao Yanhui Liu |
| author_sort | Ruofei Liang |
| collection | DOAJ |
| description | Background. Seizure is a common clinical presentation in patients suffering from primary brain tumors, especially from low-grade gliomas (LGGs). However, the genetic factors of tumor-associated seizure, at present, are still very poorly understood. The aim of this study was to investigate the potential correlation between tumor-associated epilepsy and IDH1 mutations in a Chinese population with LGGs.
Materials and Methods. This study reviewed 60 patients with histologically confirmed low-grade gliomas, and the status of IDH1 was detected after the operation at our institution. Univariate and multivariate logistic regression analysis were used to explore the potential risk factors for tumor-related seizures. Results. IDH1 mutation was detected in 46 (76.7%) patients, among which 14 patients had no epilepsies and 32 patients had epilepsies (, chi-square test). Multivariate logistic regression analysis demonstrated that the mutation of IDH1 seems to be the strongest predictor for preoperative seizure (OR, 6.130; 95% CI, 1.523–24.669; ). Conclusions. IDH1 mutation was frequently detected in LGGs, and it may result in tumor-related seizures. |
| format | Article |
| id | doaj-art-d74a68ece8a242029332e1acec903bdb |
| institution | OA Journals |
| issn | 1537-744X |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | The Scientific World Journal |
| spelling | doaj-art-d74a68ece8a242029332e1acec903bdb2025-08-20T02:19:31ZengWileyThe Scientific World Journal1537-744X2013-01-01201310.1155/2013/403942403942The Significance of IDH1 Mutations in Tumor-Associated Seizure in 60 Chinese Patients with Low-Grade GliomasRuofei Liang0Yingjun Fan1Xiang Wang2Qing Mao3Yanhui Liu4Department of Neurosurgery, West China Hospital of Sichuan University, Chengdu 610041, ChinaDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu 610041, ChinaDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu 610041, ChinaDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu 610041, ChinaDepartment of Neurosurgery, West China Hospital of Sichuan University, Chengdu 610041, ChinaBackground. Seizure is a common clinical presentation in patients suffering from primary brain tumors, especially from low-grade gliomas (LGGs). However, the genetic factors of tumor-associated seizure, at present, are still very poorly understood. The aim of this study was to investigate the potential correlation between tumor-associated epilepsy and IDH1 mutations in a Chinese population with LGGs. Materials and Methods. This study reviewed 60 patients with histologically confirmed low-grade gliomas, and the status of IDH1 was detected after the operation at our institution. Univariate and multivariate logistic regression analysis were used to explore the potential risk factors for tumor-related seizures. Results. IDH1 mutation was detected in 46 (76.7%) patients, among which 14 patients had no epilepsies and 32 patients had epilepsies (, chi-square test). Multivariate logistic regression analysis demonstrated that the mutation of IDH1 seems to be the strongest predictor for preoperative seizure (OR, 6.130; 95% CI, 1.523–24.669; ). Conclusions. IDH1 mutation was frequently detected in LGGs, and it may result in tumor-related seizures.http://dx.doi.org/10.1155/2013/403942 |
| spellingShingle | Ruofei Liang Yingjun Fan Xiang Wang Qing Mao Yanhui Liu The Significance of IDH1 Mutations in Tumor-Associated Seizure in 60 Chinese Patients with Low-Grade Gliomas The Scientific World Journal |
| title | The Significance of IDH1 Mutations in Tumor-Associated Seizure in 60 Chinese Patients with Low-Grade Gliomas |
| title_full | The Significance of IDH1 Mutations in Tumor-Associated Seizure in 60 Chinese Patients with Low-Grade Gliomas |
| title_fullStr | The Significance of IDH1 Mutations in Tumor-Associated Seizure in 60 Chinese Patients with Low-Grade Gliomas |
| title_full_unstemmed | The Significance of IDH1 Mutations in Tumor-Associated Seizure in 60 Chinese Patients with Low-Grade Gliomas |
| title_short | The Significance of IDH1 Mutations in Tumor-Associated Seizure in 60 Chinese Patients with Low-Grade Gliomas |
| title_sort | significance of idh1 mutations in tumor associated seizure in 60 chinese patients with low grade gliomas |
| url | http://dx.doi.org/10.1155/2013/403942 |
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