Levels of Oxidized LDL, Estrogens, and Progesterone in Placenta Tissues and Serum Paraoxonase Activity in Preeclampsia
In vitro literature studies have suggested that atherosclerotic oxidized low density lipoprotein (OxLDL) inhibits trophoblast invasion. The objective of this study was to determine the levels of OxLDL and to examine the relationship between antioxidative estradiol, estriol, and prooxidative progesti...
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| Format: | Article |
| Language: | English |
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Wiley
2013-01-01
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| Series: | Mediators of Inflammation |
| Online Access: | http://dx.doi.org/10.1155/2013/862982 |
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| author | Şerefden Açıkgöz Ülkü Özmen Bayar Murat Can Berrak Güven Görkem Mungan Suat Doğan Vildan Sümbüloğlu |
| author_facet | Şerefden Açıkgöz Ülkü Özmen Bayar Murat Can Berrak Güven Görkem Mungan Suat Doğan Vildan Sümbüloğlu |
| author_sort | Şerefden Açıkgöz |
| collection | DOAJ |
| description | In vitro literature studies have suggested that atherosclerotic oxidized low density lipoprotein (OxLDL) inhibits trophoblast invasion. The objective of this study was to determine the levels of OxLDL and to examine the relationship between antioxidative estradiol, estriol, and prooxidative progestin in normal and preeclamptic placental tissues and measure the serum activity of antioxidative paraoxonase (PON1). The study included 30 preeclamptic and 32 normal pregnant women. OxLDL was determined with ELISA, estradiol, unconjugated estriol, and progesterone that were determined with chemiluminescence method in placental tissues. Serum PON1 activity was determined with spectrophotometric method. Levels of OxLDL (), estriol (), estradiol (), and progesterone () were lower in the placental tissues of preeclamptic group compared to the normal pregnant women. Serum PON1 activity was higher in preeclamptic group () and preeclamptic group without intrauterine growth restriction () compared to normal pregnant women. Tissue estriol of preeclamptic group without/with IUGR (, ) was lower than the normal group. Results of our study suggest that the events leading to fetoplacental insufficiency lead to a reduction in the levels of estriol limit deposition of OxLDL in placental tissues. The serum PON1 activity is probably important in the inhibition of OxLDL in preeclampsia. |
| format | Article |
| id | doaj-art-d74362e9219a40f1b819231cf7fc07d5 |
| institution | DOAJ |
| issn | 0962-9351 1466-1861 |
| language | English |
| publishDate | 2013-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Mediators of Inflammation |
| spelling | doaj-art-d74362e9219a40f1b819231cf7fc07d52025-08-20T03:23:55ZengWileyMediators of Inflammation0962-93511466-18612013-01-01201310.1155/2013/862982862982Levels of Oxidized LDL, Estrogens, and Progesterone in Placenta Tissues and Serum Paraoxonase Activity in PreeclampsiaŞerefden Açıkgöz0Ülkü Özmen Bayar1Murat Can2Berrak Güven3Görkem Mungan4Suat Doğan5Vildan Sümbüloğlu6Department of Biochemistry, Faculty of Medicine, Bülent Ecevit University, 67630 Zonguldak, TurkeyDepartment of Gynecology and Obstetrics, Faculty of Medicine, Bülent Ecevit University, 67630 Zonguldak, TurkeyDepartment of Biochemistry, Faculty of Medicine, Bülent Ecevit University, 67630 Zonguldak, TurkeyDepartment of Biochemistry, Faculty of Medicine, Bülent Ecevit University, 67630 Zonguldak, TurkeyDepartment of Biochemistry, Faculty of Medicine, Bülent Ecevit University, 67630 Zonguldak, TurkeyDepartment of Gynecology and Obstetrics, Faculty of Medicine, Bülent Ecevit University, 67630 Zonguldak, TurkeyDepartment of Biostatistics, Faculty of Medicine, Bülent Ecevit University, 67630 Zonguldak, TurkeyIn vitro literature studies have suggested that atherosclerotic oxidized low density lipoprotein (OxLDL) inhibits trophoblast invasion. The objective of this study was to determine the levels of OxLDL and to examine the relationship between antioxidative estradiol, estriol, and prooxidative progestin in normal and preeclamptic placental tissues and measure the serum activity of antioxidative paraoxonase (PON1). The study included 30 preeclamptic and 32 normal pregnant women. OxLDL was determined with ELISA, estradiol, unconjugated estriol, and progesterone that were determined with chemiluminescence method in placental tissues. Serum PON1 activity was determined with spectrophotometric method. Levels of OxLDL (), estriol (), estradiol (), and progesterone () were lower in the placental tissues of preeclamptic group compared to the normal pregnant women. Serum PON1 activity was higher in preeclamptic group () and preeclamptic group without intrauterine growth restriction () compared to normal pregnant women. Tissue estriol of preeclamptic group without/with IUGR (, ) was lower than the normal group. Results of our study suggest that the events leading to fetoplacental insufficiency lead to a reduction in the levels of estriol limit deposition of OxLDL in placental tissues. The serum PON1 activity is probably important in the inhibition of OxLDL in preeclampsia.http://dx.doi.org/10.1155/2013/862982 |
| spellingShingle | Şerefden Açıkgöz Ülkü Özmen Bayar Murat Can Berrak Güven Görkem Mungan Suat Doğan Vildan Sümbüloğlu Levels of Oxidized LDL, Estrogens, and Progesterone in Placenta Tissues and Serum Paraoxonase Activity in Preeclampsia Mediators of Inflammation |
| title | Levels of Oxidized LDL, Estrogens, and Progesterone in Placenta Tissues and Serum Paraoxonase Activity in Preeclampsia |
| title_full | Levels of Oxidized LDL, Estrogens, and Progesterone in Placenta Tissues and Serum Paraoxonase Activity in Preeclampsia |
| title_fullStr | Levels of Oxidized LDL, Estrogens, and Progesterone in Placenta Tissues and Serum Paraoxonase Activity in Preeclampsia |
| title_full_unstemmed | Levels of Oxidized LDL, Estrogens, and Progesterone in Placenta Tissues and Serum Paraoxonase Activity in Preeclampsia |
| title_short | Levels of Oxidized LDL, Estrogens, and Progesterone in Placenta Tissues and Serum Paraoxonase Activity in Preeclampsia |
| title_sort | levels of oxidized ldl estrogens and progesterone in placenta tissues and serum paraoxonase activity in preeclampsia |
| url | http://dx.doi.org/10.1155/2013/862982 |
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